This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2010

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Structure-guided Design and Immunological Characterization of Immunogens Presenting the HIV-1 gp120 V3 Loop on a CTB Scaffold, Maxim Totrov, Xunqing Jiang, Xiang-Peng Kong, Sandra cohen, Chavdar Krachmarov, Constance Williams, Michael S. Seaman, Timothy Cardozo, Miroslaw K. Gorny, Shixia Wang, Shan Lu, Abraham Pinter, and Susan Zolla-Pazner

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Taming the symbiont for coexistence: a host PGRP neutralizes a bacterial symbiont toxin, Joshua V. Troll, Eric H. Bent, Nicholas Paul Paquette, Andrew M. Wier, William E. Goldman, Neal S. Silverman, and Margaret J. McFall-Ngai

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IFI16 is an innate immune sensor for intracellular DNA, Leonie Unterholzner, Sinead E. Keating, Marcin Baran, Kristy A. Horan, Soren B. Jensen, Shrutie Sharma, Cherilyn M. Sirois, Tengchuan Jin, Eicke Latz, T. Sam Xiao, Katherine A. Fitzgerald, Soren R. Paludan, and Andrew G. Bowie

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Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies, Michael Vaine, Shixia Wang, Qin Liu, James Arthos, David C. Montefiori, Paul Goepfert, M. Juliana McElrath, and Shan Lu

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Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling, Allison L. van Lint, Matthew R. Murawski, Rory E. Goodbody, Martina Severa, Katherine A. Fitzgerald, Robert W. Finberg, David M. Knipe, and Evelyn A. Kurt-Jones

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Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis, Stephen N. Waggoner, Ruth T. Taniguchi, Porunelloor A. Mathew, Vinay Kumar, and Raymond M. Welsh

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Heterologous immunity between viruses, Raymond M. Welsh, Jenny Wun-Yue Che, Michael A. Brehm, and Liisa K. Selin

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TLR4 is a negative regulator in noninfectious lung inflammation, Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn, and Charles A. Hales

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Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus, Shenghua Zhou, Anna M. Cerny, An Zacharia, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Robert W. Finberg

Publications from 2009

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate, Andrea Ablasser, Franz G. Bauernfeind, Gunther Hartmann, Eicke Latz, Katherine A. Fitzgerald, and Veit Hornung

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Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes, Andrea Ablasser, Hendrik Poeck, David Anz, Michael Berger, Martin Schlee, Sarah Kim, Carole Bourquin, Nadege Goutagny, Zhaozhao Jiang, Katherine A. Fitzgerald, Simon Rothenfusser, Stefan Endres, Gunther Hartmann, and Veit Hornung

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, Franz G. Bauernfeind, Gabor Horvath, Andrea Stutz, Emad S. Alnemri, Kelly MacDonald, David Speert, Teresa Fernandes-Alnemri, Jianghong Wu, Brian G. Monks, Katherine A. Fitzgerald, Veit Hornung, and Eicke Latz

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Molecular mechanisms involved in inflammasome activation, Clare Bryant and Katherine A. Fitzgerald

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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling, Leah E. Cole, Michelle H.W. Laird, Anna Seekatz, Araceli Santiago, Zhaozhao Jiang, Eileen Barry, Kari Ann Shirey, Katherine A. Fitzgerald, and Stefanie N. Vogel

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In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses, Mary Dawn T. Co, Laura Orphin, John Cruz, Pamela P. Pazoles, Karin M. Green, James A. Potts, Anita M. Leporati, Jenny Aurielle B. Babon, James E. Evans, Francis A. Ennis, and Masanori Terajima

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Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes, Deniz Erturk Hasdemir, Meike Broemer, Francois Leulier, William S. Lane, Nicholas Paul Paquette, Daye Hwang, Chan-Hee Kim, Svenja Stoven, Pascal Meier, and Neal S. Silverman

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Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo, Martin Felices, Catherine C. Yin, Yoko Kosaka, Joonsoo Kang, and Leslie J. Berg

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Integr-ating IL-1 alpha in antiviral host defenses, Katherine A. Fitzgerald

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Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection, Iiro Taneli Helenius, Thomas Krupinski, Douglas W. Turnbull, Yosef Gruenbaum, Neal S. Silverman, Eric A. Johnson, Peter H. S. Sporn, Jacob I. Sznajder, and Greg J. Beitel

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An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans, Amy G. Hise, Jeffrey Tomalka, Sandhya Ganesan, Krupen Patel, Brian A. Hall, Gordon D. Brown, and Katherine A. Fitzgerald

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC, Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz G. Bauernfeind, Gabor Horvath, Daniel R. Caffrey, Eicke Latz, and Katherine A. Fitzgerald

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Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Jennifer P. Wang, Charles A. Specht, and Stuart M. Levitz

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Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice, Smita Jaiswal, Todd Pearson, Heather Friberg, Leonard D. Shultz, Dale L. Greiner, Alan L. Rothman, and Anuja Mathew

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The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling, Ingvild B. Johnsen, Thuy Thanh Nguyen, Bjarte Bergstroem, Katherine A. Fitzgerald, and Marit W. Anthonsen

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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus, Sybille Kenzel, Sandra Santos-Sierra, Sachin D. Deshmukh, Inga Moeller, Bilge Ergin, Katherine A. Fitzgerald, Egil Lien, Shizuo Akira, Douglas T. Golenbock, and Phillip Henneke

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP, Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhiliang Cheng, Katherine A. Fitzgerald, Yoshihiro Hayakawa, and Russell E. Vance

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Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR, Nishaki Mehta, Sonia Trzmielina, Bareng A. S. Nonyane, Melissa N. Eliot, Rongheng Lin, Andrea S. Foulkes, Kristina McNeal, Arthur Ammann, Vindu Eulalievyolo, John L. Sullivan, Katherine Luzuriaga, and Mohan Somasundaran

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TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade, David M. Miller, Thomas B. Thornley, Todd Pearson, Annie J. Kruger, Masahiro Yamazaki, Leonard D. Shultz, Raymond M. Welsh, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling, Kamalpreet Nagpal, Theo S. Plantinga, Joyce Wong, Brian G. Monks, Nicholas J. Gay, Mihai G. Netea, Katherine A. Fitzgerald, and Douglas T. Golenbock

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NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis, Amit K. Pandey, Yibin Yang, Zhaozhao Jiang, Sarah M. Fortune, Francois Coulombe, Marcel A. Behr, Katherine A. Fitzgerald, Christopher M. Sassetti, and Michelle A. Kelliher

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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling, Wenji Piao, Chang Song, Haiyan Chen, Marco A. Quevedo Diaz, Larry M. Wahl, Katherine A. Fitzgerald, Liwu Li, and Andrei E. Medvedev

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The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development, Amanda L. Prince, Catherine C. Yin, Megan E. Enos, Martin Felices, and Leslie J. Berg

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus, Martin Schlee, Andreas Roth, Veit Hornung, Christina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, and Gunther Hartmann

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Novel mechanistic insights into viral modulation of immune receptor signaling, Alexander B. Sigalov

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Specificity and Signaling in the Drosophila Immune Response, Neal S. Silverman, Nicholas Paul Paquette, and Kamna Aggarwal

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Topographic analysis of individual activation patterns in medial frontal cortex in schizophrenia, Emily R. Stern, Robert C. Welsh, Katherine A. Fitzgerald, and Stephan F. Taylor

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Inflammasomes: too big to miss, Andrea Stutz, Douglas T. Golenbock, and Eicke Latz

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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K, Yu Sun, Minako Ishibashi, Tracie Seimon, Mingsum Lee, Sudarshana M. Sharma, Katherine A. Fitzgerald, Andriy O. Samokhin, Yibin Wang, Scott Sayers, Masanori Aikawa, W. Gray Jerome, Michael C. Ostrowski, Dieter Bromme, Peter Libby, Ira A. Tabas, Carrie L. Welch, and Alan R. Tall

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Peptidoglycan induces loss of a nuclear peptidoglycan recognition protein during host tissue development in a beneficial animal-bacterial symbiosis, Joshua V. Troll, Dawn M. Adin, Andrew M. Wier, Nicholas Paul Paquette, Neal S. Silverman, William E. Goldman, Frank J. Stadermann, Eric V. Stabb, and Margaret J. McFall-Ngai

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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling, Connie W. Woo, Dongying Cui, Jerry Arellano, Bernhard Dorweiler, Heather Harding, Katherine A. Fitzgerald, David Ron, and Ira Tabas

Publications from 2008

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Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway, Kamna Aggarwal, Florentina Rus, Christie Vriesema-Magnuson, Deniz Erturk Hasdemir, Nicholas Paquette, and Neal S. Silverman

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Positive and negative regulation of the Drosophila immune response, Kamna Aggarwal and Neal S. Silverman

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Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

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Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi, Daniella C. Bartholomeu, Catherine Ropert, Mariane B. Melo, Peggy Parroche, Caroline F. Junqueira, Santuza M. R. Teixeira, Cherilyn M. Sirois, Pia Kasperkovitz, Cathrine F. Knetter, Egil Lien, Eicke Latz, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA, Marie Charrel-Dennis, Eicke Latz, Kristen A. Halmen, Patrick Trieu-Cuot, Katherine A. Fitzgerald, Dennis L. Kasper, and Douglas T. Golenbock

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A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts, Anne-Danielle C. Chessler, Ludmila R. Ferreira P., Tun-Han Chang, Katherine A. Fitzgerald, and Barbara A. Burleigh

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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens, Karim C. El Kasmi, Joseph E. Qualls, John T. Pesce, Amber M. Smith, Robert W. Thompson, Marcela Henao-Tamayo, Randall J. Basaraba, Till Konig, Ulrike Schleicher, Mi-Sun Koo, Gilla Kaplan, Katherine A. Fitzgerald, Elaine I. Tuomanen, Ian M. Orme, Thirumala-Devi Kanneganti, Christian Bogdan, Thomas A. Wynn, and Peter J. Murray

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Hormonal regulation of the humoral innate immune response in Drosophila melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, and Neal S. Silverman

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Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling, Felix Geeraedts, Nadege Goutagny, Veit Hornung, Martina Severa, Aalzen de Haan, Judity Pool, Jan Wilschut, Katherine A. Fitzgerald, and Anke Huckriede

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta, Annett Halle, Veit Hornung, Gabor C. Petzold, Cameron R. Stewart, Brian G. Monks, Thomas Reinheckel, Katherine A. Fitzgerald, Eicke Latz, Kathryn J. Moore, and Douglas T. Golenbock

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The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Rowan Higgs, Joan Ni Gabhann, Nadia Ben Larbi, Eamon P. Breen, Katherine A. Fitzgerald, and Caroline A. Jefferies

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Veit Hornung, Franz G. Bauernfeind, Annett Halle, Eivind O. Samstad, Hajime Kono, Kenneth L. Rock, Katherine A. Fitzgerald, and Eicke Latz

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Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein, Xueqiao Liu, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, Robert W. Finberg, and David M. Knipe

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Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein: implications for the mechanism of fusion promotion, Paul J. Mahon, Anne M. Mirza, Thomas A. Musich, and Ronald M. Iorio

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Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus, Anuja Mathew, Joel M. O'Bryan, William L. Marshall, Girish J. Kotwal, Masanori Terajima, Sharone Green, Alan L. Rothman, and Francis A. Ennis

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Role of innate immunity in transplantation tolerance., David M. Miller, Aldo A. Rossini, and Dale L. Greiner

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Viral infection: a potent barrier to transplantation tolerance, David M. Miller, Thomas B. Thornley, Dale L. Greiner, and Aldo A. Rossini

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TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance., David M. Miller, Thomas B. Thornley, Todd Pearson, Masahiro Yamazaki, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

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Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response, Andrea Paun, Jorgen T. Reinert, Zhaozhao Jiang, Carey L. Medin, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

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Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment, Todd Pearson, Leonard D. Shultz, David M. Miller, Marie A. King, Joseph Laning, William Fodor, Amy Cuthbert, Lisa M. Burzenski, Bruce Gott, Bonnie L. Lyons, Oded Foreman, Aldo A. Rossini, and Dale L. Greiner

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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance, Wenji Piao, Chang Song, Haiyan Chen, Larry M. Wahl, Katherine A. Fitzgerald, Luke A. J. O'Neill, and Andrei E. Medvedev

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Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA, Zaida G. Ramirez-Ortiz, Charles A. Specht, Jennifer P. Wang, Chrono K. Lee, Daniella C. Bartholomeu, Ricardo T. Gazzinelli, and Stuart M. Levitz

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Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens, Pavlo V. Sakhatskyy, Shixia Wang, Chuanyou Zhang, Te-Hui Chou, Michael G. Kishko, and Shan Lu

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Immunology. The right resident bugs, Neal S. Silverman and Nicholas Paul Paquette

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Hepatitis C and innate immunity: recent advances, Gyongyi Szabo and Angela Dolganiuc

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Open-label, dose escalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A, Claribel P. Taylor, Hemachand Tummala, Deborah Molrine, Lisa Davidson, Richard J. Farrell, Anthony J. Lembo, Patricia L. Hibberd, Israel Lowy, and Ciaran P. Kelly

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Improved induction of antibodies against key neutralizing epitopes by HIV-1 gp120 DNA prime-protein boost vaccination compared to gp120 protein only vaccination, Michael Vaine, Shixia Wang, Emma T. Crooks, Pengfei Jiang, David C. Montefiori, James Binley, and Shan Lu

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Class II major histocompatibility complex tetramer staining: progress, problems, and prospects, Sabrina S. Vollers and Lawrence J. Stern

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Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components, Karen L. Wozniak and Stuart M. Levitz

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Autophagic control of listeria through intracellular innate immune recognition in drosophila, Tamaki Yano, Shizuka Mita, Hiroko Ohmori, Yoshiteru Oshima, Yukari Fujimoto, Ryu Ueda, Haruhiko Takada, William E. Goldman, Koichi Fukase, Neal S. Silverman, Tamotsu Yoshimori, and Shoichiro Kurata

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Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses, Shenghua Zhou, Annett Halle, Evelyn A. Kurt-Jones, Anna M. Cerny, Ermelinda Porpiglia, Michael Rogers, Douglas Golenbock, and Robert W. Finberg

Publications from 2007

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Peptidoglycan recognition in Drosophila, Kamna Aggarwal and Neal S. Silverman

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RIG-I: tri-ing to discriminate between self and non-self RNA, Andrew G. Bowie and Katherine A. Fitzgerald

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Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif, Pamela Cook, Sabine Totemeyer, Catherine Stevenson, Katherine A. Fitzgerald, Masahiro Yamamoto, Shizuo Akira, Duncan J. Maskell, and Clare E. Bryant

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Bug Versus Bug: Humoral Immune Responses in Drosophila melanogaster, Deniz Erturk Hasdemir, Nicholas Paul Paquette, Kamna Aggarwal, and Neal S. Silverman

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Immunology. The shape of things to come, Katherine A. Fitzgerald and Douglas T. Golenbock

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CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help, Maria Genevieve H. Hernandez, Lianjun Shen, and Kenneth L. Rock

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Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM, Amy G. Hise, Katrin Daehnel, Illona Gillette-Ferguson, Eun Cho, Helen F. McGarry, Mark J. Taylor, Douglas T. Golenbock, Katherine A. Fitzgerald, James W. Kazura, and Eric Pearlman

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Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity, Marie A. King, Todd Pearson, Leonard D. Shultz, Jean H. Leif, Rita Bottino, Massimo Trucco, Mark A. Atkinson, Clive Wasserfall, Kevan C. Herold, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene, Marie A. King, Todd Pearson, Leonard D. Shultz, Jean H. Leif, Rita Bottino, Massimo Trucco, Mark A. Atkinson, Clive Wasserfall, Kevan C. Herold, Robert T. Woodland, Madelyn R. Schmidt, Bruce A. Woda, Michael J. Thompson, Aldo A. Rossini, and Dale L. Greiner

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9, Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M. Sirois, Dionne C. G. Klein, Brian G. Monks, C. James McKnight, Marc S. Lamphier, W. Paul Duprex, Terje Espevik, and Douglas T. Golenbock

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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1, Sinead M. Miggin, Eva M. Palsson-McDermott, Aisling Dunne, Caroline A. Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwell, Douglas T. Golenbock, Katherine A. Fitzgerald, and Luke A. J. O'Neill

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Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA, Marie-Louise Newell, Sharon Huang, Simona Fiore, Claire Thorne, Laurent Mandelbrot, John L. Sullivan, Robert Maupin, Isaac Delke, D. Heather Watts, Richard D. Gelber, and Colleen K. Cunningham

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The role of type I interferons in TLR responses, Susie J. Noppert, Katherine A. Fitzgerald, and Paul J. Hertzog

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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis, Zachary J. Roberts, Nadege Goutagny, Pin-Yu Perera, Hiroki Kato, Himanshu Kumar, Taro Kawai, Shizuo Akira, Ram Savan, David van Echo, Katherine A. Fitzgerald, Howard A. Young, Lai-Ming Ching, and Stefanie N. Vogel

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TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war, Martina Severa and Katherine A. Fitzgerald

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YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction, Charles R. Sweet, Joseph E. Conlon, Douglas T. Golenbock, Jon D. Goguen, and Neal S. Silverman

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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE, Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas T. Golenbock, Cherilyn M. Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K. Crow, Katherine A. Fitzgerald, Eicke Latz, Peter A. Kiener, and Anthony J. Coyle

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Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses, Charles Fenton Towne, Ian A. York, Levi B. Watkin, John S. Lazo, and Kenneth L. Rock

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Fighting infection fly-style, Louisa Wu and Neal S. Silverman

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Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice, Masahiro Yamazaki, Todd Pearson, Michael A. Brehm, David M. Miller, Julie A. Mangada, Thomas G. Markees, Leonard D. Shultz, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection, Shenghua Zhou, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Jennifer P. Wang, Anna M. Cerny, Melvin Chan, and Robert W. Finberg

Publications from 2006

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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals, Chun-Jen Chen, Yan Shi, Arron Hearn, Katherine A. Fitzgerald, Douglas T. Golenbock, George W. Reed, Shizuo Akira, and Kenneth L. Rock

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Host-pathogen interactions in drosophila: new tricks from an old friend, Sara Cherry and Neal S. Silverman

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Sorting out Toll signals, Katherine A. Fitzgerald and Zhijian J. Chen

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Pattern recognition receptors: an update, Nadege Goutagny and Katherine A. Fitzgerald

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Pin-ning down immune responses to RNA viruses, Nadege Goutagny, Martina Severa, and Katherine A. Fitzgerald

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PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan, Takashi Kaneko, Tamaki Yano, Kamna Aggarwal, Jae-Hong Lim, Kazunori Ueda, Yoshiteru Oshima, Camilla Peach, Deniz Erturk Hasdemir, William E. Goldman, Byung-Ha Oh, Shoichiro Kurata, and Neal S. Silverman

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Integrity of membrane lipid rafts is necessary for the ordered assembly and release of infectious Newcastle disease virus particles, Jason P. Laliberte, Lori McGinnes, Mark E. Peeples, and Trudy G. Morrison

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TLR9 and the recognition of self and non-self nucleic acids, Marc S. Lamphier, Cherilyn M. Sirois, Anjali Verma, Douglas T. Golenbock, and Eicke Latz