This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2014

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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection, Marco A. Ataide, Warrison A. Andrade, Dario S. Zamboni, Wang Donghai, Maria do Carmo Souza, Bernardo S. Franklin, Samir Elian, Flaviano S. Martins, Dhelio Pereira, George W. Reed, Katherine A. Fitzgerald, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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Long non-coding RNAs and control of gene expression in the immune system, Maninjay K. Atianand and Katherine A. Fitzgerald

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Recognition of cytosolic DNA by cGAS and other STING-dependent sensors, Numana Bhat and Katherine A. Fitzgerald

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Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond, Susan Carpenter and Katherine A. Fitzgerald

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Post-transcriptional regulation of gene expression in innate immunity, Susan Carpenter, Emiliano P. Ricci, Blandine C. Mercier, Melissa J. Moore, and Katherine A. Fitzgerald

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Citrobacter rodentium: infection, inflammation and the microbiota, James W Collins, Kristie M. Keeney, Valerie F. Crepin, Vijay A. K. Rathinam, Katherine A. Fitzgerald, B. Brett Finlay, and Gad Frankel

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Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis, Timea Csak, Arun Pillai, Michal Ganz, Dora Lippai, Jan Petrasek, Jin-Kyu Park, Karen Kodys, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1beta interferes with mature IL-1beta signaling, Facundo Davaro, Sorcha D. Forde, Mark Garfield, Zhaozhao Jiang, Kristen A. Halmen, Nelsy DePaula Tamburro, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Douglas T. Golenbock, and Wang Donghai

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Genetic rescue of functional senescence in synaptic and behavioral plasticity, Jeffrey M. Donlea, Narendrakumar Ramanan, Neal S. Silverman, and Paul J. Shaw

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TLR4 activation induces IL-1ss release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung, Suffwan Eltom, Maria G. Belvisi, Liang Yew-Booth, Bilel Dekkak, Sarah A. Maher, Eric D. Dubuis, Victoria Jones, Kate A. Fitzgerald, and Mark A. Birrell

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Long noncoding RNAs in innate and adaptive immunity, Katherine A. Fitzgerald and Daniel R. Caffrey

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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello

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Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans, Sandhya Ganesan, Vijay A. K. Rathinam, Lukas Bossaller, Kelly Army, William J. Kaiser, Edward S. Mocarski, Christopher P. Dillon, Douglas R. Green, Tanya N. Mayadas, Stuart M. Levitz, Amy G. Hise, Neal S. Silverman, and Katherine A. Fitzgerald

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Innate sensing of malaria parasites, Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald, and Douglas T. Golenbock

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RNA and beta-hemolysin of Group B streptococcus induce IL-1beta by activating NLRP3 inflammasomes in mouse macrophages, Rahul Gupta, Shubhendu Ghosh, Brian G. Monks, Rosane B. DeOliveira, TeChen Tzeng, Parisa Kalantari, Anubhab Nandy, Bornali Bhattacharjee, Jennie Chan, Fabianno Ferreira, Vijay A.K. Rathinam, Shrutie Sharma, Egil Lien, Neal S. Silverman, Katherine A. Fitzgerald, Arnaud Firon, Patrick Trieu-Cuot, Philipp Henneke, and Douglas T. Golenbock

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SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter, Claudia Gurtler, Michael Carty, Jay Kearney, Stefan A. Schattgen, Aihao Ding, Katherine A. Fitzgerald, and Andrew G. Bowie

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TRIF signaling is essential for TLR4-driven IgE class switching, Erin Janssen, Esra Ozcan, Kyriaki Liadaki, Haifa H. Jabara, John Manis, Sumana Ullas, Shizuo Akira, Katherine A. Fitzgerald, Douglas T. Golenbock, and Raif S. Geha

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Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria, Parisa Kalantari, Rosane B. de Oliveira, Jennie Chan, Yolanda Corbett, Vijay A. K. Rathinam, Andrea Stutz, Eicke Latz, Ricardo T. Gazzinelli, Douglas T. Golenbock, and Katherine A. Fitzgerald

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The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35, Chan-Hee Kim, Donggi Paik, Florentina Rus, and Neal S. Silverman

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The Drosophila IMD pathway in the activation of the humoral immune response, Anni Kleino and Neal S. Silverman

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes, Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan, Qian Yin, Maninjay K. Atianand, Matthijn R. Vos, Gunnar F. Schroder, Katherine A. Fitzgerald, Hao Wu, and Edward H. Egelman

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IKKalpha negatively regulates ASC-dependent inflammasome activation, Bradley N. Martin, Chenhui Wang, Jami Willette-Brown, Tomasz Herjan, Muhammet F Gulen, Hao Zhou, Katarzyna Bulek, Luigi Franchi, Takashi Sato, Emad S. Alnemri, Goutham Narla, Xiao -Ping Zhong, James Thomas, Dennis Klinman, Katherine A. Fitzgerald, Michael Karin, Gabriel Nunez, George Dubyak, Yinling Hu, and Xiaoxia Li

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The hunt for protective correlates of immunity to Plasmodium falciparum malaria, Ann M. Moormann and V. Ann Stewart

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Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals, Ryan H. Moy, Beth Gold, Jerome M. Molleston, Veronica Schad, Kilangsungla Yanger, Mary-Virginia Salzano, Yoshimasa Yagi, Katherine A. Fitzgerald, Ben Z. Stanger, Samantha S. Soldan, and Sara Cherry

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TRIM13 is a negative regulator of MDA5-mediated type I interferon production, Kavitha Narayan, Lisa Waggoner, Serena T Pham, Gabriel L. Hendricks, Stephen N. Waggoner, Joseph E. Conlon, Jennifer Wang, Katherine A. Fitzgerald, and Joonso Kang

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Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation, Christian Schmidt-Lauber, Lukas Bossaller, Hani H. Abujudeh, Gregory I. Vladimer, Anette Christ, Katherine A. Fitzgerald, Eicke Latz, Ellen M. Gravallese, Ann Marshak-Rothstein, and Jonathan Kay

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The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8, Martina Severa, Sabina A. Islam, Stephen N. Waggoner, Zhaozhao Jiang, Nancy D. Kim, Glennice Bowen Ryan, Evelyn A. Kurt-Jones, Israel Charo, Daniel R. Caffrey, Victor L. Boyartchuk, Andrew D. Luster, and Katherine A. Fitzgerald

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Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever, Babs R. Soller, Anon Srikiatkhachorn, Fengmei Zou, Alan L. Rothman, In-Kyu Yoon, Robert V. Gibbons, Siripen Kalayanarooj, Stephen J. Thomas, and Sharone Green

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Interferon gamma-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses, Mikayla R. Thompson, Shrutie Sharma, Maninjay K. Atianand, Soren B. Jensen, Susan Carpenter, David M. Knipe, Katherine A. Fitzgerald, and Evelyn A. Kurt-Jones

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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome, Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian M. Skehan, Katherine A. Fitzgerald, and John M. Leong

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

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TRIL is involved in cytokine production in the brain following Escherichia coli infection, Paulina Wochal, Vijay A. K. Rathinam, Aisling Dunne, Thaddeus Carlson, Wen Kuang, Katherine J. Seidl, J. Perry Hall, Lih-Ling Lin, Mary Collins, Stefan A. Schattgen, Christopher R. MacKay, Caio T. Fagundes, Susan Carpenter, Katherine A. Fitzgerald, and Luke A.J. O'Neill

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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING, Lu Zhang, Jinyao Mo, Karen V. Swanson, Haitao Wen, Alex Petrucelli, Sean M. Gregory, Zhigang Zhang, Monika Schneider, Yan Jiang, Katherine A. Fitzgerald, Songying Ouyang, Zhi-Jie Liu, Blossom Damania, Hong-Bing Shu, Joseph A. Duncan, and Jenny P-Y Ting

Publications from 2013

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Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice, Warrison A. Andrade, Maria do Carmo Souza, Espiridion Ramos-Martinez, Kamalpreet Nagpal, Miriam S. Dutra, Mariane B. Melo, Daniella C. Bartholomeu, Sankar Ghosh, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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Molecular basis of DNA recognition in the immune system, Maninjay K. Atianand and Katherine A. Fitzgerald

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SnapShot: inflammasomes, Maninjay K. Atianand, Vijay A. K. Rathinam, and Katherine A. Fitzgerald

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Monoclonal antibody treatments for rheumatoid arthritis, Lukas Bossaller and Achim Rothe

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Innate sensing of chitin and chitosan, Chelsea L. Bueter, Charles A. Specht, and Stuart M. Levitz

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Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy, Rachel Buglione-Corbett, Kimberly Lea Pouliot, Robyn Lynn Marty-Roix, Kim West, Shixia Wang, Egil Lien, and Shan Lu

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A long noncoding RNA mediates both activation and repression of immune response genes, Susan Carpenter, Daniel Aiello, Maninjay K. Atianand, Emiliano P. Ricci, Pallavi Gandhi, Lisa L. Hall, Meg Byron, Brian G. Monks, Meabh Henry-Bezy, Jeanne B. Lawrence, Luke A. J. O'Neill, Melissa J. Moore, Daniel R. Caffrey, and Katherine A. Fitzgerald

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A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design, Yuxin Chen, Michael Vaine, Aaron Wallace, Dong Han, Shengqin Wan, Michael S. Seaman, David C. Montefiori, Shixia Wang, and Shan Lu

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Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid, Joseph E. Conlon, Dara Burdette, Shrutie Sharma, Numana Bhat, Mikayla R. Thompson, Zhaozhao Jiang, Vijay A. K. Rathinam, Brian G. Monks, Tengchuan Jin, T. Sam Xiao, Stefanie N. Vogel, Russell E. Vance, and Katherine A. Fitzgerald

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Rift Valley fever virus infection induces activation of the NLRP3 inflammasome, Megan E. Ermler, Zachary Traylor, Krupen Patel, Stefan A. Schattgen, Sivapriya K. Vanaja, Katherine A. Fitzgerald, and Amy G. Hise

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Human papillomavirus E7 induces rereplication in response to DNA damage, Xueli Fan, Yingwang Liu, Susan Ann Heilman, and Jason J. Chen

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East North Central region has the highest prevalence of vancomycin-resistant Enterococcus faecalis in the United States, Sumanth Gandra, Nikolay Braykov, and Ramanan Laxminarayan

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C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness, John Patrick Haran, Francesca Lynn Beaudoin, Selim Suner, and Shan Lu

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Cytokine markers as predictors of type of respiratory infection in patients during the influenza season, John Patrick Haran, Rachel Buglione-Corbett, and Shan Lu

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Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus, Gabriel L. Hendricks, Kim L. Weirich, Karthik Viswanathan, Jing Li, Zachary H. Shriver, Joseph Ashour, Hidde L. Ploegh, Evelyn A. Kurt-Jones, Deborah K. Fygenson, Robert W. Finberg, James C. Comolli, and Jennifer P. Wang

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Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity, Hye Young Kim, Hyun Jun Lee, Ya-Jen Chang, Muriel Pichavant, Stephanie A. Shore, Katherine A. Fitzgerald, Yoichiro Iwakura, Elliot Israel, Kenneth Bolger, John Faul, Rosemarie H. DeKruyff, and Dale T. Umetsu

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Factor H-Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis, Lisa A. Lewis, David M. Vu, Shreekant Vasudhev, Jutamas Shaughnessy, Dan M. Granoff, and Sanjay Ram

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Breastfeeding During Early Infancy is Associated with a Lower Incidence of Febrile Illnesses, Daniel H. Libraty, Rosario Z. Capeding, Anamae Obcena, Job D. Brion, and Veronica Tallo

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Breastfeeding During Early Infancy is Associated with Higher Weight-Based World Health Organization Anthropometry, Daniel H. Libraty, Rosario Z. Capeding, Anamae Obcena, Job D. Brion, and Veronica Tallo

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Toll-like receptor induced pro-interleukin-1beta and interleukin-6 in monocytes are lower in healthy infants compared to adults, Daniel H. Libraty, Lei Zhang, Marcia Woda, Luz P. Acosta, Anamae Obcena, Job D. Brion, and Rosario Z. Capeding

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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection, Peter Liehl, Vanessa Zuzarte-Luis, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K. Hanson, Celine Carret, Caroline Lassnig, Mathias Muller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T. Golenbock, Birgit Strobl, Miguel Prudencio, Luis P Coelho, Stefan H. Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M. Vigario, Charles M. Rice, Katherine A. Fitzgerald, Winfried Barchet, and Maria M. Mota

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Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice, Dora Lippai, Shashi Bala, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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The role of MyD88 signaling in heterosubtypic influenza A virus infections, Rachel F. Madera and Daniel H. Libraty

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The genome of Anopheles darlingi, the main neotropical malaria vector, Osvaldo Marinotti, Adam R. Wespiser, Daniel R. Caffrey, Douglas T. Golenbock, and Neal S. Silverman

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(De-) oiling inflammasomes, Robyn Lynn Marty-Roix and Egil Lien

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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta, Bibhuti B. Mishra, Vijay A. K. Rathinam, Gregory W. Martens, Amanda J. Martinot, Hardy Kornfeld, Katherine A. Fitzgerald, and Christopher M. Sassetti

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Telomere length dynamics in human memory T cells specific for viruses causing acute or latent infections, Joel M. O'Bryan, Marcia Woda, Mary Dawn T. Co, Anuja Mathew, and Alan Rothman

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Dengue virus type 2 modulates endothelial barrier function through CD73, Chinmay Patkar, Krisanthi Giaya, and Daniel H. Libraty

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo

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Effect of Race/Ethnicity and Socioeconomic Status on Pandemic H1N1-Related Outcomes in Massachusetts, Hilary Placzek and Lawrence C. Madoff

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Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection, Nicholas Renzette, Laura L. Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, and Timothy F. Kowalik

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Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld

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Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity, Florentina Rus, Thomas Flatt, Mei Tong, Kamna Aggarwal, Kendi Okuda, Anni Kleino, Elisabeth Yates, Marc Tatar, and Neal S. Silverman

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UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major, Bruno Luiz Fonseca Schamber-Reis, Patricia M. Petritus, Braulia C. Caetano, Espiridion R. Martinez, Kendi Okuda, Douglas T. Golenbock, Phillip Scott, and Ricardo T. Gazzinelli

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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Epigenetic Modifications Induced by Blimp-1 Regulate CD8(+) T Cell Memory Progression during Acute Virus Infection, Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, and Leslie J. Berg

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Cross-reactive human B cell and T cell epitopes between influenza A and B viruses, Masanori Terajima, Jenny Aurielle B. Babon, Mary Dawn T. Co, and Francis A. Ennis

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The N-terminus of vaccinia virus host range protein C7L is essential for function, Masanori Terajima, Stina L. Urban, and Anita M. Leporati

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Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, Christine Vaine, Milan K. Patel, Jintao Zhu, Eunji Lee, Robert W. Finberg, Ryan C. Hayward, and Evelyn A. Kurt-Jones

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Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien

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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins, Donghai Wang, Susanne Hoing, Heide Christine Patterson, Umtul M. Ahmad, Vijay A. K. Rathinam, Klaus Rajewsky, Katherine A. Fitzgerald, and Douglas T. Golenbock

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Dermatophagoides pteronyssinus Major Allergen 1 Activates the Innate Immune Response of the Fruit Fly Drosophila melanogaster, Christine Warmbold, Karin Uliczka, Florentina Rus, Roland Suck, Arnd Petersen, Neal S. Silverman, Artur J. Ulmer, Holger Heine, and Thomas Roeder

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Salicylate prevents virus-induced type 1 diabetes in the BBDR rat, Chaoxing Yang, Agata Jurczyk, Philip J. diIorio, Elaine Norowski, Michael A. Brehm, Christian W. Grant, Dennis L. Guberski, Dale L. Greiner, and Rita Bortell

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CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans, Liusong Yin, J. Mauricio Calvo-Calle, John Cruz Jr., Frances K. Newman, Sharon E. Frey, Francis A. Ennis, and Lawrence J. Stern

Publications from 2012

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Cutting Edge: FAS (CD95) mediates noncanonical IL-1beta and IL-18 maturation via caspase-8 in an RIP3-independent manner, Lukas Bossaller, Ping-I Chang, Christian Schmidt-Lauber, Sandhya Ganesan, William J. Kaiser, Vijay A. K. Rathinam, Edward S. Mocarski, Deepa Subramanian, Douglas R. Green, Neal S. Silverman, Katherine A. Fitzgerald, Ann Marshak-Rothstein, and Eicke Latz

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Bacterial effectors: learning on the fly, Laurent Boyer, Nicholas Paul Paquette, Neal S. Silverman, and Lynda M. Stuart

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Immunology. Select inflammasome assembly, Daniel R. Caffrey and Katherine A. Fitzgerald

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Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope, Alex T. Chen, Markus Cornberg, Stephanie Gras, Carole Guillonneau, Jamie Rossjohn, Andrew Trees, Sebastien Emonet, Juan C. de la Torre, Raymond M. Welsh, and Liisa K. Selin

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Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome, Caroline M. Connor, Aslihan Dincer, Juerg R. Straubhaar, Janina R. Galler, Isaac B. Houston, and Schahram Akbarian

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Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells, Angela Dolganiuc, Karen Kodys, Christopher Marshall, Banishree Saha, Shuye Zhang, Shashi Bala, and Gyongyi Szabo

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The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies, Maria J. Duenas-Decamp, Olivia J. O'Connell, Davide Corti, Susan Zolla-Pazner, and Paul R. Clapham

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Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue, Maria Paz Gonzalez-Perez, Olivia O'Connell, Rongheng Lin, W. Matthew Sullivan, Jeanne E. Bell, Peter Simmonds, and Paul R. Clapham

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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1beta and neuronal toxicity, Iva Hafner-Bratkovic, Mojca Bencina, Katherine A. Fitzgerald, Douglas T. Golenbock, and Roman Jerala

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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING, Christian K. Holm, Soren B. Jensen, Martin R. Jakobsen, Natalia Cheshenko, Kristy A. Horan, Hanne B. Moeller, Regina Gonzalez-Dosal, Simon B. Rasmussen, Maria H. Christensen, Timur O. Yarovinsky, Frazer J. Rixon, Betsy C. Herold, Katherine A. Fitzgerald, and Soren R. Paludan

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation, Haifa H. Jabara, Douglas R. McDonald, Erin Janssen, Michel J. Massaad, Narayanaswamy Ramesh, Arturo Borzutzky, Ingrid Rauter, Halli Benson, Lynda Schneider, Sachin Baxi, Mike Recher, Luigi D. Notarangelo, Rima Wakim, Ghassan Dbaibo, Majed Dasouki, Waleed Al-Herz, Isil Barlan, Safa Baris, Necil Kutukculer, Hans D. Ochs, Alessandro Plebani, Maria Kanariou, Gerard Lefranc, Ismail Reisli, Katherine A. Fitzgerald, Douglas T. Golenbock, John Manis, Sevgi Keles, Reuben Ceja, Talal A. Chatila, and Raif S. Geha

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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor, Tengchuan Jin, Andrew Perry, Jiansheng Jiang, Patrick Smith, James A. Curry, Leonie Unterholzner, Zhaozhao Jiang, Gabor Horvath, Vijay A. K. Rathinam, Ricky W. Johnstone, Veit Hornung, Eicke Latz, Andrew G. Bowie, Katherine A. Fitzgerald, and T. Sam Xiao

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UnZIPping mechanisms of effector-triggered immunity in animals, Anni Kleino and Neal S. Silverman

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Viral infection: an evolving insight into the signal transduction pathways responsible for the innate immune response, Girish J. Kotwal, Steven Hatch, and William L. Marshall

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Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling, Annika Meinander, Christopher Runchel, Tencho Tenev, Li Chen, Chan-Hee Kim, Paulo S. Ribeiro, Meike Broemer, Francois Leulier, Marketa Zvelebil, Neal S. Silverman, and Pascal Meier

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Use of whole plant Artemisia annua L. as an antimalarial therapy, Elfawal Mostafa, Melissa J. Towler, Ricardo T. Gazzinelli, Douglas T. Golenbock, Pamela J. Weathers, and Stephen M. Rich

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation, Ribhu Nayar, Megan E. Enos, Amanda L. Prince, HyunMu Shin, Saskia Hemmers, Jian-kang Jiang, Ulf Klein, Craig J. Thomas, and Leslie J. Berg

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Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling, Nicholas Paul Paquette, Joseph E. Conlon, Charles R. Sweet, Florentina Rus, Lindsay Wilson, Andrea J. Pereira, Charles V. Rosadini, Nadege Goutagny, Alexander N. R. Weber, William S. Lane, Scott A. Shaffer, Stephanie Maniatis, Katherine A. Fitzgerald, Lynda M. Stuart, and Neal S. Silverman

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice, Jan Petrasek, Shashi Bala, Timea Csak, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, So-Yun Min, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice, Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, Evelyn A. Kurt-Jones, and Gyongyi Szabo