This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2010

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz

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NLR-containing inflammasomes: central mediators of host defense and inflammation, Katherine A. Fitzgerald

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Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein, Nadege Goutagny, Zhaozhao Jiang, Jane Tian, Peggy Parroche, Jeanne Schickli, Brian G. Monks, Nancy Ulbrandt, Hong Ji, Peter A. Kiener, Anthony J. Coyle, and Katherine A. Fitzgerald

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Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling, Pearl Gray, Kathrin S. Michelsen, Cherilyn M. Sirois, Emily Lowe, Kenichi Shimada, Timothy R. Crother, Shuang Chen, Constantinos Brikos, Yonca Bulut, Eicke Latz, David Underhill, and Moshe Arditi

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Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded beta-Glucan Particles, Habin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Automated Detection of Infectious Disease Outbreaks in Hospitals: A Retrospective Cohort Study, Susan S. Huang, Deborah S. Yokoe, John Stelling, Hilary Placzek, Martin Kulldorff, Ken Kleinman, Thomas F. O'Brien, Michael S. Calderwood, Johanna Vostok, Julie Dunn, and Richard Platt

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Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome, Sarah Kim, Franz G. Bauernfeind, Andrea Ablasser, Gunther Hartmann, Katherine A. Fitzgerald, Eicke Latz, and Veit Hornung

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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts, Oliver Kumpf, Evangelos J. Giamarellos-Bourboulis, Alexander Koch, Lutz Hamann, Maria Mouktaroudi, Djin-Ye Oh, Eicke Latz, Eva Lorenz, David A. Schwartz, Bart Ferwerda, Christina Routsi, Chryssanthi Skalioti, Bart-Jan Kullberg, Jos W. M. van der Meer, Peter M. Schlag, Mihai G. Netea, Kai Zacharowski, and Ralf R. Schumann

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Innate recognition of fungal cell walls, Stuart M. Levitz

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The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement, Lisa A. Lewis, Jutamas Ngampasutadol, Ruth Wallace, Jane E. A. Reid, Ulrich Vogel, and Sanjay Ram

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Reduction of Vertical Transmission of HIV in the Dominican Republic: Benefits of Early Presentation for Prenatal Care, Ingrid Liff, Mario Alejandro Chevalier, Arachu Castro, and Raul E. Davaro

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Detecting microRNA activity from gene expression data, Stephen F. Madden, Susan B. Carpenter, Ian B. Jeffery, Harry Bjorkbacka, Katherine A. Fitzgerald, Luke A. J. O'Neill, and Desmond G. Higgins

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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality, Erica Marchlik, Paresh Thakker, Thaddeus Carlson, Zhaozhao Jiang, Mark Ryan, Suzana Marusic, Nadege Goutagny, Wen Kuang, G. Roger Askew, Victoria Roberts, Stephen Benoit, Tianhui Zhou, Vincent Ling, Richard Pfeifer, Nancy Stedman, Katherine A. Fitzgerald, Lih-Ling Lin, and J. Perry Hall

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions, Heather D. Marshall, Amanda L. Prince, Leslie J. Berg, and Raymond M. Welsh

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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4, Edel A. McNeela, Aine Burke, Daniel R. Neill, Cathy Baxter, Vitor E. Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M. McLoughlin, Andres Mori, Barry Moran, Katherine A. Fitzgerald, Jurg Tschopp, Virginie Petrilli, Peter W. Andrew, Aras Kadioglu, and Ed C. Lavelle

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Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e., Christian Mueller, Allison M. Keeler, Sofia Braag, Timothy Menz, Qiushi Tang, and Terence R. Flotte

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Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment, Kavitha Narayan and Joonso Kang

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Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3), Thuy Thanh Nguyen, Ingvild B. Johnsen, Catherine F. Knetter, Finn Drablos, Katherine A. Fitzgerald, Egil Lien, and Marit W. Anthonsen

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NOD1 and NOD2 mediate sensing of periodontal pathogens, T. Okugawa, Takashi Kaneko, A. Yoshimura, Neal S. Silverman, and Y. Hara

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Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus, Ravichandran Panchanathan, Xin Dua, Hui Shen, Vijay A.K. Rathinam, Loren D. Erickson, Katherine A. Fitzgerald, and Divaker Choubey

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Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling, Nicholas Paul Paquette, Meike Broemer, Kamna Aggarwal, Li Chen, Marie Husson, Deniz Erturk Hasdemir, Jean-Marc Reichhart, Pascal Meier, and Neal S. Silverman

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The use of immunization registry-based data in vaccine effectiveness studies, Hilary Placzek and Lawrence C. Madoff

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Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators, James A. Potts, Robert V. Gibbons, Alan L. Rothman, Anon Srikiatkhachorn, Stephen J. Thomas, Pra-On Supradish, Stephenie C. Lemon, Daniel H. Libraty, Sharone Green, and Siripen Kalayanarooj

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Classification of dengue illness based on readily available laboratory data, James A. Potts, Stephen J. Thomas, Anon Srikiatkhachorn, Pra-On Supradish, Wenjun Li, Ananda Nisalak, Suchitra Nimmannitya, Timothy P. Endy, Daniel H. Libraty, Robert V. Gibbons, Sharone Green, Alan Rothman, and Siripen Kalayanarooj

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Inflammasomes and anti-viral immunity, Vijay A.K. Rathinam and Katherine A. Fitzgerald

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald

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Catenin' on to nucleic acid sensing, Vijay A.K. Rathinam, Shrutie Sharma, and Katherine A. Fitzgerald

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Viral defense: it takes two MAVS to Tango, Shrutie Sharma and Katherine A. Fitzgerald

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern

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Altered effector functions of virus-specific and virus cross-reactive CD8+ T cells in mice immunized with related flaviviruses., Derek W. Trobaugh, Liyan Yang, Francis A. Ennis, and Sharone Green

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Taming the symbiont for coexistence: a host PGRP neutralizes a bacterial symbiont toxin, Joshua V. Troll, Eric H. Bent, Nicholas Paul Paquette, Andrew M. Wier, William E. Goldman, Neal S. Silverman, and Margaret J. McFall-Ngai

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IFI16 is an innate immune sensor for intracellular DNA, Leonie Unterholzner, Sinead E. Keating, Marcin Baran, Kristy A. Horan, Soren B. Jensen, Shrutie Sharma, Cherilyn M. Sirois, Tengchuan Jin, Eicke Latz, T. Sam Xiao, Katherine A. Fitzgerald, Soren R. Paludan, and Andrew G. Bowie

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Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies, Michael Vaine, Shixia Wang, Qin Liu, James Arthos, David C. Montefiori, Paul Goepfert, M. Juliana McElrath, and Shan Lu

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Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling, Allison L. van Lint, Matthew R. Murawski, Rory E. Goodbody, Martina Severa, Katherine A. Fitzgerald, Robert W. Finberg, David M. Knipe, and Evelyn A. Kurt-Jones

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Heterologous immunity between viruses, Raymond M. Welsh, Jenny Wun-Yue Che, Michael A. Brehm, and Liisa K. Selin

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TLR4 is a negative regulator in noninfectious lung inflammation, Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn, and Charles A. Hales

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Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus, Shenghua Zhou, Anna M. Cerny, An Zacharia, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Robert W. Finberg

Publications from 2009

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate, Andrea Ablasser, Franz G. Bauernfeind, Gunther Hartmann, Eicke Latz, Katherine A. Fitzgerald, and Veit Hornung

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Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes, Andrea Ablasser, Hendrik Poeck, David Anz, Michael Berger, Martin Schlee, Sarah Kim, Carole Bourquin, Nadege Goutagny, Zhaozhao Jiang, Katherine A. Fitzgerald, Simon Rothenfusser, Stefan Endres, Gunther Hartmann, and Veit Hornung

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, Franz G. Bauernfeind, Gabor Horvath, Andrea Stutz, Emad S. Alnemri, Kelly MacDonald, David Speert, Teresa Fernandes-Alnemri, Jianghong Wu, Brian G. Monks, Katherine A. Fitzgerald, Veit Hornung, and Eicke Latz

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Molecular mechanisms involved in inflammasome activation, Clare Bryant and Katherine A. Fitzgerald

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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling, Leah E. Cole, Michelle H.W. Laird, Anna Seekatz, Araceli Santiago, Zhaozhao Jiang, Eileen Barry, Kari Ann Shirey, Katherine A. Fitzgerald, and Stefanie N. Vogel

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In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses, Mary Dawn T. Co, Laura Orphin, John Cruz, Pamela P. Pazoles, Karin M. Green, James A. Potts, Anita M. Leporati, Jenny Aurielle B. Babon, James E. Evans, Francis A. Ennis, and Masanori Terajima

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Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes, Deniz Erturk Hasdemir, Meike Broemer, Francois Leulier, William S. Lane, Nicholas Paul Paquette, Daye Hwang, Chan-Hee Kim, Svenja Stoven, Pascal Meier, and Neal S. Silverman

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Integr-ating IL-1 alpha in antiviral host defenses, Katherine A. Fitzgerald

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Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells, Luiz C. Godoy, Cristina Muñoz-Pinedo, Laura Castro, Simone Cardaci, Christopher M. Schonhoff, Michael King, Verónica Tórtora, Mónica Marín, Qian Miao, Jian Fei Jiang, Alexandr Kapralov, Ronald Jemmerson, Gary G. Silkstone, Jinal N. Patel, James E. Evans, Michael T. Wilson, Douglas R. Green, Valerian E. Kagan, Rafael Radi, and Joan B. Mannick

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Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection, Iiro Taneli Helenius, Thomas Krupinski, Douglas W. Turnbull, Yosef Gruenbaum, Neal S. Silverman, Eric A. Johnson, Peter H. S. Sporn, Jacob I. Sznajder, and Greg J. Beitel

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An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans, Amy G. Hise, Jeffrey Tomalka, Sandhya Ganesan, Krupen Patel, Brian A. Hall, Gordon D. Brown, and Katherine A. Fitzgerald

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC, Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz G. Bauernfeind, Gabor Horvath, Daniel R. Caffrey, Eicke Latz, and Katherine A. Fitzgerald

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Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Jennifer P. Wang, Charles A. Specht, and Stuart M. Levitz

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Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice, Smita Jaiswal, Todd Pearson, Heather Friberg, Leonard D. Shultz, Dale L. Greiner, Alan L. Rothman, and Anuja Mathew

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The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling, Ingvild B. Johnsen, Thuy Thanh Nguyen, Bjarte Bergstroem, Katherine A. Fitzgerald, and Marit W. Anthonsen

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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus, Sybille Kenzel, Sandra Santos-Sierra, Sachin D. Deshmukh, Inga Moeller, Bilge Ergin, Katherine A. Fitzgerald, Egil Lien, Shizuo Akira, Douglas T. Golenbock, and Phillip Henneke

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP, Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhiliang Cheng, Katherine A. Fitzgerald, Yoshihiro Hayakawa, and Russell E. Vance

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TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade, David M. Miller, Thomas B. Thornley, Todd Pearson, Annie J. Kruger, Masahiro Yamazaki, Leonard D. Shultz, Raymond M. Welsh, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling, Kamalpreet Nagpal, Theo S. Plantinga, Joyce Wong, Brian G. Monks, Nicholas J. Gay, Mihai G. Netea, Katherine A. Fitzgerald, and Douglas T. Golenbock

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NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis, Amit K. Pandey, Yibin Yang, Zhaozhao Jiang, Sarah M. Fortune, Francois Coulombe, Marcel A. Behr, Katherine A. Fitzgerald, Christopher M. Sassetti, and Michelle A. Kelliher

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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling, Wenji Piao, Chang Song, Haiyan Chen, Marco A. Quevedo Diaz, Larry M. Wahl, Katherine A. Fitzgerald, Liwu Li, and Andrei E. Medvedev

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The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development, Amanda L. Prince, Catherine C. Yin, Megan E. Enos, Martin Felices, and Leslie J. Berg

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus, Martin Schlee, Andreas Roth, Veit Hornung, Christina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, and Gunther Hartmann

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Functional comparison of the binding of factor H short consensus repeat 6 (SCR 6) to factor H binding protein from Neisseria meningitidis and the binding of factor H SCR 18 to 20 to Neisseria gonorrhoeae porin, Jutamas Shaughnessy, Lisa A. Lewis, Hanna Jarva, and Sanjay Ram

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Specificity and Signaling in the Drosophila Immune Response, Neal S. Silverman, Nicholas Paul Paquette, and Kamna Aggarwal

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Topographic analysis of individual activation patterns in medial frontal cortex in schizophrenia, Emily R. Stern, Robert C. Welsh, Katherine A. Fitzgerald, and Stephan F. Taylor

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Inflammasomes: too big to miss, Andrea Stutz, Douglas T. Golenbock, and Eicke Latz

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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K, Yu Sun, Minako Ishibashi, Tracie Seimon, Mingsum Lee, Sudarshana M. Sharma, Katherine A. Fitzgerald, Andriy O. Samokhin, Yibin Wang, Scott Sayers, Masanori Aikawa, W. Gray Jerome, Michael C. Ostrowski, Dieter Bromme, Peter Libby, Ira A. Tabas, Carrie L. Welch, and Alan R. Tall

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Peptidoglycan induces loss of a nuclear peptidoglycan recognition protein during host tissue development in a beneficial animal-bacterial symbiosis, Joshua V. Troll, Dawn M. Adin, Andrew M. Wier, Nicholas Paul Paquette, Neal S. Silverman, William E. Goldman, Frank J. Stadermann, Eric V. Stabb, and Margaret J. McFall-Ngai

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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling, Connie W. Woo, Dongying Cui, Jerry Arellano, Bernhard Dorweiler, Heather Harding, Katherine A. Fitzgerald, David Ron, and Ira Tabas

Publications from 2008

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Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway, Kamna Aggarwal, Florentina Rus, Christie Vriesema-Magnuson, Deniz Erturk Hasdemir, Nicholas Paquette, and Neal S. Silverman

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Positive and negative regulation of the Drosophila immune response, Kamna Aggarwal and Neal S. Silverman

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Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

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Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi, Daniella C. Bartholomeu, Catherine Ropert, Mariane B. Melo, Peggy Parroche, Caroline F. Junqueira, Santuza M. R. Teixeira, Cherilyn M. Sirois, Pia Kasperkovitz, Cathrine F. Knetter, Egil Lien, Eicke Latz, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA, Marie Charrel-Dennis, Eicke Latz, Kristen A. Halmen, Patrick Trieu-Cuot, Katherine A. Fitzgerald, Dennis L. Kasper, and Douglas T. Golenbock

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A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts, Anne-Danielle C. Chessler, Ludmila R. Ferreira P., Tun-Han Chang, Katherine A. Fitzgerald, and Barbara A. Burleigh

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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens, Karim C. El Kasmi, Joseph E. Qualls, John T. Pesce, Amber M. Smith, Robert W. Thompson, Marcela Henao-Tamayo, Randall J. Basaraba, Till Konig, Ulrike Schleicher, Mi-Sun Koo, Gilla Kaplan, Katherine A. Fitzgerald, Elaine I. Tuomanen, Ian M. Orme, Thirumala-Devi Kanneganti, Christian Bogdan, Thomas A. Wynn, and Peter J. Murray

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Hormonal regulation of the humoral innate immune response in Drosophila melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, and Neal S. Silverman

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Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling, Felix Geeraedts, Nadege Goutagny, Veit Hornung, Martina Severa, Aalzen de Haan, Judity Pool, Jan Wilschut, Katherine A. Fitzgerald, and Anke Huckriede

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta, Annett Halle, Veit Hornung, Gabor C. Petzold, Cameron R. Stewart, Brian G. Monks, Thomas Reinheckel, Katherine A. Fitzgerald, Eicke Latz, Kathryn J. Moore, and Douglas T. Golenbock

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The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Rowan Higgs, Joan Ni Gabhann, Nadia Ben Larbi, Eamon P. Breen, Katherine A. Fitzgerald, and Caroline A. Jefferies

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Veit Hornung, Franz G. Bauernfeind, Annett Halle, Eivind O. Samstad, Hajime Kono, Kenneth L. Rock, Katherine A. Fitzgerald, and Eicke Latz

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Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling, Vishal Jain, Annett Halle, Kristen A. Halmen, Egil Lien, Marie Charrel-Dennis, Sanjay Ram, Douglas T. Golenbock, and Alberto Visintin

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Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein, Xueqiao Liu, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, Robert W. Finberg, and David M. Knipe

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Measurement of protein S-nitrosylation during cell signaling, Joan B. Mannick and Christopher M. Schonhoff

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Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus, Anuja Mathew, Joel M. O'Bryan, William L. Marshall, Girish J. Kotwal, Masanori Terajima, Sharone Green, Alan L. Rothman, and Francis A. Ennis

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Role of innate immunity in transplantation tolerance., David M. Miller, Aldo A. Rossini, and Dale L. Greiner

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Viral infection: a potent barrier to transplantation tolerance, David M. Miller, Thomas B. Thornley, Dale L. Greiner, and Aldo A. Rossini

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TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance., David M. Miller, Thomas B. Thornley, Todd Pearson, Masahiro Yamazaki, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

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Respiratory syncytial virus activates innate immunity through Toll-like receptor 2, Matthew R. Murawski, Glennice N. Bowen, Anna M. Cerny, Larry J. Anderson, Lia M. Haynes, Ralph A. Tripp, Evelyn A. Kurt-Jones, and Robert W. Finberg

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Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion, Jutamas Ngampasutadol, Sanjay Ram, Sunita Gulati, Sarika Agarwal, Chongqing Li, Alberto Visintin, Brian G. Monks, Guillermo E. Madico, and Peter A. Rice

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Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response, Andrea Paun, Jorgen T. Reinert, Zhaozhao Jiang, Carey L. Medin, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

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Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment, Todd Pearson, Leonard D. Shultz, David M. Miller, Marie A. King, Joseph Laning, William Fodor, Amy Cuthbert, Lisa M. Burzenski, Bruce Gott, Bonnie L. Lyons, Oded Foreman, Aldo A. Rossini, and Dale L. Greiner

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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance, Wenji Piao, Chang Song, Haiyan Chen, Larry M. Wahl, Katherine A. Fitzgerald, Luke A. J. O'Neill, and Andrei E. Medvedev

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Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations, James A. Potts and Alan L. Rothman

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Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA, Zaida G. Ramirez-Ortiz, Charles A. Specht, Jennifer P. Wang, Chrono K. Lee, Daniella C. Bartholomeu, Ricardo T. Gazzinelli, and Stuart M. Levitz

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Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens, Pavlo V. Sakhatskyy, Shixia Wang, Chuanyou Zhang, Te-Hui Chou, Michael G. Kishko, and Shan Lu

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Immunology. The right resident bugs, Neal S. Silverman and Nicholas Paul Paquette

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Improved induction of antibodies against key neutralizing epitopes by HIV-1 gp120 DNA prime-protein boost vaccination compared to gp120 protein only vaccination, Michael Vaine, Shixia Wang, Emma T. Crooks, Pengfei Jiang, David C. Montefiori, James Binley, and Shan Lu

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Toll-like receptor-mediated activation of neutrophils by influenza A virus, Jennifer P. Wang, Glennice N. Bowen, Carolyn Padden, Anna M. Cerny, Robert W. Finberg, Peter E. Newburger, and Evelyn A. Kurt-Jones

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Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers, Shixia Wang, Jeffrey S. Kennedy, Kim West, David C. Montefiori, Scott E. Coley, John M. Lawrence, Siyuan Shen, Sharone Green, Alan L. Rothman, Francis A. Ennis, James Arthos, Ranajit Pal, Phillip Markham, and Shan Lu