Tamoxifen decreases lipoprotein (a) in patients with breast cancer
Information Services, Academic Computing Services; Department of Cell Biology; Diabetes and Endocrinology Research Center
Breast Neoplasms; Female; Humans; Lipids; Lipoprotein(a); Middle Aged; Tamoxifen; Time Factors
Cancer Biology | Endocrine System Diseases
An elevated concentration of lipoprotein(a) [Lp(a)] is a potent risk factor for coronary atherosclerosis. Recently, several hormonal agents including estrogen have been reported to decrease serum Lp(a) concentrations. We found that the antiestrogen tamoxifen also decreased Lp(a) concentrations approximately 40% in six patients with breast cancer, an effect that was achieved by 1 month of therapy and that was stable in five of six patients. If the Lp(a)-lowering effect of tamoxifen can be replicated in women without breast cancer, tamoxifen might be considered as an alternative to niacin for the treatment of elevated Lp(a) levels.
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Citation: Metabolism. 1994 May;43(5):531-2.