This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

Follow


Publications from 2011

PDF

Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study, Susan S. Huang, Rupak Datta, Sheryl L. Rifas-Shiman, Ken P. Kleinman, Hilary Placzek, Julie Lankiewicz, and Richard Platt

Link

Mice completely lacking immunoproteasomes show major changes in antigen presentation, Eleanor Z. Kincaid, Jenny Wun-Yue Che, Ian York, Hernando Escobar, Eduardo Reyes-Vargas, Julio C. Delgado, Raymond M. Welsh, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, and Kenneth L. Rock

PDF

Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga

PDF

Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages, Jinhee Lee, Teresa Repasy, Kadamba Papavinasasundaram, Christopher M. Sassetti, and Hardy Kornfeld

PDF

Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection, Jun Li, Yaping Han, Ke Jin, Yufeng Wan, Shixia Wang, Bo Liu, Yuan Liu, Shan Lu, and Zuhu Huang

PDF

The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses, Rachel F. Madera, Jennifer P. Wang, and Daniel H. Libraty

PDF

A new approach to monitoring dengue activity, Lawrence C. Madoff, David N. Fisman, and Taha Kass-Hout

PDF

Cytotoxic CD4 T cells in antiviral immunity, Nikki B. Marshall and Susan L. Swain

Link

A natural loss-of-function mutation of MyD88 disrupts its ability to form Myddosomes, Kamalpreet Nagpal, Theo S. Plantinga, Cherilyn M. Sirois, Brian G. Monks, Eicke Latz, Mihai G. Netea, and Douglas T. Golenbock

Link

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A.K. Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C. lam, Joshua A. Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim, Katherine A. Fitzgerald, Stefan W. Ryter, and Augustine M. K. Choi

Link

Recognition of herpesviruses by the innate immune system, Soren R. Paludan, Andrew G. Bowie, Kristy A. Horan, and Katherine A. Fitzgerald

Link

Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fc{gamma} Receptor (Fc{gamma}RIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein, Ravichandran Panchanathan, Hui Shen, Xin Duan, Vijay A. K. Rathinam, Loren D. Erickson, Katherine A. Fitzgerald, and Divaker Choubey

PDF

Inhibition of TLR8- and TLR4-induced Type I IFN Induction by Alcohol is Different from its effects on inflammatory cytokine production in monocytes, Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, and Gyongyi Szabo

PDF

Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract, Dane Parker, Francis J. Martin, Grace Soong, Bryan S. Harfenist, Jorge L. Aguilar, Adam J. Ratner, Katherine A. Fitzgerald, Christian Schindler, and Alice Prince

Link

Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

Link

Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells, Jan Petrasek, Angela Dolganiuc, Timea Csak, Bharath D. Nath, Istvan Hritz, Karen Kodys, Donna Catalano, Evelyn A. Kurt-Jones, Pranoti Mandrekar, and Gyongyi Szabo

PDF

Identification of Influenza Cases During the H1N1 Pandemic in Massachusetts Using Population-Based Hospital Discharge Data, Hilary Placzek and Lawrence C. Madoff

Link

Innate immune sensing of DNA viruses, Vijay A.K. Rathinam and Katherine A. Fitzgerald

PDF

Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

Link

The PYHIN protein family as mediators of host defenses, Stefan A. Schattgen and Katherine A. Fitzgerald

PDF

Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure, Mark E. Sharkey, Dunja Z. Babic, Thomas C. Greenough, Roy Gulick, Daniel R. Kuritzkes, and Mario Stevenson

Link

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome, Shrutie Sharma, Rosane B. DeOliveira, Parisa Kalantari, Peggy Parroche, Nadege Goutagny, Zhaozhao Jiang, Jennie Chan, Daniella C. Bartholomeu, Fanny N. Lauw, J. Perry Hall, Glen N. Barber, Ricardo T. Gazzinelli, Katherine A. Fitzgerald, and Douglas T. Golenbock

PDF

Innate immune sensing of DNA, Shrutie Sharma and Katherine A. Fitzgerald

Link

Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis, Sergey A. Shiryaev, Piotr Cieplak, Alexander E. Aleshin, Qing Sun, Wenhong Zhu, Khatereh Motamedchaboki, Alexander Sloutsky, and Alex Y. Strongin

Link

Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-(beta) and RANTES production, Jakub Siednienko, Thusitha Gajanayake, Katherine A. Fitzgerald, Paul Moynagh, and Sinead M. Miggin

PDF

Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection, Barbara S. Stewart, Valerie L. Demarest, Susan J. Wong, Sharone Green, and Kristen A. Bernard

PDF

Pattern recognition receptors and the innate immune response to viral infection, Mikayla R. Thompson, John J. Kaminski III, Evelyn A. Kurt-Jones, and Katherine A. Fitzgerald

PDF

A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans, Jeffrey Tomalka, Sandhya Ganesan, Elaheh Azodi, Krupen Patel, Parth Majmudar, Brian A. Hall, Katherine A. Fitzgerald, and Amy G. Hise

PDF

Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans, Jennifer P. Wang, Chrono K. Lee, Ali Akalin, Robert W. Finberg, and Stuart M. Levitz

Link

Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM, Lijian Wang, Estela Trebicka, Ying Fu, Lisa Waggoner, Shizuo Akira, Katherine A. Fitzgerald, Jonathan C. Kagan, and Bobby J. Cherayil

PDF

ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae, Sandy M. S. Wong, Frank St. Michael, Andrew Cox, Sanjay Ram, and Brian J. Akerley

Publications from 2010

Link

IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

PDF

Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression, Angika Basant, Mayuri Rege, Shobhona Sharma, and Haripalsingh M. Sonawat

Link

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome, Christian Bauer, Peter Duewell, Christine Mayer, Hans Anton Lehr, Katherine A. Fitzgerald, Marc Dauer, Jurg Tschopp, Stefan Endres, Eicke Latz, and Max Schnurr

Link

Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters, Guillaume M. Charriere, Wk Eddie Ip, Stephanie Dejardin, Laurent Boyer, Anna Sokolovska, Michael P. Cappillino, Bobby J. Cherayil, Daniel K. Podolsky, Koichi S. Kobayashi, Neal S. Silverman, Adam Lacy-Hulbert, and Lynda M. Stuart

Link

Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

Link

CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

Link

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz

Link

NLR-containing inflammasomes: central mediators of host defense and inflammation, Katherine A. Fitzgerald

Link

Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein, Nadege Goutagny, Zhaozhao Jiang, Jane Tian, Peggy Parroche, Jeanne Schickli, Brian G. Monks, Nancy Ulbrandt, Hong Ji, Peter A. Kiener, Anthony J. Coyle, and Katherine A. Fitzgerald

Link

Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling, Pearl Gray, Kathrin S. Michelsen, Cherilyn M. Sirois, Emily Lowe, Kenichi Shimada, Timothy R. Crother, Shuang Chen, Constantinos Brikos, Yonca Bulut, Eicke Latz, David Underhill, and Moshe Arditi

PDF

Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded beta-Glucan Particles, Habin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

PDF

Automated Detection of Infectious Disease Outbreaks in Hospitals: A Retrospective Cohort Study, Susan S. Huang, Deborah S. Yokoe, John Stelling, Hilary Placzek, Martin Kulldorff, Ken Kleinman, Thomas F. O'Brien, Michael S. Calderwood, Johanna Vostok, Julie Dunn, and Richard Platt

Link

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome, Sarah Kim, Franz G. Bauernfeind, Andrea Ablasser, Gunther Hartmann, Katherine A. Fitzgerald, Eicke Latz, and Veit Hornung

PDF

Uric acid promotes an acute inflammatory response to sterile cell death in mice, Hajime Kono, Chun-Jen Chen, Fernando Ontiveros, and Kenneth L. Rock

PDF

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts, Oliver Kumpf, Evangelos J. Giamarellos-Bourboulis, Alexander Koch, Lutz Hamann, Maria Mouktaroudi, Djin-Ye Oh, Eicke Latz, Eva Lorenz, David A. Schwartz, Bart Ferwerda, Christina Routsi, Chryssanthi Skalioti, Bart-Jan Kullberg, Jos W. M. van der Meer, Peter M. Schlag, Mihai G. Netea, Kai Zacharowski, and Ralf R. Schumann

PDF

Innate recognition of fungal cell walls, Stuart M. Levitz

PDF

The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement, Lisa A. Lewis, Jutamas Ngampasutadol, Ruth Wallace, Jane E. A. Reid, Ulrich Vogel, and Sanjay Ram

PDF

Detecting microRNA activity from gene expression data, Stephen F. Madden, Susan B. Carpenter, Ian B. Jeffery, Harry Bjorkbacka, Katherine A. Fitzgerald, Luke A. J. O'Neill, and Desmond G. Higgins

Link

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality, Erica Marchlik, Paresh Thakker, Thaddeus Carlson, Zhaozhao Jiang, Mark Ryan, Suzana Marusic, Nadege Goutagny, Wen Kuang, G. Roger Askew, Victoria Roberts, Stephen Benoit, Tianhui Zhou, Vincent Ling, Richard Pfeifer, Nancy Stedman, Katherine A. Fitzgerald, Lih-Ling Lin, and J. Perry Hall

Link

IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions, Heather D. Marshall, Amanda L. Prince, Leslie J. Berg, and Raymond M. Welsh

PDF

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4, Edel A. McNeela, Aine Burke, Daniel R. Neill, Cathy Baxter, Vitor E. Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M. McLoughlin, Andres Mori, Barry Moran, Katherine A. Fitzgerald, Jurg Tschopp, Virginie Petrilli, Peter W. Andrew, Aras Kadioglu, and Ed C. Lavelle

Link

Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e., Christian Mueller, Allison M. Keeler, Sofia Braag, Timothy Menz, Qiushi Tang, and Terence R. Flotte

Link

Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment, Kavitha Narayan and Joonso Kang

Link

Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3), Thuy Thanh Nguyen, Ingvild B. Johnsen, Catherine F. Knetter, Finn Drablos, Katherine A. Fitzgerald, Egil Lien, and Marit W. Anthonsen

Link

NOD1 and NOD2 mediate sensing of periodontal pathogens, T. Okugawa, Takashi Kaneko, A. Yoshimura, Neal S. Silverman, and Y. Hara

Link

Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus, Ravichandran Panchanathan, Xin Dua, Hui Shen, Vijay A.K. Rathinam, Loren D. Erickson, Katherine A. Fitzgerald, and Divaker Choubey

Link

Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling, Nicholas Paul Paquette, Meike Broemer, Kamna Aggarwal, Li Chen, Marie Husson, Deniz Erturk Hasdemir, Jean-Marc Reichhart, Pascal Meier, and Neal S. Silverman

PDF

The use of immunization registry-based data in vaccine effectiveness studies, Hilary Placzek and Lawrence C. Madoff

PDF

Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators, James A. Potts, Robert V. Gibbons, Alan L. Rothman, Anon Srikiatkhachorn, Stephen J. Thomas, Pra-On Supradish, Stephenie C. Lemon, Daniel H. Libraty, Sharone Green, and Siripen Kalayanarooj

PDF

Maturation-dependent licensing of naive T cells for rapid TNF production, Bhavana Priyadharshini, Raymond M. Welsh, Dale L. Greiner, Rachel M. Gerstein, and Michael A. Brehm

Link

Inflammasomes and anti-viral immunity, Vijay A.K. Rathinam and Katherine A. Fitzgerald

Link

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald

Link

Catenin' on to nucleic acid sensing, Vijay A.K. Rathinam, Shrutie Sharma, and Katherine A. Fitzgerald

Link

Viral defense: it takes two MAVS to Tango, Shrutie Sharma and Katherine A. Fitzgerald

Link

Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern

Link

Structure-guided Design and Immunological Characterization of Immunogens Presenting the HIV-1 gp120 V3 Loop on a CTB Scaffold, Maxim Totrov, Xunqing Jiang, Xiang-Peng Kong, Sandra cohen, Chavdar Krachmarov, Constance Williams, Michael S. Seaman, Timothy Cardozo, Miroslaw K. Gorny, Shixia Wang, Shan Lu, Abraham Pinter, and Susan Zolla-Pazner

Link

Taming the symbiont for coexistence: a host PGRP neutralizes a bacterial symbiont toxin, Joshua V. Troll, Eric H. Bent, Nicholas Paul Paquette, Andrew M. Wier, William E. Goldman, Neal S. Silverman, and Margaret J. McFall-Ngai

Link

IFI16 is an innate immune sensor for intracellular DNA, Leonie Unterholzner, Sinead E. Keating, Marcin Baran, Kristy A. Horan, Soren B. Jensen, Shrutie Sharma, Cherilyn M. Sirois, Tengchuan Jin, Eicke Latz, T. Sam Xiao, Katherine A. Fitzgerald, Soren R. Paludan, and Andrew G. Bowie

PDF

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies, Michael Vaine, Shixia Wang, Qin Liu, James Arthos, David C. Montefiori, Paul Goepfert, M. Juliana McElrath, and Shan Lu

Link

Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling, Allison L. van Lint, Matthew R. Murawski, Rory E. Goodbody, Martina Severa, Katherine A. Fitzgerald, Robert W. Finberg, David M. Knipe, and Evelyn A. Kurt-Jones

PDF

Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis, Stephen N. Waggoner, Ruth T. Taniguchi, Porunelloor A. Mathew, Vinay Kumar, and Raymond M. Welsh

Link

Heterologous immunity between viruses, Raymond M. Welsh, Jenny Wun-Yue Che, Michael A. Brehm, and Liisa K. Selin

Link

TLR4 is a negative regulator in noninfectious lung inflammation, Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn, and Charles A. Hales

Link

Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus, Shenghua Zhou, Anna M. Cerny, An Zacharia, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Robert W. Finberg

Publications from 2009

Link

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate, Andrea Ablasser, Franz G. Bauernfeind, Gunther Hartmann, Eicke Latz, Katherine A. Fitzgerald, and Veit Hornung

Link

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes, Andrea Ablasser, Hendrik Poeck, David Anz, Michael Berger, Martin Schlee, Sarah Kim, Carole Bourquin, Nadege Goutagny, Zhaozhao Jiang, Katherine A. Fitzgerald, Simon Rothenfusser, Stefan Endres, Gunther Hartmann, and Veit Hornung

Link

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression, Franz G. Bauernfeind, Gabor Horvath, Andrea Stutz, Emad S. Alnemri, Kelly MacDonald, David Speert, Teresa Fernandes-Alnemri, Jianghong Wu, Brian G. Monks, Katherine A. Fitzgerald, Veit Hornung, and Eicke Latz

Link

Molecular mechanisms involved in inflammasome activation, Clare Bryant and Katherine A. Fitzgerald

Link

Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling, Leah E. Cole, Michelle H.W. Laird, Anna Seekatz, Araceli Santiago, Zhaozhao Jiang, Eileen Barry, Kari Ann Shirey, Katherine A. Fitzgerald, and Stefanie N. Vogel

Link

In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses, Mary Dawn T. Co, Laura Orphin, John Cruz, Pamela P. Pazoles, Karin M. Green, James A. Potts, Anita M. Leporati, Jenny Aurielle B. Babon, James E. Evans, Francis A. Ennis, and Masanori Terajima

Link

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes, Deniz Erturk Hasdemir, Meike Broemer, Francois Leulier, William S. Lane, Nicholas Paul Paquette, Daye Hwang, Chan-Hee Kim, Svenja Stoven, Pascal Meier, and Neal S. Silverman

PDF

Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo, Martin Felices, Catherine C. Yin, Yoko Kosaka, Joonsoo Kang, and Leslie J. Berg

Link

Integr-ating IL-1 alpha in antiviral host defenses, Katherine A. Fitzgerald

Link

Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection, Iiro Taneli Helenius, Thomas Krupinski, Douglas W. Turnbull, Yosef Gruenbaum, Neal S. Silverman, Eric A. Johnson, Peter H. S. Sporn, Jacob I. Sznajder, and Greg J. Beitel

Link

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans, Amy G. Hise, Jeffrey Tomalka, Sandhya Ganesan, Krupen Patel, Brian A. Hall, Gordon D. Brown, and Katherine A. Fitzgerald

Link

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC, Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz G. Bauernfeind, Gabor Horvath, Daniel R. Caffrey, Eicke Latz, and Katherine A. Fitzgerald

Link

Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Jennifer P. Wang, Charles A. Specht, and Stuart M. Levitz

PDF

Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice, Smita Jaiswal, Todd Pearson, Heather Friberg, Leonard D. Shultz, Dale L. Greiner, Alan L. Rothman, and Anuja Mathew

Link

The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling, Ingvild B. Johnsen, Thuy Thanh Nguyen, Bjarte Bergstroem, Katherine A. Fitzgerald, and Marit W. Anthonsen

Link

Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus, Sybille Kenzel, Sandra Santos-Sierra, Sachin D. Deshmukh, Inga Moeller, Bilge Ergin, Katherine A. Fitzgerald, Egil Lien, Shizuo Akira, Douglas T. Golenbock, and Phillip Henneke

Link

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP, Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhiliang Cheng, Katherine A. Fitzgerald, Yoshihiro Hayakawa, and Russell E. Vance

PDF

Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR, Nishaki Mehta, Sonia Trzmielina, Bareng A. S. Nonyane, Melissa N. Eliot, Rongheng Lin, Andrea S. Foulkes, Kristina McNeal, Arthur Ammann, Vindu Eulalievyolo, John L. Sullivan, Katherine Luzuriaga, and Mohan Somasundaran

Link

TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade, David M. Miller, Thomas B. Thornley, Todd Pearson, Annie J. Kruger, Masahiro Yamazaki, Leonard D. Shultz, Raymond M. Welsh, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

Link

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling, Kamalpreet Nagpal, Theo S. Plantinga, Joyce Wong, Brian G. Monks, Nicholas J. Gay, Mihai G. Netea, Katherine A. Fitzgerald, and Douglas T. Golenbock

PDF

NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis, Amit K. Pandey, Yibin Yang, Zhaozhao Jiang, Sarah M. Fortune, Francois Coulombe, Marcel A. Behr, Katherine A. Fitzgerald, Christopher M. Sassetti, and Michelle A. Kelliher

Link

Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling, Wenji Piao, Chang Song, Haiyan Chen, Marco A. Quevedo Diaz, Larry M. Wahl, Katherine A. Fitzgerald, Liwu Li, and Andrei E. Medvedev

Link

The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development, Amanda L. Prince, Catherine C. Yin, Megan E. Enos, Martin Felices, and Leslie J. Berg

Link

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus, Martin Schlee, Andreas Roth, Veit Hornung, Christina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, and Gunther Hartmann

PDF

Novel mechanistic insights into viral modulation of immune receptor signaling, Alexander B. Sigalov