Title
Tamoxifen decreases lipoprotein (a) in patients with breast cancer
UMMS Affiliation
Information Services, Academic Computing Services; Department of Cell Biology; Diabetes and Endocrinology Research Center
Date
5-1-1994
Document Type
Article
Subjects
Breast Neoplasms; Female; Humans; Lipids; Lipoprotein(a); Middle Aged; Tamoxifen; Time Factors
Disciplines
Cancer Biology | Endocrine System Diseases
Abstract
An elevated concentration of lipoprotein(a) [Lp(a)] is a potent risk factor for coronary atherosclerosis. Recently, several hormonal agents including estrogen have been reported to decrease serum Lp(a) concentrations. We found that the antiestrogen tamoxifen also decreased Lp(a) concentrations approximately 40% in six patients with breast cancer, an effect that was achieved by 1 month of therapy and that was stable in five of six patients. If the Lp(a)-lowering effect of tamoxifen can be replicated in women without breast cancer, tamoxifen might be considered as an alternative to niacin for the treatment of elevated Lp(a) levels.
Rights and Permissions
Citation: Metabolism. 1994 May;43(5):531-2.
Related Resources
PubMed ID
8177039