This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2014

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Interferon gamma-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses, Mikayla R. Thompson, Shrutie Sharma, Maninjay K. Atianand, Soren B. Jensen, Susan B. Carpenter, David M. Knipe, Katherine A. Fitzgerald, and Evelyn A. Kurt-Jones

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A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis, Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, and David A Thorley-Lawson

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HTT-lowering reverses Huntington's disease immune dysfunction caused by NFkappaB pathway dysregulation, Ulrike Trager, Ralph Andre, Nayana Lahiri, Anna Magnusson-Lind, Andreas Weiss, Stephan Grueninger, Chris McKinnon, Eva Sirinathsinghji, Shira Kahlon, Edith L. Pfister, Roger Moser, Holger Hummerich, Michael Antoniou, Gillian P. Bates, Ruth Luthi-Carter, Mark W. Lowdell, Maria Bjorkqvist, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Multifocal Rhizopus microsporus lung infection following brush clearing, Artsiom V. Tsyrkunou, Richard T. Ellison III, Ali Akalin, Nathan Wiederhold, Deanna A. Sutton, Jonathan Lindner, Hongxin Fan, Stuart M. Levitz, and Iva Zivna

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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome, Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian M. Skehan, Katherine A. Fitzgerald, and John M. Leong

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

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TRIL is involved in cytokine production in the brain following Escherichia coli infection, Paulina Wochal, Vijay A. K. Rathinam, Aisling Dunne, Thaddeus Carlson, Wen Kuang, Katherine J. Seidl, J. Perry Hall, Lih-Ling Lin, Mary Collins, Stefan A. Schattgen, Christopher R. MacKay, Caio T. Fagundes, Susan B. Carpenter, Katherine A. Fitzgerald, and Luke A. J. O'Neill

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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors, Seng-Ryong Woo, Mercedes B. Fuertes, Leticia Corrales, Stefani Spranger, Michael J. Furdyna, Michael Y. K. Leung, Ryan Duggan, Ying Wang, Glen N. Barber, Katherine A. Fitzgerald, Maria-Luisa Alegre, and Thomas F. Gajewski

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A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination, Liusong Yin and Lawrence J. Stern

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Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization, Liusong Yin and Lawrence J. Stern

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Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide, Liusong Yin, Peter Trenh, Abigail I. Guce, Marek Wieczorek, Sascha Lange, Jana Sticht, Wei Jiang, Marissa Bylsma, Elizabeth D. Mellins, Christian Freund, and Lawrence J. Stern

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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING, Lu Zhang, Jinyao Mo, Karen V. Swanson, Haitao Wen, Alex Petrucelli, Sean M. Gregory, Zhigang Zhang, Monika Schneider, Yan Jiang, Katherine A. Fitzgerald, Songying Ouyang, Zhi-Jie Liu, Blossom Damania, Hong-Bing Shu, Joseph A. Duncan, and Jenny P-Y Ting

Publications from 2013

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Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome, Ali A. Abdul-Sater, Ivan Tattoli, Lei Jin, Andrzej Grajkowski, Assaf Levi, Beverly H. Koller, Irving C. Allen, Serge L. Beaucage, Katherine A. Fitzgerald, Jenny P-Y. Ting, John C. Cambier, Stephen E. Girardin, and Christian Schindler

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Cross reactivity of serum antibody responses elicited by DNA vaccines expressing HA antigens from H1N1 subtype influenza vaccines in the past 30 years, Iman Almansour, Huaiqing Chen, Shixia Wang, and Shan Lu

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Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice, Warrison A. Andrade, Maria do Carmo Souza, Espiridion Ramos-Martinez, Kamalpreet Nagpal, Miriam S. Dutra, Mariane B. Melo, Daniella C. Bartholomeu, Sankar Ghosh, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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Molecular basis of DNA recognition in the immune system, Maninjay K. Atianand and Katherine A. Fitzgerald

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SnapShot: inflammasomes, Maninjay K. Atianand, Vijay A. K. Rathinam, and Katherine A. Fitzgerald

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Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus, Lukas Bossaller, Vijay A. K. Rathinam, Ramon Bonegio, Ping-I Chang, Patricia Busto, Adam R. Wespiser, Daniel R. Caffrey, Quan-Zhen Li, Chandra Mohan, Katherine A. Fitzgerald, Eicke Latz, and Ann Marshak-Rothstein

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Monoclonal antibody treatments for rheumatoid arthritis, Lukas Bossaller and Achim Rothe

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Innate sensing of chitin and chitosan, Chelsea L. Bueter, Charles A. Specht, and Stuart M. Levitz

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Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy, Rachel Buglione-Corbett, Kimberly Lea Pouliot, Robyn Lynn Marty-Roix, Kim West, Shixia Wang, Egil Lien, and Shan Lu

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A long noncoding RNA mediates both activation and repression of immune response genes, Susan Carpenter, Daniel Aiello, Maninjay K. Atianand, Emiliano P. Ricci, Pallavi Gandhi, Lisa L. Hall, Meg Byron, Brian G. Monks, Meabh Henry-Bezy, Jeanne B. Lawrence, Luke A. J. O'Neill, Melissa J. Moore, Daniel R. Caffrey, and Katherine A. Fitzgerald

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Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-gamma responses before antiretroviral therapy but not higher T-cell responses during therapy, Christina C. Chang, Andrew Lim, Saleha Omarjee, Stuart M. Levitz, Bernadett I. Gosnell, Tim Spelman, Julian H. Elliott, William H. Carr, Mohamed-Yunus S. Moosa, Thumbi Ndung'u, Sharon R. Lewin, and Martyn A. French

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A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design, Yuxin Chen, Michael Vaine, Aaron Wallace, Dong Han, Shengqin Wan, Michael S. Seaman, David C. Montefiori, Shixia Wang, and Shan Lu

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Novel strategies to enhance vaccine immunity against coccidioidomycosis, Garry T. Cole, Chiung-Yu Hung, Sam D. Sanderson, Brady J. Hurtgen, Marcel Wuthrich, Bruce S. Klein, George S. Deepe, Gary R. Ostroff, and Stuart M. Levitz

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Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid, Joseph E. Conlon, Dara Burdette, Shrutie Sharma, Numana Bhat, Mikayla R. Thompson, Zhaozhao Jiang, Vijay A. K. Rathinam, Brian G. Monks, Tengchuan Jin, T. Sam Xiao, Stefanie N. Vogel, Russell E. Vance, and Katherine A. Fitzgerald

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Human papillomavirus E7 induces rereplication in response to DNA damage, Xueli Fan, Yingwang Liu, Susan Ann Heilman, and Jason J. Chen

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East North Central region has the highest prevalence of vancomycin-resistant Enterococcus faecalis in the United States, Sumanth Gandra, Nikolay Braykov, and Ramanan Laxminarayan

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DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus, Anna Gil, Siyuan Shen, Scott Coley, Laura Gibson, Don J. Diamond, Shixia Wang, and Shan Lu

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Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection, Sunita Gulati, Bo Zheng, George W. Reed, Xiaohong Su, Andrew D. Cox, Frank St. Michael, Jacek Stupak, Lisa A. Lewis, Sanjay Ram, and Peter A. Rice

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C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness, John Patrick Haran, Francesca Lynn Beaudoin, Selim Suner, and Shan Lu

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Cytokine markers as predictors of type of respiratory infection in patients during the influenza season, John Patrick Haran, Rachel Buglione-Corbett, and Shan Lu

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Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus, Gabriel L. Hendricks, Kim L. Weirich, Karthik Viswanathan, Jing Li, Zachary H. Shriver, Joseph Ashour, Hidde L. Ploegh, Evelyn A. Kurt-Jones, Deborah K. Fygenson, Robert W. Finberg, James C. Comolli, and Jennifer P. Wang

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation, John J. Kaminski III, Stefan A. Schattgen, TeChen Tzeng, Christian Bode, Dennis M. Klinman, and Katherine A. Fitzgerald

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Factor H-Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis, Lisa A. Lewis, David M. Vu, Shreekant Vasudhev, Jutamas Shaughnessy, Dan M. Granoff, and Sanjay Ram

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Breastfeeding During Early Infancy is Associated with a Lower Incidence of Febrile Illnesses, Daniel H. Libraty, Rosario Z. Capeding, Anamae Obcena, Job D. Brion, and Veronica Tallo

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Breastfeeding During Early Infancy is Associated with Higher Weight-Based World Health Organization Anthropometry, Daniel H. Libraty, Rosario Z. Capeding, Anamae Obcena, Job D. Brion, and Veronica Tallo

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Toll-like receptor induced pro-interleukin-1beta and interleukin-6 in monocytes are lower in healthy infants compared to adults, Daniel H. Libraty, Lei Zhang, Marcia Woda, Luz P. Acosta, Anamae Obcena, Job D. Brion, and Rosario Z. Capeding

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Quality measures for critically ill patients: where does ventilator-associated condition fit in, Craig M. Lilly and Richard T. Ellison III

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Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice, Dora Lippai, Shashi Bala, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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The role of MyD88 signaling in heterosubtypic influenza A virus infections, Rachel F. Madera and Daniel H. Libraty

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The genome of Anopheles darlingi, the main neotropical malaria vector, Osvaldo Marinotti, Adam R. Wespiser, Daniel R. Caffrey, Douglas T. Golenbock, and Neal S. Silverman

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(De-) oiling inflammasomes, Robyn Lynn Marty-Roix and Egil Lien

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Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways, Mariane B. Melo, Quynh P. Nguyen, Cynthia Cordeiro, Musa A. Hassan, Ninghan Yang, Renee McKell, Emily E. Rosowski, Lindsay Julien, Vincent Butty, Marie-Laure Darde, Daniel Ajzenberg, Katherine A. Fitzgerald, Lucy H. Young, and Jeroen P. J. Saeij

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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta, Bibhuti B. Mishra, Vijay A. K. Rathinam, Gregory W. Martens, Amanda J. Martinot, Hardy Kornfeld, Katherine A. Fitzgerald, and Christopher M. Sassetti

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Telomere length dynamics in human memory T cells specific for viruses causing acute or latent infections, Joel M. O'Bryan, Marcia Woda, Mary Dawn T. Co, Anuja Mathew, and Alan Rothman

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Dengue virus type 2 modulates endothelial barrier function through CD73, Chinmay Patkar, Krisanthi Giaya, and Daniel H. Libraty

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo

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Effect of Race/Ethnicity and Socioeconomic Status on Pandemic H1N1-Related Outcomes in Massachusetts, Hilary Placzek and Lawrence C. Madoff

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Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection, Nicholas Renzette, Laura L. Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, and Timothy F. Kowalik

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Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld

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Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity, Florentina Rus, Thomas Flatt, Mei Tong, Kamna Aggarwal, Kendi Okuda, Anni Kleino, Elisabeth Yates, Marc Tatar, and Neal S. Silverman

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UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major, Bruno Luiz Fonseca Schamber-Reis, Patricia M. Petritus, Braulia C. Caetano, Espiridion R. Martinez, Kendi Okuda, Douglas T. Golenbock, Phillip Scott, and Ricardo T. Gazzinelli

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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Epigenetic Modifications Induced by Blimp-1 Regulate CD8(+) T Cell Memory Progression during Acute Virus Infection, Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, and Leslie J. Berg

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Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1beta response and host resistance to Trypanosoma cruzi infection, Grace Kelly Silva, Renata Sesti Costa, Tatiana Nunes Silveira, Braulia C. Caetano, Catarina Veltrini Horta, Fredy Roberto Gutierrez-Salazar, Paulo Marcos da Matta Guedes, Warrison A. Andrade, Mariana De Niz, Ricardo T. Gazzinelli, Dario Simoes Zamboni, and Joao Santana Silva

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RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA, Cherilyn M. Sirois, Tengchuan Jin, Allison L. Miller, Damien Bertheloot, Hirotaka Nakamura, Gabor Horvath, Abubakar Mian, Jiansheng Jiang, Jacob Schrum, Lukas Bossaller, Karin Pelka, Natalio Garbi, Yambasu Brewah, Jane Tian, ChewShun Chang, Partha S. Chowdhury, Gary P. Sims, Roland Kolbeck, Anthony J. Coyle, Alison A. Humbles, T. Sam Xiao, and Eicke Latz

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Cross-reactive human B cell and T cell epitopes between influenza A and B viruses, Masanori Terajima, Jenny Aurielle B. Babon, Mary Dawn T. Co, and Francis A. Ennis

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The N-terminus of vaccinia virus host range protein C7L is essential for function, Masanori Terajima, Stina L. Urban, and Anita M. Leporati

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Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, Christine Vaine, Milan K. Patel, Jintao Zhu, Eunji Lee, Robert W. Finberg, Ryan C. Hayward, and Evelyn A. Kurt-Jones

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Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien

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Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1), Aaron Wallace, Kim West, Alan L. Rothman, Francis A. Ennis, Shan Lu, and Shixia Wang

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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins, Donghai Wang, Susanne Hoing, Heide Christine Patterson, Umtul M. Ahmad, Vijay A. K. Rathinam, Klaus Rajewsky, Katherine A. Fitzgerald, and Douglas T. Golenbock

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DNA immunization, Shixia Wang and Shan Lu

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Dermatophagoides pteronyssinus Major Allergen 1 Activates the Innate Immune Response of the Fruit Fly Drosophila melanogaster, Christine Warmbold, Karin Uliczka, Florentina Rus, Roland Suck, Arnd Petersen, Neal S. Silverman, Artur J. Ulmer, Holger Heine, and Thomas Roeder

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CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans, Liusong Yin, J. Mauricio Calvo-Calle, John Cruz Jr., Frances K. Newman, Sharon E. Frey, Francis A. Ennis, and Lawrence J. Stern

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Potent monoclonal antibodies against Clostridium difficile toxin A elicited by DNA immunization, Chunhua Zhang, Ke Jin, Yanling Xiao, Ying Cheng, Zuhu Huang, Shixia Wang, and Shan Lu

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Malaria and other Vector-Borne Illnesses, Iva Zivna and Richard T. Ellison III

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Severe Community-Acquired Respiratory Viral Infections, Iva Zivna and Richard T. Ellison III

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Toxin-Mediated Illnesses (Toxic Shock Syndrome, Tetanus, and Botulism), Iva Zivna and Richard T. Ellison III

Publications from 2012

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Cutting Edge: FAS (CD95) mediates noncanonical IL-1beta and IL-18 maturation via caspase-8 in an RIP3-independent manner, Lukas Bossaller, Ping-I Chang, Christian Schmidt-Lauber, Sandhya Ganesan, William J. Kaiser, Vijay A. K. Rathinam, Edward S. Mocarski, Deepa Subramanian, Douglas R. Green, Neal S. Silverman, Katherine A. Fitzgerald, Ann Marshak-Rothstein, and Eicke Latz

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Bacterial effectors: learning on the fly, Laurent Boyer, Nicholas Paul Paquette, Neal S. Silverman, and Lynda M. Stuart

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Immunology. Select inflammasome assembly, Daniel R. Caffrey and Katherine A. Fitzgerald

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Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome, Caroline M. Connor, Aslihan Dincer, Juerg R. Straubhaar, Janina R. Galler, Isaac B. Houston, and Schahram Akbarian

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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1beta and neuronal toxicity, Iva Hafner-Bratkovic, Mojca Bencina, Katherine A. Fitzgerald, Douglas T. Golenbock, and Roman Jerala

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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING, Christian K. Holm, Soren B. Jensen, Martin R. Jakobsen, Natalia Cheshenko, Kristy A. Horan, Hanne B. Moeller, Regina Gonzalez-Dosal, Simon B. Rasmussen, Maria H. Christensen, Timur O. Yarovinsky, Frazer J. Rixon, Betsy C. Herold, Katherine A. Fitzgerald, and Soren R. Paludan

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation, Haifa H. Jabara, Douglas R. McDonald, Erin Janssen, Michel J. Massaad, Narayanaswamy Ramesh, Arturo Borzutzky, Ingrid Rauter, Halli Benson, Lynda Schneider, Sachin Baxi, Mike Recher, Luigi D. Notarangelo, Rima Wakim, Ghassan Dbaibo, Majed Dasouki, Waleed Al-Herz, Isil Barlan, Safa Baris, Necil Kutukculer, Hans D. Ochs, Alessandro Plebani, Maria Kanariou, Gerard Lefranc, Ismail Reisli, Katherine A. Fitzgerald, Douglas T. Golenbock, John Manis, Sevgi Keles, Reuben Ceja, Talal A. Chatila, and Raif S. Geha

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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor, Tengchuan Jin, Andrew Perry, Jiansheng Jiang, Patrick Smith, James A. Curry, Leonie Unterholzner, Zhaozhao Jiang, Gabor Horvath, Vijay A. K. Rathinam, Ricky W. Johnstone, Veit Hornung, Eicke Latz, Andrew G. Bowie, Katherine A. Fitzgerald, and T. Sam Xiao

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UnZIPping mechanisms of effector-triggered immunity in animals, Anni Kleino and Neal S. Silverman

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Viral infection: an evolving insight into the signal transduction pathways responsible for the innate immune response, Girish J. Kotwal, Steven Hatch, and William L. Marshall

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Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling, Annika Meinander, Christopher Runchel, Tencho Tenev, Li Chen, Chan-Hee Kim, Paulo S. Ribeiro, Meike Broemer, Francois Leulier, Marketa Zvelebil, Neal S. Silverman, and Pascal Meier

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Use of whole plant Artemisia annua L. as an antimalarial therapy, Elfawal Mostafa, Melissa J. Towler, Ricardo T. Gazzinelli, Douglas T. Golenbock, Pamela J. Weathers, and Stephen M. Rich

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation, Ribhu Nayar, Megan E. Enos, Amanda L. Prince, HyunMu Shin, Saskia Hemmers, Jian-kang Jiang, Ulf Klein, Craig J. Thomas, and Leslie J. Berg

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Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling, Nicholas Paul Paquette, Joseph E. Conlon, Charles R. Sweet, Florentina Rus, Lindsay Wilson, Andrea J. Pereira, Charles V. Rosadini, Nadege Goutagny, Alexander N. R. Weber, William S. Lane, Scott A. Shaffer, Stephanie Maniatis, Katherine A. Fitzgerald, Lynda M. Stuart, and Neal S. Silverman

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice, Jan Petrasek, Shashi Bala, Timea Csak, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, So-Yun Min, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice, Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential, Daniel Prantner, Darren J. Perkins, Wendy Lai, Mark S. Williams, Shrutie Sharma, Katherine A. Fitzgerald, and Stefanie N. Vogel

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Defective pro-IL-1beta responses in macrophages from aged mice, Alejandor Ramirez, Vijay A. K. Rathinam, Katherine A. Fitzgerald, Douglas T. Golenbock, and Anuja Mathew

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Regulation of inflammasome signaling, Vijay A. K. Rathinam, Sivapriya Kailasan Vanaja, and Katherine A. Fitzgerald

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria, Vijay A. K. Rathinam, Sivapriya Kailasan Vanaja, Lisa Waggoner, Anna Sokolovska, Christine Becker, Lynda M. Stuart, John M. Leong, and Katherine A. Fitzgerald

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Immune responses in cystic fibrosis: are they intrinsically defective?, Dmitry Ratner and Christian Mueller

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Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathways, Florentina Rus, Kayla Morlock, Neal S. Silverman, Ngoc Pham, Girish J. Kotwal, and William L. Marshall

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TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia, Andrea Scharfe-Nugent, Sinead C. Corr, Susan B. Carpenter, Louise Keogh, Brendan Doyle, Cara Martin, Katherine A. Fitzgerald, Sean Daly, John J. O'Leary, and Luke A. J. O'Neill

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Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction, Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang, Juraj Kabat, Abu-Asab Mones, Katherine A. Fitzgerald, Alan Sher, and John H. Kehrl

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Kenichi Shimada, Timothy R. Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V. Krishnan Ramanujan, Andrea J. Wolf, Laurent Vergnes, David M. Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A. Fitzgerald, David M. Underhill, Terrence Town, and Moshe Arditi

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CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2, Roy J. Soberman, Christopher R. MacKay, Christine A. Vaine, Glennice Bowen Ryan, Anna M. Cerny, Mikayla R. Thompson, Boris Nikolic, Valeria Primo, Peter Christmas, Paul Sheiffele, Lisa Aronov, David M. Knipe, and Evelyn A. Kurt-Jones