Title

Tamoxifen and estrogen lower circulating lipoprotein(a) concentrations in healthy postmenopausal women

UMMS Affiliation

Information Services, Academic Computing Services; Department of Cell Biology; Diabetes and Endocrinology Research Center

Date

10-1-1994

Document Type

Article

Subjects

Aged; Carrier Proteins; Cholesterol, LDL; Double-Blind Method; Estrogens; Female; Humans; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Lipoprotein(a); Middle Aged; Osmolar Concentration; Postmenopause; Reference Values; Somatomedins; Tamoxifen

Disciplines

Oncology | Pharmacy and Pharmaceutical Sciences

Abstract

Data in the literature suggest that circulating levels of lipoprotein(a) [Lp(a)] and insulinlike growth factor I (IGF-I) respond similarly to therapy with growth hormone, estrogen, or tamoxifen. To more clearly document these relations, we designed a randomized, double-blind, placebo-controlled study of the effects of tamoxifen and continuous estrogen on circulating levels of Lp(a), IGF-I, and IGF binding protein 3 (IGFBP-3) in healthy postmenopausal women. Both estrogen and tamoxifen decreased serum levels of IGF-I to 30% below baseline during the 3 months of treatment, while IGFBP-3 levels were unchanged. Plasma Lp(a) levels decreased to 24% below baseline after 1 month of treatment with either estrogen or tamoxifen (P < .05 for estrogen only); after 3 months Lp(a) decreased to 34% below baseline with tamoxifen therapy (P < .05) but returned to only 16% below baseline with estrogen. The correlation between Lp(a) and IGF-I was highly significant (P < .0001). We conclude that (1) tamoxifen lowers plasma Lp(a) levels in healthy postmenopausal women, (2) the suppressive effects of tamoxifen and estrogen on circulating Lp(a) concentration diverge after the first month of therapy, and (3) circulating levels of Lp(a) and IGF-I are strongly correlated with each other, an indication that they may share regulatory influences.

Rights and Permissions

Citation: Arterioscler Thromb. 1994 Oct;14(10):1586-93.

Related Resources

Link to article in PubMed

PubMed ID

7522547