This collection showcases the journal articles and other publications authored by researchers in the Stephen Jones Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2014

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Fidelity of Histone Gene Regulation is Obligatory for Genome Replication and Stability, Prachi N. Ghule, Ronglin Xie, Ricardo F. Medina, Jennifer L. Colby, Stephen N. Jones, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, and Gary S. Stein (Molecular and cellular biology)

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Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner, Rachel Miloslavski, Elad Cohen, Adam Avraham, Yifat Iluz, Zvi Hayouka, Judith Kasir, Rajini R. Mudhasani, Stephen N. Jones, Nadine Cybulski, Markus A. Ruegg, Ola Larsson, Valentina Gandin, Arjuna Rajakumar, Ivan Topisirovic, and Oded Meyuhas (Journal of molecular cell biology)

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RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach (Nature)

Submissions from 2013

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Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1, Charusheila Ramkumar, Hang Cui, Yahui Kong, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang (Nature communications)

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MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma, Margaretha Van der Deen, Hanna Taipaleenmaki, Ying Zhang, Nadiya M. Teplyuk, Anurag Gupta, Senthilkumar Cinghu, Kristen Shogren, Avudaiappan Maran, Michael J. Yaszemski, Ling Ling, Simon M. Cool, David Tai Leong, Christian Dierkes, Jozef Zustin, Manuel Salto-Tellez, Yoshiaki Ito, Suk-Chul Bae, Maria Zielenska, Jeremy A. Squire, Jane B. Lian, Janet L. Stein, Gerard P. Zambetti, Stephen N. Jones, Mario Galindo, Eric Hesse, Gary S. Stein, and Andre J. van Wijnen (The Journal of biological chemistry)

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DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway, Guohui Wan, Xinna Zhang, Robert R. Langley, Yunhua Liu, Xiaoxiao Hu, Cecil Han, Guang Peng, Lee M. Ellis, Stephen N. Jones, and Xiongbin Lu (Cell reports)

Submissions from 2012

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Human Genome-Wide Association and Mouse Knockout Approaches Identify Platelet Supervillin as an Inhibitor of Thrombus Formation under Shear Stress, Leonard C. Edelstein, Elizabeth J. Luna, Ian B. Gibson, Molly Bray, Ying Jin, Altaf Kondkar, Srikanth Nagalla, Nacima Hadjout-Rabi, Tara C. Smith, Daniel Covarrubias, Stephen N. Jones, Firdos Ahmad, Moritz Stolla, Xianguo Kong, Zhiyou Fang, Wolfgang Bergmeier, Chad Shaw, Suzanne M. Leal, and Paul F. Bray (Circulation)

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Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis, Hugh S. Gannon and Stephen N. Jones (Genes and cancer)

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ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice, Hugh S. Gannon, Bruce A. Woda, and Stephen N. Jones (Cancer cell)

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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang (Cancer research)

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Conditional Aurora A deficiency differentially affects early mouse embryo patterning, Yeonsoo Yoon, Dale O. Cowley, Judith Gallant, Stephen N. Jones, Terry Van Dyke, and Jaime A. Rivera-Perez (Developmental biology)

Submissions from 2011

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Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons, Michael J. Bianchetta, TuKiet T. Lam, Stephen N. Jones, and Maria A. Morabito (The Journal of neuroscience : the official journal of the Society for Neuroscience)

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Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin, Hugh S. Gannon, Lawrence A. Donehower, Stephen Lyle, and Stephen N. Jones (Developmental biology)

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Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation, Julie C. Liu, Christopher Joachim Lengner, Tripti Gaur, Yang Lou, Sadiq Hussain, Marci D. Jones, Brent Borodic, Jennifer L. Colby, Heather Anne Steinman, Andre J. Van Wijnen, Janet L. Stein, Stephen N. Jones, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development, Lijun Liu, Ronglin Xie, Sadiq Hussain, Jane B. Lian, Jaime A. Rivera-Perez, Stephen N. Jones, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Gene)

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Dicer is required for the formation of white but not brown adipose tissue, Rajini R. Mudhasani, Vishwajeet Puri, Kathleen Hoover, Michael P. Czech, Anthony N. Imbalzano, and Stephen N. Jones (Journal of cellular physiology)

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Mice defective in p53 nuclear localization signal 1 exhibit exencephaly, Anouk Regeling, Heather L. Armata, Judith Gallant, Stephen N. Jones, and Hayla Karen Sluss (Transgenic research)

Submissions from 2010

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MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival, Maria Pia Arrate, Tiffaney Vincent, Jessica Odvody, Rekha Kar, Stephen N. Jones, and Christine M. Eischen (Cancer research)

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Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity, Andrew H. Coles, Hugh S. Gannon, Anna M. Cerny, Evelyn A. Kurt-Jones, and Stephen N. Jones (Proceedings of the National Academy of Sciences of the United States of America)

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Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation, Christopher R. Dowdy, Ronglin Xie, Dana Frederick, Sadiq Hussain, Sayyed K. Zaidi, Diana Vradii, Amjad Javed, Xiangen Li, Stephen N. Jones, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Human molecular genetics)

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Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse, Tripti Gaur, Sadiq Hussain, Rajini R. Mudhasani, Isha Parulkar, Jennifer L. Colby, Dana Frederick, Barbara E. Kream, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Stephen N. Jones, and Jane B. Lian (Developmental biology)

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Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function, Chandrashekara Mallappa, Brian T. Nasipak, Letitiah Etheridge, Elliot J. Androphy, Stephen N. Jones, Charles G. Sagerstrom, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Molecular and cellular biology)

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Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl, Emily F. Mason, Yuxing Zhao, Pankuri Goraksha-Hicks, Jonathan L. Coloff, Hugh S. Gannon, Stephen N. Jones, and Jeffrey C. Rathmell (Cancer research)

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An essential role for Dicer in adipocyte differentiation, Rajini R. Mudhasani, Anthony N. Imbalzano, and Stephen N. Jones (Journal of cellular biochemistry)

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Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice, JongDae Shin, Michael Bossenz, Young Chung, Hong Ma, Meg Byron, Naoko Taniguchi-Ishigaki, Xiaochun Zhu, Jiao Baowei, Lisa L. Hall, Michael R. Green, Stephen N. Jones, Irm Hermans-Borgmeyer, Jeanne B. Lawrence, and Ingolf Bach (Nature)

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Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis, Hayla Karen Sluss, Hugh S. Gannon, Andrew H. Coles, Qichang Shen, Christine M. Eischen, and Stephen N. Jones (Molecular cancer research : MCR)

Submissions from 2009

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The ING gene family in the regulation of cell growth and tumorigenesis, Andrew H. Coles and Stephen N. Jones (Journal of cellular physiology)

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Embryonic stem cell rescue of tremor and ataxia in myelin-deficient shiverer mice, Hoi Pang Low, Beatrice Greco, Yusuke Tanahashi, Judith Gallant, Stephen N. Jones, Susan Billings-Gagliardi, Lawrence D. Recht, and William J. Schwartz (Journal of the neurological sciences)

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The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles, Ronglin Xie, Ricardo F. Medina, Ying Zhang, Sadiq Hussain, Jennifer Colby, Prachi N. Ghule, Sakthi Sundararajan, Marilyn L. Keeler, Lijun Liu, Margaretha Van der Deen, Partha Mitra, Jane B. Lian, Jaime A. Rivera-PĂ©rez, Stephen N. Jones, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response, Xinna Zhang, Lin Lin, Huarong Guo, Jianhua Yang, Stephen N. Jones, Aart Jochemsen, and Xiongbin Lu (Cancer research)

Submissions from 2008

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ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage, Lufen Chang, Bingsen Zhou, Shuya Hu, Robin Guo, Xiyong Liu, Stephen N. Jones, and Yun Yen (Proceedings of the National Academy of Sciences of the United States of America)

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p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis, Andrew H. Coles, Concetta G. A. Marfella, Anthony N. Imbalzano, Heather Anne Steinman, David S. Garlick, Rachel M. Gerstein, and Stephen N. Jones (Cancer research)

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The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis, Agnes Delaunay, Kenneth D. Bromberg, Yukiko Hayashi, Massimiliano Mirabella, Denise Burch, Brian Kirkwood, Carlo Serra, May C. Malicdan, Andrew P. Mizisin, Roberta Morosetti, Aldobrando Broccolini, Ling T. Guo, Stephen N. Jones, Sergio A. Lira, Pier Lorenzo Puri, G. Diane Shelton, and Ze'ev Ronai (PloS one)

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Mammalian SNM1 is required for genome stability, A. W. Hemphill, D. Bruun, L. Thrun, Y. Akkari, Y. Torimaru, K. Hejna, P. M. Jakobs, J. Hejna, Stephen N. Jones, S. B. Olson, and R. E. Moses (Molecular genetics and metabolism)

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A Runx2 threshold for the cleidocranial dysplasia phenotype, Yang Lou, Amjad Javed, Sadiq Hussain, Jennifer Colby, Dana Frederick, Jitesh Pratap, Ronglin Xie, Tripti Gaur, Andre J. Van Wijnen, Stephen N. Jones, Gary S. Stein, Jane B. Lian, and Janet L. Stein (Human molecular genetics)

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MdmX regulates transformation and chromosomal stability in p53-deficient cells, Zdenka Matijasevic, Anna Krzywicka-Racka, Greenfield Sluder, and Stephen N. Jones (Cell cycle (Georgetown, Tex.))

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Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells, Rajini R. Mudhasani, Zhiqing Zhu, Gyorgy Hutvagner, Christine M. Eischen, Stephen Lyle, Lisa L. Hall, Jeanne B. Lawrence, Anthony N. Imbalzano, and Stephen N. Jones (The Journal of cell biology)

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Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells, P. Wang, T. Lushnikova, Jessica Odvody, T. C. Greiner, Stephen N. Jones, and Christine M. Eischen (Oncogene)

Submissions from 2007

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Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis, Andrew H. Coles, Huiling Liang, Zhiqing Zhu, Concetta G. A. Marfella, Joonsoo Kang, Anthony N. Imbalzano, and Stephen N. Jones (Cancer research)

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Noncanonical Wnt signaling promotes apoptosis in thymocyte development, Huiling Liang, Andrew H. Coles, Zhiqing Zhu, Jennifer Zayas, Roland Jurecic, Joonsoo Kang, and Stephen N. Jones (The Journal of experimental medicine)

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop, Xiongbin Lu, Ou Ma, Thuy-Ai Nguyen, Stephen N. Jones, Moshe Oren, and Lawrence A. Donehower (Cancer cell)

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MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice, Zdenka Matijasevic, Heather Anne Steinman, Kathleen Hoover, and Stephen N. Jones (Molecular and cellular biology)

Submissions from 2006

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Nuclease sensitive element binding protein 1 gene disruption results in early embryonic lethality, Lin Fan, Stephen N. Jones, Carolyn Padden, Qichang Shen, and Peter E. Newburger (Journal of cellular biochemistry)

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Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor, Kristopher K. Frese, Isabel J. Latorre, Sang-Hyuk Chung, Georgina Caruana, Alan Bernstein, Stephen N. Jones, Lawrence A. Donehower, Monica J. Justice, Craig C. Garner, and Ronald T. Javier (The EMBO journal)

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Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis, Cynthia J. Guidi, Rajini R. Mudhasani, Kathleen Hoover, Andrew Koff, Irwin Leav, Anthony N. Imbalzano, and Stephen N. Jones (Cancer research)

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Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling, Christopher J. Lengner, Heather Anne Steinman, James Gagnon, Thomas W. Smith, Janet E. Henderson, Barbara E. Kream, Gary S. Stein, Jane B. Lian, and Stephen N. Jones (The Journal of cell biology)

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Mutation of the SNF2 family member Chd2 affects mouse development and survival, Concetta G. A. Marfella, Ohkawa Yasuyuki, Andrew H. Coles, David S. Garlick, Stephen N. Jones, and Anthony N. Imbalzano (Journal of cellular physiology)

Submissions from 2005

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Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development, Damon R. Asher, Anna M. Cerny, Sarah R. Weiler, James W. Horner, Marilyn L. Keeler, Mychell A. Neptune, Stephen N. Jones, Roderick T. Bronson, Ronald A. DePinho, and Robert W. Finberg (Genesis (New York, N.Y. : 2000))

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Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability, Anthony N. Imbalzano and Stephen N. Jones (Cancer cell)

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A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1), Alexander Repik, Steve E. Pincus, Ionita Ghiran, Anne Nicholson-Weller, Damon R. Asher, Anna M. Cerny, Leslie S. Casey, S. M. Jones, Stephen N. Jones, Nehal Mohamed, Lloyd B. Klickstein, George L. Spitalny, and Robert W. Finberg (Clinical and experimental immunology)

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Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development, Heather Anne Steinman, Kathleen Hoover, Marilyn L. Keeler, Arthur T. Sands, and Stephen N. Jones (Oncogene)

Submissions from 2004

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WNT5A signaling affects pituitary gland shape, Kelly B. Cha, Kristin R. Douglas, Mary Anne Potok, Huiling Liang, Stephen N. Jones, and Sally A. Camper (Mechanisms of development)

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Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes, Diem N. Doan, Timothy M. Veal, Zhijiang Yan, Weidong Wang, Stephen N. Jones, and Anthony N. Imbalzano (Oncogene)

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Differentiation prevents assessment of neural stem cell pluripotency after blastocyst injection, Beatrice Greco, Hoi Pang Low, Eric C. Johnson, Rebecca Salmonsen, Judith Gallant, Stephen N. Jones, Alonzo H. Ross, and Lawrence D. Recht (Stem cells (Dayton, Ohio))

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Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor, Cynthia J. Guidi, Timothy M. Veal, Stephen N. Jones, and Anthony N. Imbalzano (The Journal of biological chemistry)

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Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs, Huiling Liang, Helen Atkins, Rana Abdel-Fattah, Stephen N. Jones, and John Lunec (Gene)

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Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2, Harry A. Rogoff, Mary T. Pickering, Fiona M. Frame, Michelle E. Debatis, Yolanda Sanchez, Stephen N. Jones, and Timothy F. Kowalik (Molecular and cellular biology)

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Phosphorylation of serine 18 regulates distinct p53 functions in mice, Hayla Karen Sluss, Heather L. Armata, Judith Gallant, and Stephen N. Jones (Molecular and cellular biology)

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Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth, Heather Anne Steinman, Hayla Karen Sluss, Arthur T. Sands, German A. Pihan, and Stephen N. Jones (Oncogene)

Submissions from 2003

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Suppression of Ras-stimulated transformation by the JNK signal transduction pathway, Norman J. Kennedy, Hayla Karen Sluss, Stephen N. Jones, Dafna Bar-Sagi, Richard A. Flavell, and Roger J. Davis (Genes and development)

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Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue, Huiling Liang, Qin Chen, Andrew H. Coles, Stephen J. Anderson, German A. Pihan, Allan Bradley, Rachel M. Gerstein, Roland Jurecic, and Stephen N. Jones (Cancer cell)

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Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis, Lynette Moore, Sundaresan Venkatachalam, Hannes Vogel, Julie C. Watt, Chao-Ling Wu, Heather Anne Steinman, Stephen N. Jones, and Lawrence A. Donehower (Oncogene)

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An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis, Heather Anne Steinman, Ezra Burstein, Christopher J. Lengner, Joseph R. Gosselin, German A. Pihan, Colin S. Duckett, and Stephen N. Jones (The Journal of biological chemistry)

Submissions from 2002

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Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility, Mai X. Luong, Caroline M. J. van der Meijden, DongXia Xing, RuthAnn M. Hesselton, Edwin S. Monuki, Stephen N. Jones, Jane B. Lian, Janet L. Stein, Gary S. Stein, Ellis J. Neufeld, and Andre J. Van Wijnen (Molecular and cellular biology)

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E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis, Harry A. Rogoff, Mary Theresa Pickering, Michelle E. Debatis, Stephen N. Jones, and Timothy F. Kowalik (Molecular and cellular biology)

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Nitric oxide-mediated inhibition of Hdm2-p53 binding, Christopher M. Schonhoff, Marie-Claire Daou, Stephen N. Jones, Celia A. Schiffer, and Alonzo H. Ross (Biochemistry)

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Generation of an Mdm2 conditional allele in mice, Heather Anne Steinman and Stephen N. Jones (Genesis (New York, N.Y. : 2000))

Submissions from 2001

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Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development, Je-Yong Choi, Jitesh Pratap, Amjad Javed, Sayyed K. Zaidi, Lianping Xing, Eva Balint, Sara Dalamangas, Brendan F. Boyce, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, Stephen N. Jones, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Cynthia J. Guidi, Arthur T. Sands, Brian P. Zambrowicz, Tod K. Turner, Delia A. Demers, William Webster, Thomas W. Smith, Anthony N. Imbalzano, and Stephen N. Jones (Molecular and cellular biology)

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MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines, Cathy Tournier, Chen Dong, Tod K. Turner, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis (Genes and development)

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Requirement of the JIP1 scaffold protein for stress-induced JNK activation, Alan J. Whitmarsh, Chia-Yi Kuan, Norman J. Kennedy, Nyaya Kelkar, Tarik F. Haydar, John P. Mordes, Michael C. Appel, Aldo A. Rossini, Stephen N. Jones, Richard A. Flavell, Pasko Rakic, and Roger J. Davis (Genes and development)

Submissions from 2000

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Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene, Hicham Drissi, Quyen Luc, A. Rauf Shakoori, Susana Chuva De Sousa Lopes, Je-Yong Choi, Anne Terry, Ming Hu, Stephen N. Jones, James C. Neil, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway, Cathy Tournier, Patricia M. Hess, Derek D. Yang, Jie Xu, Tod K. Turner, Anjaruwee S. Nimnual, Dafna Bar-Sagi, Stephen N. Jones, Richard A. Flavell, and Roger J. Davis (Science (New York, N.Y.))

Submissions from 1998

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis, Stephen N. Jones, Amy R. Hancock, Hannes Vogel, Lawrence A. Donehower, and Allan Bradley (Proceedings of the National Academy of Sciences of the United States of America)