This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2012

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential, Daniel Prantner, Darren J. Perkins, Wendy Lai, Mark S. Williams, Shrutie Sharma, Katherine A. Fitzgerald, and Stefanie N. Vogel

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Defective pro-IL-1beta responses in macrophages from aged mice, Alejandor Ramirez, Vijay A. K. Rathinam, Katherine A. Fitzgerald, Douglas T. Golenbock, and Anuja Mathew

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Regulation of inflammasome signaling, Vijay A. K. Rathinam, Sivapriya Kailasan Vanaja, and Katherine A. Fitzgerald

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria, Vijay A. K. Rathinam, Sivapriya Kailasan Vanaja, Lisa Waggoner, Anna Sokolovska, Christine Becker, Lynda M. Stuart, John M. Leong, and Katherine A. Fitzgerald

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Immune responses in cystic fibrosis: are they intrinsically defective?, Dmitry Ratner and Christian Mueller

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The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors, Keith P. Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Aysegul Ozen, Laura M. Deveau, Casey Silver, Hong Cao, Alicia Newton, Christos J. Petropoulos, Wei Huang, and Celia A. Schiffer

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Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathways, Florentina Rus, Kayla Morlock, Neal S. Silverman, Ngoc Pham, Girish J. Kotwal, and William L. Marshall

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TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia, Andrea Scharfe-Nugent, Sinead C. Corr, Susan B. Carpenter, Louise Keogh, Brendan Doyle, Cara Martin, Katherine A. Fitzgerald, Sean Daly, John J. O'Leary, and Luke A. J. O'Neill

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Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction, Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang, Juraj Kabat, Abu-Asab Mones, Katherine A. Fitzgerald, Alan Sher, and John H. Kehrl

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis, Kenichi Shimada, Timothy R. Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V. Krishnan Ramanujan, Andrea J. Wolf, Laurent Vergnes, David M. Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A. Fitzgerald, David M. Underhill, Terrence Town, and Moshe Arditi

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CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2, Roy J. Soberman, Christopher R. MacKay, Christine A. Vaine, Glennice Bowen Ryan, Anna M. Cerny, Mikayla R. Thompson, Boris Nikolic, Valeria Primo, Peter Christmas, Paul Sheiffele, Lisa Aronov, David M. Knipe, and Evelyn A. Kurt-Jones

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Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status, Anon Srikiatkhachorn, Sineewanlaya Wichit, Robert V. Gibbons, Sharone Green, Daniel H. Libraty, Timothy P. Endy, Francis A. Ennis, Siripen Kalayanarooj, and Alan L. Rothman

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Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger

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The NLRP12 Inflammasome Recognizes Yersinia pestis, Gregory I. Vladimer, Dan Weng, Sara W. Montminy Paquette, Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Marie Hjelmseth Aune, Joseph E. Conlon, Joseph J. Burbage, Megan K. Proulx, Qin Liu, George W. Reed, Joan C. Mecsas, Yoichiro Iwakura, John Bertin, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien

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Effect of a Multidisciplinary Team Approach to Eradicate Central Line Associated Blood-Stream Infections (CLABSI), J. Matthias Walz, Richard T. Ellison III, Helen Flaherty, John McIlwaine, Deborah Ann Mack, Kathleen Whyte, Karen Landry, Stephen P. Baker, Stephen O. Heard, and CCOC Research Group

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Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants, Jennifer P. Wang, Lei Zhang, Rachel F. Madera, Marcia Woda, and Daniel H. Libraty

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Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates, Shixia Wang, Michael G. Kishko, Shengqin Wan, Yan Wang, Frank E. Brewster, Glenda E. Gray, Avye Violari, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and Shan Lu

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Type 1 interferons and antiviral CD8 T-cell responses, Raymond M. Welsh, Kapil Bahl, Heather D. Marshall, and Stina L. Urban

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CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone, James L. Young, Alfonso Mora, Anna M. Cerny, Michael P. Czech, Bruce A. Woda, Evelyn A. Kurt-Jones, Robert W. Finberg, and Silvia Corvera

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Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection, Shenghua Zhou, Anna M. Cerny, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Robert W. Finberg

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PU.1 Is Essential for CD11c Expression in CD8(+)/CD8(-) Lymphoid and Monocyte-Derived Dendritic Cells during GM-CSF or FLT3L-Induced Differentiation, Xue-Jun Zhu, Zhongfa Yang, Yaoyu Chen, Junling Wang, and Alan G. Rosmarin

Publications from 2011

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Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice, Jennifer L. Ather, Karina Ckless, Rebecca Martin, Kathryn L. Foley, Benjamin T. Suratt, Jonathan E. Boyson, Katherine A. Fitzgerald, Richard A. Flavell, Stephanie C. Eisenbarth, and Matthew E. Poynter

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Low Level Bacterial Endotoxin Activates Two Distinct Signaling Pathways in Human peripheral blood mononuclear cells, Andra L. Blomkalns, Lynn L. Stoll, Wassim Shaheen, Sara A. Romig-Martin, Eric W. Dickson, Neal L. Weintraub, and Gerene M. Denning

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Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway, Laurent Boyer, Lorin Magoc, Stephanie Dejardin, Michael Cappillino, Nicholas Paul Paquette, Charlotte Hinault, Guillaume M. Charriere, W. K. Eddie Ip, Shannon Fracchia, Elizabeth Hennessy, Deniz Erturk Hasdemir, Jean-Marc Reichhart, Neal S. Silverman, Adam Lucy-Hulbert, and Lynda M. Stuart

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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation, YoungSik Cho, Thomas McQuade, Haibing Zhang, Jianke Zhang, and Francis Ka-Ming Chan

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Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway, Peihong Dai, Hua Cao, Taha Merghoub, Francesca Avogadri, Weiyi Wang, Tanvi Parikh, Chee-Mun Fang, Paula M. Pitha, Katherine A. Fitzgerald, Masmudur M. Rahman, Grant McFadden, Xiaoyu Hu, Alan N. Houghton, Stewart Shuman, and Liang Deng

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TRAIL and DcR1 expressions are differentially regulated in the pancreatic islets of STZ- versus CY-applied NOD mice, Ercument Dirice, Sevin Kahraman, Gulsum Ozlem Elpek, Cigdem Aydin, Mustafa Kemal Balci, Abdulkadir Omer, Salih Sanlioglue, and Ahter Dilsad Sanlioglue

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An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus, Xiaofei E., Mary Theresa Pickering, Michelle E. Debatis, Jonathan Patrick Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, and Timothy F. Kowalik

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The interferon inducible gene: Viperin, Katherine A. Fitzgerald

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Conversion of tumors into autologous vaccines by intratumoral injection of alpha-Gal glycolipids that induce anti-Gal/alpha-Gal epitope interaction, Uri Galili

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NF-kappaB/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster, Sandhya Ganesan, Kamna Aggarwal, Nicholas Paul Paquette, and Neal S. Silverman

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Lessons from the Field: Parasite DNA Drives the Innate Immune Response to Malaria (it's not just the caiparinhas), Douglas Golenbock

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Autophagy controls IL-1{beta} secretion by targeting pro-IL-1{beta} for degradation, James Harris, Michelle L. Hartman, Caitrionna Roche, Shijuan G. Zeng, Amy O'Shea, Fiona Sharp, Eimear M. Lambe, Emma M. Creagh, Douglas T. Golenbock, Jurg Tschopp, Hardy Kornfeld, Katherine A. Fitzgerald, and Ed C. Lavelle

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Interactions between naive and infected macrophages reduce Mycobacterium tuberculosis viability, Michelle L. Hartman and Hardy Kornfeld

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Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study, Susan S. Huang, Rupak Datta, Sheryl L. Rifas-Shiman, Ken P. Kleinman, Hilary Placzek, Julie Lankiewicz, and Richard Platt

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Mice completely lacking immunoproteasomes show major changes in antigen presentation, Eleanor Z. Kincaid, Jenny Wun-Yue Che, Ian York, Hernando Escobar, Eduardo Reyes-Vargas, Julio C. Delgado, Raymond M. Welsh, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, and Kenneth L. Rock

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Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga

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Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages, Jinhee Lee, Teresa Repasy, Kadamba Papavinasasundaram, Christopher M. Sassetti, and Hardy Kornfeld

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Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection, Jun Li, Yaping Han, Ke Jin, Yufeng Wan, Shixia Wang, Bo Liu, Yuan Liu, Shan Lu, and Zuhu Huang

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The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses, Rachel F. Madera, Jennifer P. Wang, and Daniel H. Libraty

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A new approach to monitoring dengue activity, Lawrence C. Madoff, David N. Fisman, and Taha Kass-Hout

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Cytotoxic CD4 T cells in antiviral immunity, Nikki B. Marshall and Susan L. Swain

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A natural loss-of-function mutation of MyD88 disrupts its ability to form Myddosomes, Kamalpreet Nagpal, Theo S. Plantinga, Cherilyn M. Sirois, Brian G. Monks, Eicke Latz, Mihai G. Netea, and Douglas T. Golenbock

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A.K. Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C. lam, Joshua A. Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim, Katherine A. Fitzgerald, Stefan W. Ryter, and Augustine M. K. Choi

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Recognition of herpesviruses by the innate immune system, Soren R. Paludan, Andrew G. Bowie, Kristy A. Horan, and Katherine A. Fitzgerald

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Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fc{gamma} Receptor (Fc{gamma}RIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein, Ravichandran Panchanathan, Hui Shen, Xin Duan, Vijay A. K. Rathinam, Loren D. Erickson, Katherine A. Fitzgerald, and Divaker Choubey

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Inhibition of TLR8- and TLR4-induced Type I IFN Induction by Alcohol is Different from its effects on inflammatory cytokine production in monocytes, Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract, Dane Parker, Francis J. Martin, Grace Soong, Bryan S. Harfenist, Jorge L. Aguilar, Adam J. Ratner, Katherine A. Fitzgerald, Christian Schindler, and Alice Prince

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Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells, Jan Petrasek, Angela Dolganiuc, Timea Csak, Bharath D. Nath, Istvan Hritz, Karen Kodys, Donna Catalano, Evelyn A. Kurt-Jones, Pranoti Mandrekar, and Gyongyi Szabo

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Identification of Influenza Cases During the H1N1 Pandemic in Massachusetts Using Population-Based Hospital Discharge Data, Hilary Placzek and Lawrence C. Madoff

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Innate immune sensing of DNA viruses, Vijay A.K. Rathinam and Katherine A. Fitzgerald

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Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

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The PYHIN protein family as mediators of host defenses, Stefan A. Schattgen and Katherine A. Fitzgerald

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Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure, Mark E. Sharkey, Dunja Z. Babic, Thomas C. Greenough, Roy Gulick, Daniel R. Kuritzkes, and Mario Stevenson

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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome, Shrutie Sharma, Rosane B. DeOliveira, Parisa Kalantari, Peggy Parroche, Nadege Goutagny, Zhaozhao Jiang, Jennie Chan, Daniella C. Bartholomeu, Fanny N. Lauw, J. Perry Hall, Glen N. Barber, Ricardo T. Gazzinelli, Katherine A. Fitzgerald, and Douglas T. Golenbock

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Innate immune sensing of DNA, Shrutie Sharma and Katherine A. Fitzgerald

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Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis, Sergey A. Shiryaev, Piotr Cieplak, Alexander E. Aleshin, Qing Sun, Wenhong Zhu, Khatereh Motamedchaboki, Alexander Sloutsky, and Alex Y. Strongin

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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-(beta) and RANTES production, Jakub Siednienko, Thusitha Gajanayake, Katherine A. Fitzgerald, Paul Moynagh, and Sinead M. Miggin

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Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection, Barbara S. Stewart, Valerie L. Demarest, Susan J. Wong, Sharone Green, and Kristen A. Bernard

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Pattern recognition receptors and the innate immune response to viral infection, Mikayla R. Thompson, John J. Kaminski III, Evelyn A. Kurt-Jones, and Katherine A. Fitzgerald

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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans, Jeffrey Tomalka, Sandhya Ganesan, Elaheh Azodi, Krupen Patel, Parth Majmudar, Brian A. Hall, Katherine A. Fitzgerald, and Amy G. Hise

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Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans, Jennifer P. Wang, Chrono K. Lee, Ali Akalin, Robert W. Finberg, and Stuart M. Levitz

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Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM, Lijian Wang, Estela Trebicka, Ying Fu, Lisa Waggoner, Shizuo Akira, Katherine A. Fitzgerald, Jonathan C. Kagan, and Bobby J. Cherayil

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ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae, Sandy M. S. Wong, Frank St. Michael, Andrew Cox, Sanjay Ram, and Brian J. Akerley

Publications from 2010

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IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway, Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, and Paula M. Pitha

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Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression, Angika Basant, Mayuri Rege, Shobhona Sharma, and Haripalsingh M. Sonawat

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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome, Christian Bauer, Peter Duewell, Christine Mayer, Hans Anton Lehr, Katherine A. Fitzgerald, Marc Dauer, Jurg Tschopp, Stefan Endres, Eicke Latz, and Max Schnurr

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Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters, Guillaume M. Charriere, Wk Eddie Ip, Stephanie Dejardin, Laurent Boyer, Anna Sokolovska, Michael P. Cappillino, Bobby J. Cherayil, Daniel K. Podolsky, Koichi S. Kobayashi, Neal S. Silverman, Adam Lacy-Hulbert, and Lynda M. Stuart

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz

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NLR-containing inflammasomes: central mediators of host defense and inflammation, Katherine A. Fitzgerald

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Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein, Nadege Goutagny, Zhaozhao Jiang, Jane Tian, Peggy Parroche, Jeanne Schickli, Brian G. Monks, Nancy Ulbrandt, Hong Ji, Peter A. Kiener, Anthony J. Coyle, and Katherine A. Fitzgerald

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Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling, Pearl Gray, Kathrin S. Michelsen, Cherilyn M. Sirois, Emily Lowe, Kenichi Shimada, Timothy R. Crother, Shuang Chen, Constantinos Brikos, Yonca Bulut, Eicke Latz, David Underhill, and Moshe Arditi

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Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded beta-Glucan Particles, Habin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Automated Detection of Infectious Disease Outbreaks in Hospitals: A Retrospective Cohort Study, Susan S. Huang, Deborah S. Yokoe, John Stelling, Hilary Placzek, Martin Kulldorff, Ken Kleinman, Thomas F. O'Brien, Michael S. Calderwood, Johanna Vostok, Julie Dunn, and Richard Platt

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Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome, Sarah Kim, Franz G. Bauernfeind, Andrea Ablasser, Gunther Hartmann, Katherine A. Fitzgerald, Eicke Latz, and Veit Hornung

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Uric acid promotes an acute inflammatory response to sterile cell death in mice, Hajime Kono, Chun-Jen Chen, Fernando Ontiveros, and Kenneth L. Rock

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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts, Oliver Kumpf, Evangelos J. Giamarellos-Bourboulis, Alexander Koch, Lutz Hamann, Maria Mouktaroudi, Djin-Ye Oh, Eicke Latz, Eva Lorenz, David A. Schwartz, Bart Ferwerda, Christina Routsi, Chryssanthi Skalioti, Bart-Jan Kullberg, Jos W. M. van der Meer, Peter M. Schlag, Mihai G. Netea, Kai Zacharowski, and Ralf R. Schumann

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Innate recognition of fungal cell walls, Stuart M. Levitz

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The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement, Lisa A. Lewis, Jutamas Ngampasutadol, Ruth Wallace, Jane E. A. Reid, Ulrich Vogel, and Sanjay Ram

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Detecting microRNA activity from gene expression data, Stephen F. Madden, Susan B. Carpenter, Ian B. Jeffery, Harry Bjorkbacka, Katherine A. Fitzgerald, Luke A. J. O'Neill, and Desmond G. Higgins

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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality, Erica Marchlik, Paresh Thakker, Thaddeus Carlson, Zhaozhao Jiang, Mark Ryan, Suzana Marusic, Nadege Goutagny, Wen Kuang, G. Roger Askew, Victoria Roberts, Stephen Benoit, Tianhui Zhou, Vincent Ling, Richard Pfeifer, Nancy Stedman, Katherine A. Fitzgerald, Lih-Ling Lin, and J. Perry Hall

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions, Heather D. Marshall, Amanda L. Prince, Leslie J. Berg, and Raymond M. Welsh

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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4, Edel A. McNeela, Aine Burke, Daniel R. Neill, Cathy Baxter, Vitor E. Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M. McLoughlin, Andres Mori, Barry Moran, Katherine A. Fitzgerald, Jurg Tschopp, Virginie Petrilli, Peter W. Andrew, Aras Kadioglu, and Ed C. Lavelle

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Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e., Christian Mueller, Allison M. Keeler, Sofia Braag, Timothy Menz, Qiushi Tang, and Terence R. Flotte

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Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment, Kavitha Narayan and Joonso Kang

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Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3), Thuy Thanh Nguyen, Ingvild B. Johnsen, Catherine F. Knetter, Finn Drablos, Katherine A. Fitzgerald, Egil Lien, and Marit W. Anthonsen

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NOD1 and NOD2 mediate sensing of periodontal pathogens, T. Okugawa, Takashi Kaneko, A. Yoshimura, Neal S. Silverman, and Y. Hara

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Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus, Ravichandran Panchanathan, Xin Dua, Hui Shen, Vijay A.K. Rathinam, Loren D. Erickson, Katherine A. Fitzgerald, and Divaker Choubey

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Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-κB Signaling, Nicholas Paul Paquette, Meike Broemer, Kamna Aggarwal, Li Chen, Marie Husson, Deniz Erturk Hasdemir, Jean-Marc Reichhart, Pascal Meier, and Neal S. Silverman

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The use of immunization registry-based data in vaccine effectiveness studies, Hilary Placzek and Lawrence C. Madoff

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Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators, James A. Potts, Robert V. Gibbons, Alan L. Rothman, Anon Srikiatkhachorn, Stephen J. Thomas, Pra-On Supradish, Stephenie C. Lemon, Daniel H. Libraty, Sharone Green, and Siripen Kalayanarooj

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Maturation-dependent licensing of naive T cells for rapid TNF production, Bhavana Priyadharshini, Raymond M. Welsh, Dale L. Greiner, Rachel M. Gerstein, and Michael A. Brehm

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Inflammasomes and anti-viral immunity, Vijay A.K. Rathinam and Katherine A. Fitzgerald

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald

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Catenin' on to nucleic acid sensing, Vijay A.K. Rathinam, Shrutie Sharma, and Katherine A. Fitzgerald

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Viral defense: it takes two MAVS to Tango, Shrutie Sharma and Katherine A. Fitzgerald

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern