This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2013

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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta, Bibhuti B. Mishra, Vijay A. K. Rathinam, Gregory W. Martens, Amanda J. Martinot, Hardy Kornfeld, Katherine A. Fitzgerald, and Christopher M. Sassetti

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Telomere length dynamics in human memory T cells specific for viruses causing acute or latent infections, Joel M. O'Bryan, Marcia Woda, Mary Dawn T. Co, Anuja Mathew, and Alan Rothman

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Dengue virus type 2 modulates endothelial barrier function through CD73, Chinmay Patkar, Krisanthi Giaya, and Daniel H. Libraty

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo

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Effect of Race/Ethnicity and Socioeconomic Status on Pandemic H1N1-Related Outcomes in Massachusetts, Hilary Placzek and Lawrence C. Madoff

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Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection, Nicholas Renzette, Laura L. Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, and Timothy F. Kowalik

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Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld

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Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity, Florentina Rus, Thomas Flatt, Mei Tong, Kamna Aggarwal, Kendi Okuda, Anni Kleino, Elisabeth Yates, Marc Tatar, and Neal S. Silverman

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UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major, Bruno Luiz Fonseca Schamber-Reis, Patricia M. Petritus, Braulia C. Caetano, Espiridion R. Martinez, Kendi Okuda, Douglas T. Golenbock, Phillip Scott, and Ricardo T. Gazzinelli

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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Epigenetic Modifications Induced by Blimp-1 Regulate CD8(+) T Cell Memory Progression during Acute Virus Infection, Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, and Leslie J. Berg

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Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1beta response and host resistance to Trypanosoma cruzi infection, Grace Kelly Silva, Renata Sesti Costa, Tatiana Nunes Silveira, Braulia C. Caetano, Catarina Veltrini Horta, Fredy Roberto Gutierrez-Salazar, Paulo Marcos da Matta Guedes, Warrison A. Andrade, Mariana De Niz, Ricardo T. Gazzinelli, Dario Simoes Zamboni, and Joao Santana Silva

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Cross-reactive human B cell and T cell epitopes between influenza A and B viruses, Masanori Terajima, Jenny Aurielle B. Babon, Mary Dawn T. Co, and Francis A. Ennis

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The N-terminus of vaccinia virus host range protein C7L is essential for function, Masanori Terajima, Stina L. Urban, and Anita M. Leporati

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Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, Christine Vaine, Milan K. Patel, Jintao Zhu, Eunji Lee, Robert W. Finberg, Ryan C. Hayward, and Evelyn A. Kurt-Jones

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Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien

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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins, Donghai Wang, Susanne Hoing, Heide Christine Patterson, Umtul M. Ahmad, Vijay A. K. Rathinam, Klaus Rajewsky, Katherine A. Fitzgerald, and Douglas T. Golenbock

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Dermatophagoides pteronyssinus Major Allergen 1 Activates the Innate Immune Response of the Fruit Fly Drosophila melanogaster, Christine Warmbold, Karin Uliczka, Florentina Rus, Roland Suck, Arnd Petersen, Neal S. Silverman, Artur J. Ulmer, Holger Heine, and Thomas Roeder

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CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans, Liusong Yin, J. Mauricio Calvo-Calle, John Cruz Jr., Frances K. Newman, Sharon E. Frey, Francis A. Ennis, and Lawrence J. Stern

Publications from 2012

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Cutting Edge: FAS (CD95) mediates noncanonical IL-1beta and IL-18 maturation via caspase-8 in an RIP3-independent manner, Lukas Bossaller, Ping-I Chang, Christian Schmidt-Lauber, Sandhya Ganesan, William J. Kaiser, Vijay A. K. Rathinam, Edward S. Mocarski, Deepa Subramanian, Douglas R. Green, Neal S. Silverman, Katherine A. Fitzgerald, Ann Marshak-Rothstein, and Eicke Latz

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Bacterial effectors: learning on the fly, Laurent Boyer, Nicholas Paul Paquette, Neal S. Silverman, and Lynda M. Stuart

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Immunology. Select inflammasome assembly, Daniel R. Caffrey and Katherine A. Fitzgerald

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Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome, Caroline M. Connor, Aslihan Dincer, Juerg R. Straubhaar, Janina R. Galler, Isaac B. Houston, and Schahram Akbarian

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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1beta and neuronal toxicity, Iva Hafner-Bratkovic, Mojca Bencina, Katherine A. Fitzgerald, Douglas T. Golenbock, and Roman Jerala

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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING, Christian K. Holm, Soren B. Jensen, Martin R. Jakobsen, Natalia Cheshenko, Kristy A. Horan, Hanne B. Moeller, Regina Gonzalez-Dosal, Simon B. Rasmussen, Maria H. Christensen, Timur O. Yarovinsky, Frazer J. Rixon, Betsy C. Herold, Katherine A. Fitzgerald, and Soren R. Paludan

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation, Haifa H. Jabara, Douglas R. McDonald, Erin Janssen, Michel J. Massaad, Narayanaswamy Ramesh, Arturo Borzutzky, Ingrid Rauter, Halli Benson, Lynda Schneider, Sachin Baxi, Mike Recher, Luigi D. Notarangelo, Rima Wakim, Ghassan Dbaibo, Majed Dasouki, Waleed Al-Herz, Isil Barlan, Safa Baris, Necil Kutukculer, Hans D. Ochs, Alessandro Plebani, Maria Kanariou, Gerard Lefranc, Ismail Reisli, Katherine A. Fitzgerald, Douglas T. Golenbock, John Manis, Sevgi Keles, Reuben Ceja, Talal A. Chatila, and Raif S. Geha

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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor, Tengchuan Jin, Andrew Perry, Jiansheng Jiang, Patrick Smith, James A. Curry, Leonie Unterholzner, Zhaozhao Jiang, Gabor Horvath, Vijay A. K. Rathinam, Ricky W. Johnstone, Veit Hornung, Eicke Latz, Andrew G. Bowie, Katherine A. Fitzgerald, and T. Sam Xiao

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UnZIPping mechanisms of effector-triggered immunity in animals, Anni Kleino and Neal S. Silverman

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Viral infection: an evolving insight into the signal transduction pathways responsible for the innate immune response, Girish J. Kotwal, Steven Hatch, and William L. Marshall

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Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling, Annika Meinander, Christopher Runchel, Tencho Tenev, Li Chen, Chan-Hee Kim, Paulo S. Ribeiro, Meike Broemer, Francois Leulier, Marketa Zvelebil, Neal S. Silverman, and Pascal Meier

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Use of whole plant Artemisia annua L. as an antimalarial therapy, Elfawal Mostafa, Melissa J. Towler, Ricardo T. Gazzinelli, Douglas T. Golenbock, Pamela J. Weathers, and Stephen M. Rich

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation, Ribhu Nayar, Megan E. Enos, Amanda L. Prince, HyunMu Shin, Saskia Hemmers, Jian-kang Jiang, Ulf Klein, Craig J. Thomas, and Leslie J. Berg

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Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling, Nicholas Paul Paquette, Joseph E. Conlon, Charles R. Sweet, Florentina Rus, Lindsay Wilson, Andrea J. Pereira, Charles V. Rosadini, Nadege Goutagny, Alexander N. R. Weber, William S. Lane, Scott A. Shaffer, Stephanie Maniatis, Katherine A. Fitzgerald, Lynda M. Stuart, and Neal S. Silverman

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice, Jan Petrasek, Shashi Bala, Timea Csak, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, So-Yun Min, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice, Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential, Daniel Prantner, Darren J. Perkins, Wendy Lai, Mark S. Williams, Shrutie Sharma, Katherine A. Fitzgerald, and Stefanie N. Vogel

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Defective pro-IL-1beta responses in macrophages from aged mice, Alejandor Ramirez, Vijay A. K. Rathinam, Katherine A. Fitzgerald, Douglas T. Golenbock, and Anuja Mathew

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Regulation of inflammasome signaling, Vijay A. K. Rathinam, Sivapriya Kailasan Vanaja, and Katherine A. Fitzgerald

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria, Vijay A. K. Rathinam, Sivapriya Kailasan Vanaja, Lisa Waggoner, Anna Sokolovska, Christine Becker, Lynda M. Stuart, John M. Leong, and Katherine A. Fitzgerald

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Immune responses in cystic fibrosis: are they intrinsically defective?, Dmitry Ratner and Christian Mueller

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Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathways, Florentina Rus, Kayla Morlock, Neal S. Silverman, Ngoc Pham, Girish J. Kotwal, and William L. Marshall

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TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia, Andrea Scharfe-Nugent, Sinead C. Corr, Susan B. Carpenter, Louise Keogh, Brendan Doyle, Cara Martin, Katherine A. Fitzgerald, Sean Daly, John J. O'Leary, and Luke A. J. O'Neill

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Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction, Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang, Juraj Kabat, Abu-Asab Mones, Katherine A. Fitzgerald, Alan Sher, and John H. Kehrl

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Kenichi Shimada, Timothy R. Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V. Krishnan Ramanujan, Andrea J. Wolf, Laurent Vergnes, David M. Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A. Fitzgerald, David M. Underhill, Terrence Town, and Moshe Arditi

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CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2, Roy J. Soberman, Christopher R. MacKay, Christine A. Vaine, Glennice Bowen Ryan, Anna M. Cerny, Mikayla R. Thompson, Boris Nikolic, Valeria Primo, Peter Christmas, Paul Sheiffele, Lisa Aronov, David M. Knipe, and Evelyn A. Kurt-Jones

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Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status, Anon Srikiatkhachorn, Sineewanlaya Wichit, Robert V. Gibbons, Sharone Green, Daniel H. Libraty, Timothy P. Endy, Francis A. Ennis, Siripen Kalayanarooj, and Alan L. Rothman

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Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger

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The NLRP12 Inflammasome Recognizes Yersinia pestis, Gregory I. Vladimer, Dan Weng, Sara W. Montminy Paquette, Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Marie Hjelmseth Aune, Joseph E. Conlon, Joseph J. Burbage, Megan K. Proulx, Qin Liu, George W. Reed, Joan C. Mecsas, Yoichiro Iwakura, John Bertin, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien

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Effect of a Multidisciplinary Team Approach to Eradicate Central Line Associated Blood-Stream Infections (CLABSI), J. Matthias Walz, Richard T. Ellison III, Helen Flaherty, John McIlwaine, Deborah Ann Mack, Kathleen Whyte, Karen Landry, Stephen P. Baker, Stephen O. Heard, and CCOC Research Group

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Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants, Jennifer P. Wang, Lei Zhang, Rachel F. Madera, Marcia Woda, and Daniel H. Libraty

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Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates, Shixia Wang, Michael G. Kishko, Shengqin Wan, Yan Wang, Frank E. Brewster, Glenda E. Gray, Avye Violari, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and Shan Lu

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CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone, James L. Young, Alfonso Mora, Anna M. Cerny, Michael P. Czech, Bruce A. Woda, Evelyn A. Kurt-Jones, Robert W. Finberg, and Silvia Corvera

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Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection, Shenghua Zhou, Anna M. Cerny, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Robert W. Finberg

Publications from 2011

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Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice, Jennifer L. Ather, Karina Ckless, Rebecca Martin, Kathryn L. Foley, Benjamin T. Suratt, Jonathan E. Boyson, Katherine A. Fitzgerald, Richard A. Flavell, Stephanie C. Eisenbarth, and Matthew E. Poynter

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Host genetic risk factors for West Nile virus infection and disease progression, Abigail W. Bigham, Kati J. Buckingham, Sofia Husain, Mary J. Edmond, Kathryn M. Bofferding, Heidi Gildersleeve, Ann Rutherford, Natalia M. Astakhova, Andrey A. Perelygin, Michael P. Busch, Kristy O. Murray, James J. Sejvar, Sharone Green, John Kriesel, Margo A. Brinton, and Michael Bamshad

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Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway, Laurent Boyer, Lorin Magoc, Stephanie Dejardin, Michael Cappillino, Nicholas Paul Paquette, Charlotte Hinault, Guillaume M. Charriere, W. K. Eddie Ip, Shannon Fracchia, Elizabeth Hennessy, Deniz Erturk Hasdemir, Jean-Marc Reichhart, Neal S. Silverman, Adam Lucy-Hulbert, and Lynda M. Stuart

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Pelvic inflammatory disease, Thomas L. Cherpes, Peter A. Rice, and Richard L. Sweet

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Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway, Peihong Dai, Hua Cao, Taha Merghoub, Francesca Avogadri, Weiyi Wang, Tanvi Parikh, Chee-Mun Fang, Paula M. Pitha, Katherine A. Fitzgerald, Masmudur M. Rahman, Grant McFadden, Xiaoyu Hu, Alan N. Houghton, Stewart Shuman, and Liang Deng

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An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus, Xiaofei E., Mary Theresa Pickering, Michelle E. Debatis, Jonathan Patrick Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, and Timothy F. Kowalik

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The interferon inducible gene: Viperin, Katherine A. Fitzgerald

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NF-kappaB/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster, Sandhya Ganesan, Kamna Aggarwal, Nicholas Paul Paquette, and Neal S. Silverman

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Lessons from the Field: Parasite DNA Drives the Innate Immune Response to Malaria (it's not just the caiparinhas), Douglas Golenbock

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Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines, Sharone Green, Francis A. Ennis, and Anuja Mathew

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Autophagy controls IL-1{beta} secretion by targeting pro-IL-1{beta} for degradation, James Harris, Michelle L. Hartman, Caitrionna Roche, Shijuan G. Zeng, Amy O'Shea, Fiona Sharp, Eimear M. Lambe, Emma M. Creagh, Douglas T. Golenbock, Jurg Tschopp, Hardy Kornfeld, Katherine A. Fitzgerald, and Ed C. Lavelle

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Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study, Susan S. Huang, Rupak Datta, Sheryl L. Rifas-Shiman, Ken P. Kleinman, Hilary Placzek, Julie Lankiewicz, and Richard Platt

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Mice completely lacking immunoproteasomes show major changes in antigen presentation, Eleanor Z. Kincaid, Jenny Wun-Yue Che, Ian York, Hernando Escobar, Eduardo Reyes-Vargas, Julio C. Delgado, Raymond M. Welsh, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, and Kenneth L. Rock

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T-cell responses to dengue virus in humans, Ichiro Kurane, Takaji Matsutani, Ryuji Suzuki, Tomohiko Takasaki, Siripen Kalayanarooj, Sharone Green, Alan L. Rothman, and Francis A. Ennis

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Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection, Jun Li, Yaping Han, Ke Jin, Yufeng Wan, Shixia Wang, Bo Liu, Yuan Liu, Shan Lu, and Zuhu Huang

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The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses, Rachel F. Madera, Jennifer P. Wang, and Daniel H. Libraty

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A new approach to monitoring dengue activity, Lawrence C. Madoff, David N. Fisman, and Taha Kass-Hout

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B-cell responses during primary and secondary dengue virus infections in humans, Anuja Mathew, Kim West, Siripen Kalayanarooj, Robert V. Gibbons, Anon Srikiatkhachorn, Sharone Green, Daniel H. Libraty, Smita Jaiswal, and Alan L. Rothman

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A natural loss-of-function mutation of MyD88 disrupts its ability to form Myddosomes, Kamalpreet Nagpal, Theo S. Plantinga, Cherilyn M. Sirois, Brian G. Monks, Eicke Latz, Mihai G. Netea, and Douglas T. Golenbock

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A.K. Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C. lam, Joshua A. Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim, Katherine A. Fitzgerald, Stefan W. Ryter, and Augustine M. K. Choi

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Recognition of herpesviruses by the innate immune system, Soren R. Paludan, Andrew G. Bowie, Kristy A. Horan, and Katherine A. Fitzgerald

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Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fc{gamma} Receptor (Fc{gamma}RIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein, Ravichandran Panchanathan, Hui Shen, Xin Duan, Vijay A. K. Rathinam, Loren D. Erickson, Katherine A. Fitzgerald, and Divaker Choubey

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Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract, Dane Parker, Francis J. Martin, Grace Soong, Bryan S. Harfenist, Jorge L. Aguilar, Adam J. Ratner, Katherine A. Fitzgerald, Christian Schindler, and Alice Prince

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Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells, Jan Petrasek, Angela Dolganiuc, Timea Csak, Bharath D. Nath, Istvan Hritz, Karen Kodys, Donna Catalano, Evelyn A. Kurt-Jones, Pranoti Mandrekar, and Gyongyi Szabo

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Identification of Influenza Cases During the H1N1 Pandemic in Massachusetts Using Population-Based Hospital Discharge Data, Hilary Placzek and Lawrence C. Madoff

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Innate immune sensing of DNA viruses, Vijay A.K. Rathinam and Katherine A. Fitzgerald

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Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

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The PYHIN protein family as mediators of host defenses, Stefan A. Schattgen and Katherine A. Fitzgerald

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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome, Shrutie Sharma, Rosane B. DeOliveira, Parisa Kalantari, Peggy Parroche, Nadege Goutagny, Zhaozhao Jiang, Jennie Chan, Daniella C. Bartholomeu, Fanny N. Lauw, J. Perry Hall, Glen N. Barber, Ricardo T. Gazzinelli, Katherine A. Fitzgerald, and Douglas T. Golenbock

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Innate immune sensing of DNA, Shrutie Sharma and Katherine A. Fitzgerald

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Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis, Sergey A. Shiryaev, Piotr Cieplak, Alexander E. Aleshin, Qing Sun, Wenhong Zhu, Khatereh Motamedchaboki, Alexander Sloutsky, and Alex Y. Strongin

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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-(beta) and RANTES production, Jakub Siednienko, Thusitha Gajanayake, Katherine A. Fitzgerald, Paul Moynagh, and Sinead M. Miggin

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Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection, Barbara S. Stewart, Valerie L. Demarest, Susan J. Wong, Sharone Green, and Kristen A. Bernard

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Pattern recognition receptors and the innate immune response to viral infection, Mikayla R. Thompson, John J. Kaminski III, Evelyn A. Kurt-Jones, and Katherine A. Fitzgerald

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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans, Jeffrey Tomalka, Sandhya Ganesan, Elaheh Azodi, Krupen Patel, Parth Majmudar, Brian A. Hall, Katherine A. Fitzgerald, and Amy G. Hise

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Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates, Michael Vaine, Maria J. Duenas-Decamp, Paul J. Peters, Qin Liu, James Arthos, Shixia Wang, Paul R. Clapham, and Shan Lu

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Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans, Jennifer P. Wang, Chrono K. Lee, Ali Akalin, Robert W. Finberg, and Stuart M. Levitz

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Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM, Lijian Wang, Estela Trebicka, Ying Fu, Lisa Waggoner, Shizuo Akira, Katherine A. Fitzgerald, Jonathan C. Kagan, and Bobby J. Cherayil

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ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae, Sandy M. S. Wong, Frank St. Michael, Andrew Cox, Sanjay Ram, and Brian J. Akerley

Publications from 2010

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IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome, Christian Bauer, Peter Duewell, Christine Mayer, Hans Anton Lehr, Katherine A. Fitzgerald, Marc Dauer, Jurg Tschopp, Stefan Endres, Eicke Latz, and Max Schnurr

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Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters, Guillaume M. Charriere, Wk Eddie Ip, Stephanie Dejardin, Laurent Boyer, Anna Sokolovska, Michael P. Cappillino, Bobby J. Cherayil, Daniel K. Podolsky, Koichi S. Kobayashi, Neal S. Silverman, Adam Lacy-Hulbert, and Lynda M. Stuart

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz