Title
Metabolic characterization of nondiabetic severely obese patients undergoing Roux-en-Y gastric bypass: preoperative classification predicts the effects of gastric bypass on insulin-glucose homeostasis
UMMS Affiliation
Information Services, Academic Computing Services; Department of Cell Biology; Department of Surgery
Date
6-26-2007
Document Type
Article
Subjects
Adipose Tissue; Adult; B-Lymphocytes; Body Mass Index; Chemiluminescent Measurements; Female; Gastric Bypass; Glucose; Homeostasis; Humans; Immunoassay; Insulin; Insulin Resistance; Male; Middle Aged; Obesity, Morbid
Disciplines
Gastroenterology | Surgery
Abstract
INTRODUCTION: Obese individuals may have normal insulin-glucose homeostasis, insulin resistance, or diabetes mellitus. Whereas gastric bypass cures insulin resistance and diabetes mellitus, its effects on normal physiology have not been described. We studied insulin resistance and beta-cell function for patients undergoing gastric bypass.
METHODS: One hundred thirty-eight patients undergoing gastric bypass had fasting insulin and glucose levels drawn on days 0, 12, 40, 180, and 365. Thirty-one (22%) patients with diabetes mellitus were excluded from this analysis. Homeostatic model of assessment was used to estimate insulin resistance, insulin sensitivity, and beta-cell function. Based on this model, patients were categorized as high insulin resistance if their insulin resistance was >2.3.
RESULTS: Body mass index did not correlate with insulin resistance. Forty-seven (34%) patients were categorized as high insulin resistance. Correction of insulin resistance for this group occurred by 12 days postoperatively. Sixty (43%) patients were categorized as low insulin resistance. They demonstrated an increase of beta-cell function by 12 days postoperatively, which returned to baseline by 6 months. At 1 year postoperatively, the low insulin resistance group had significantly higher beta-cell function per degree of insulin sensitivity.
CONCLUSIONS: Adipose mass alone cannot explain insulin resistance. Severely obese individuals can be categorized by degree of insulin resistance, and the effect of gastric bypass depends upon this preoperative physiology.
Rights and Permissions
Citation: J Gastrointest Surg. 2007 Sep;11(9):1083-90. Link to article on publisher's site
Related Resources
PubMed ID
17588192