This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2015

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The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever, Daniel H. Libraty, Pengyan Wang, Zhiru Guo, Venelle Bigcas, Job D. Brion, and Rosario Z. Capeding

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Influenza virus infections in the tropics during the first year of life, Daniel H. Libraty, Lei Zhang, Mercydina Caponpon, and Rosario Z. Capeding

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Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps, Flavio V. Loures, Marc Rohm, Chrono K. Lee, Evelyn Santos, Jennifer P. Wang, Charles A. Specht, Vera L.G. Calich, Constantin F. Urban, and Stuart M. Levitz

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Accidental Needlestick Exposures linked to the Administration of Local Anesthesia by Healthcare Workers, Hannah Martin, Christina Hermos, Constance M. Barysauskas, Susan L. Bradbury, Susan Sullivan, and Richard T. Ellison III

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The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women, Ryan McClure, Kathleen Nudel, Paola Massari, Brian Tjaden, Xiaohong Su, Peter A. Rice, and Caroline A. Genco

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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling, Nadra J. Nilsen, Gregory I. Vladimer, Jorgen Stenvik, M. Pontus A. Orning, Maria V. Zeid-Kilani, Marit Bugge, Bjarte Bergstroem, Joseph E. Conlon, Harald Husebye, Amy G. Hise, Katherine A. Fitzgerald, Terje Espevik, and Egil Lien

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Small RNA Regulation of the Innate Immune Response: A Role for Dicer in the Control of Viral Production and Sensing of Nucleic Acids: A Dissertation, Ryan J. Nistler

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A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice, Javier Gordon Ogembo, Matthew R. Muraswki, Lori McGinnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W. Finberg, Trudy G. Morrison, and Joyce D. Fingeroth

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Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis, Anil A. Panackal, Stuart M. Levitz, Bibi Bielekova, and Peter R. Williamson

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An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual, Sudesh Pawaria, Krishna L. Moody, Patricia Busto, Kerstin Nundel, Rebecca Baum, Shrutie Sharma, Ellen M. Gravallese, Katherine A. Fitzgerald, and Ann Marshak-Rothstein

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A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy, Isabela Resende Pereira, Glaucia Vilar-Pereira, Virginia Marques, Andrea Alice da Silva, Braulia Caetano, Otacilio Cruz Moreira, Alexandre Vieira Machado, Oscar Bruna-Romero, Mauricio Martins Rodrigues, Ricardo T. Gazzinelli, and Joseli Lannes-Vieira

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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Banishree Saha, Abhishek Satishchandran, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia, Megan K. Proulx, Samantha G. Palace, Sumanth Gandra, Brenda Torres, Susan Weir, Tracy Stiles, Richard T. Ellison III, and Jon D. Goguen

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Limits and patterns of cytomegalovirus genomic diversity in humans, Nicholas Renzette, Cornelia Pokalyuk, Laura Gibson, Bornali Bhattacharjee, Mark R. Schleiss, Klaus Hamprecht, Aparecida Y. Yamamoto, Marisa M. Mussi-Pinhata, William J. Britt, Jeffrey D. Jensen, and Timothy F. Kowalik

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Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress, Zhiji Ren and Victor R. Ambros

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Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors, Soroush T. Sarvestani, H. James Stunden, Mark A. Behlke, Samuel C. Forster, Claire E. McCoy, Michelle D. Tate, Jonathan Ferrand, Kim A. Lennox, Eicke Latz, Bryan R. G. Williams, and Michael P. Gantier

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Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts, Charles A. Specht, Chrono K. Lee, Haibin Huang, Donald J. Tipper, Zu T. Shen, Jennifer K. Lodge, John D. Leszyk, Gary R. Ostroff, and Stuart M. Levitz

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Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection, Chenglong Sun, Stefan A. Schattgen, Prapaporn Pisitkun, Joan P. Jorgensen, Adam T. Hilterbrand, Lucas J. Wang, John A. West, Kathrine Hansen, Kristy A. Horan, Martin R. Jakobsen, Peter O'Hare, Heiko Adler, Ren Sun, Hidde L. Ploegh, Blossom Damania, Jason W. Upton, Katherine A. Fitzgerald, and Soren R. Paludan

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Identification of Aim2 as a sensor for DNA vaccines, John Suschak, Shixia Wang, Katherine A. Fitzgerald, and Shan Lu

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High Antibody-Dependent Cellular Cytotoxicity Antibody Titers to H5N1 and H7N9 Avian Influenza A Viruses in Healthy US Adults and Older Children, Masanori Terajima, Mary Dawn T. Co, John Cruz, and Francis A. Ennis

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Mechanisms of inflammasome activation: recent advances and novel insights, Sivapriya K. Vanaja, Vijay A. K. Rathinam, and Katherine A. Fitzgerald

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HLA Class I Supertype Associations With Clinical Outcome of Secondary Dengue Virus Infections in Ethnic Thais, Sasijit Vejbaesya, Rungrot Thongpradit, Siripen Kalayanarooj, Komon Luangtrakool, Panpimon Luangtrakool, Robert V. Gibbons, Duangporn Srinak, Somporn Ngammthaworn, Kusuma Apisawes, In-Kyu Yoon, Stephen J. Thomas, Richard G. Jarman, Anon Srikiatkhachorn, Sharone Green, Dasnayanee Chandanayingyong, Sangshin Park, Jennifer Friedman, Alan L. Rothman, and Henry A.F. Stephens

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Weekly Treatment of 2-Hydroxypropyl-beta-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice, Sofie M.A. Walenbergh, Tom Houben, Tim Hendrikx, Mike L.J. Jeurissen, Patrick J. van Gorp, Nathalie Vaes, Steven W.M. Olde Damink, Fons Verheyen, Ger H. Koek, Dieter Lutjohann, Alena Grebe, Eicke Latz, and Ronit Shiri-Sverdlov

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The bundle "plus": the effect of a multidisciplinary team approach to eradicate central line-associated bloodstream infections, J. Matthias Walz, Richard T. Ellison III, Deborah A. Mack, Helen M. Flaherty, John K. McIlwaine, Kathleen G. Whyte, Karen E. Landry, Stephen P. Baker, and Stephen O. Heard

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Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection, Darin L. Wiesner, Charles A. Specht, Chrono K. Lee, Kyle D. Smith, Liliane Mukaremera, S. Thera Lee, Chun G. Lee, Jack A. Elias, Judith N. Nielsen, David R. Boulware, Paul R. Bohjanen, Marc K. Jenkins, Stuart M. Levitz, and Kirsten Nielsen

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High rate of subclinical chikungunya virus infection and association of neutralizing antibody with protection in a prospective cohort in the Philippines, In-Kyu Yoon, Maria Theresa Alera, Catherine B. Lago, Ilya A. Tac-An, Daisy Villa, Stefan Fernandez, Butsaya Thaisomboonsuk, Chonticha Klungthong, Jens W. Levy, John Mark Velasco, Vito G. Roque Jr., Henrik Salje, Louis R. Macareo, Laura L. Hermann, Ananda Nisalak, and Anon Srikiatkhachorn

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Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment, Konstantin B. Zeldovich, Ping Liu, Nicholas Renzette, Matthieu Foll, Serena T. Pham, Sergey V. Venev, Glen R. Gallagher, Daniel N. Bolon, Evelyn A. Kurt-Jones, Jeffrey D. Jensen, Daniel R. Caffrey, Celia A. Schiffer, Timothy F. Kowalik, Jennifer P. Wang, and Robert W. Finberg

Publications from 2014

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Induction of IL-12 production in human peripheral monocytes by Trypanosoma cruzi Is mediated by glycosylphosphatidylinositol-anchored mucin-like glycoproteins and potentiated by IFN- gamma and CD40-CD40L interactions, Lucia Cristina Abel Jamli, Ludmila Rodrigues Ferreira Pinto, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo T. Gazzinelli, Luiz Vicente Rizzo, and Edecio Cunha-Neto

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The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria, Lis R.V. Antonelli, Fabiana M.S. Leoratti, Pedro A.C. Costa, Bruno C. Rocha, Suelen Q. Diniz, Mauro S. Tada, Dhelio B. Pereira, Andrea Teixeira-Carvalho, Douglas T. Golenbock, Ricardo Goncalves, and Ricardo T. Gazzinelli

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Genetic vaccination against experimental infection with myotropic parasite strains of Trypanosoma cruzi, Adriano Fernando Araujo, Gabriel de Oliveira, Juliana Fraga Vasconcelos, Jonatan Ersching, Mariana Ribeiro Dominguez, Jose Ronnie Vasconcelos, Alexandre Vieira Machado, Ricardo T. Gazzinelli, Oscar Bruna-Romero, Milena Botelho Soares, and Mauricio Martins Rodrigues

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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection, Marco A. Ataide, Warrison A. Andrade, Dario S. Zamboni, Donghai Wang, Maria do Carmo Souza, Bernardo S. Franklin, Samir Elian, Flaviano S. Martins, Dhelio Pereira, George W. Reed, Katherine A. Fitzgerald, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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Long non-coding RNAs and control of gene expression in the immune system, Maninjay K. Atianand and Katherine A. Fitzgerald

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Protective immunity and safety of a genetically modified influenza virus vaccine, Rafael Polidoro Alves Barbosa, Ana Paula Carneiro Salgado, Cristiana Couto Garcia, Bruno Galvao Filho, Ana Paula de Faria Paula de Faria Goncalves, Braulio Henrique Freire Lima, Gabriel Augusto Oliveira Lopes, Milene Alvarenga Rachid, Andiara Cristina Cardoso Peixoto, Danilo Bretas de Oliveira, Marco Antonio Ataide, Carla Aparecida Zirke, Tatiane Marques Cotrim, Erica Azevedo Costa, Gabriel Magno de Freitas Almeida, Remo Castro Russo, Ricardo T. Gazzinelli, and Alexandre de Magalhaes Vieira Machado

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Recognition of cytosolic DNA by cGAS and other STING-dependent sensors, Numana Bhat and Katherine A. Fitzgerald

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The spatial dynamics of dengue virus in Kamphaeng Phet, Thailand, Piraya Bhoomiboonchoo, Robert V. Gibbons, Angkana Huang, In-Kyu Yoon, Darunee Buddhari, Ananda Nisalak, Natkamol Chansatiporn, Mathuros Thipayamongkolgul, Siripen Kalanarooj, Timothy Endy, Alan L. Rothman, Anon Srikiatkhachorn, Sharone Green, Mammen P. Mammen, Derek A. Cummings, and Henrik Salje

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Potential bloodborne pathogen exposure from occult mattress damage, Susan L. Bradbury, Deborah Ann Mack, Terri Crofts, and Richard T. Ellison III

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Immunity in Drosophila melanogaster--from microbial recognition to whole-organism physiology, Nicolas Buchon, Neal S. Silverman, and Sara Cherry

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Dengue virus neutralizing antibody levels associated with protection from infection in Thai cluster studies, Darunee Buddhari, Jared Aldstadt, Timothy P. Endy, Anon Srikiatkhachorn, Butsaya Thaisomboonsuk, Chonticha Klungthong, Ananda Nisalak, Benjawan Khuntirat, Richard G. Jarman, Stefan Fernandez, Stephen J. Thomas, Thomas W. Scott, Alan L. Rothman, and In-Kyu Yoon

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Spectrum and mechanisms of inflammasome activation by chitosan, Chelsea L. Bueter, Chrono K. Lee, Jennifer P. Wang, Gary R. Ostroff, Charles A. Specht, and Stuart M. Levitz

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Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring, Sarah E. Canetta, Yuanyuan Bao, Mary Dawn T. Co, Francis A. Ennis, John Cruz, Masanori Terajima, Ling Shen, Christoph Kellendonk, Catherine A. Schaefer, and Alan S. Brown

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Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond, Susan B. Carpenter and Katherine A. Fitzgerald

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Post-transcriptional regulation of gene expression in innate immunity, Susan Carpenter, Emiliano P. Ricci, Blandine C. Mercier, Melissa J. Moore, and Katherine A. Fitzgerald

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Citrobacter rodentium: infection, inflammation and the microbiota, James W. Collins, Kristie M. Keeney, Valerie F. Crepin, Vijay A. K. Rathinam, Katherine A. Fitzgerald, B. Brett Finlay, and Gad Frankel

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Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A(H1N1)pdm09 Influenza in children, Mary Dawn T. Co, Masanori Terajima, Stephen J. Thomas, Richard G. Jarman, Kamonthip Rungrojcharoenkit, Stefan Fernandez, In-Kyu Yoon, Darunee Buddhari, John Cruz, and Francis A. Ennis

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Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis, Timea Csak, Arun Pillai, Michal Ganz, Dora Lippai, Jan Petrasek, Jin-Kyu Park, Karen Kodys, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1beta interferes with mature IL-1beta signaling, Facundo Davaro, Sorcha D. Forde, Mark Garfield, Zhaozhao Jiang, Kristen A. Halmen, Nelsy DePaula Tamburro, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Douglas T. Golenbock, and Donghai Wang

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Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption, Stephane Dissel, Laurent Seugnet, Matthew S. Thimgan, Neal S. Silverman, Veena Angadi, Pamela V. Thacher, Melissa M. Burnham, and Paul J. Shaw

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Genetic rescue of functional senescence in synaptic and behavioral plasticity, Jeffrey M. Donlea, Narendrakumar Ramanan, Neal S. Silverman, and Paul J. Shaw

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Acute Pneumonia, Richard T. Ellison III and Gerald R. Donowitz

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TLR4 activation induces IL-1ss release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung, Suffwan Eltom, Maria G. Belvisi, Liang Yew-Booth, Bilel Dekkak, Sarah A. Maher, Eric D. Dubuis, Victoria Jones, Kate A. Fitzgerald, and Mark A. Birrell

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Rift Valley fever virus infection induces activation of the NLRP3 inflammasome, Megan E. Ermler, Zachary Traylor, Krupen Patel, Stefan A. Schattgen, Sivapriya K. Vanaja, Katherine A. Fitzgerald, and Amy G. Hise

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Long noncoding RNAs in innate and adaptive immunity, Katherine A. Fitzgerald and Daniel R. Caffrey

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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello

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Impact of contact precautions on falls, pressure ulcers and transmission of MRSA and VRE in hospitalized patients, Sumanth Gandra, Constance Barysauskas, Deborah Ann Mack, Bruce A. Barton, Robert W. Finberg, and Richard T. Ellison III

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Modern trends in infection control practices in intensive care units, Sumanth Gandra and Richard T. Ellison III

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Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans, Sandhya Ganesan, Vijay A. K. Rathinam, Lukas Bossaller, Kelly Army, William J. Kaiser, Edward S. Mocarski, Christopher P. Dillon, Douglas R. Green, Tanya N. Mayadas, Stuart M. Levitz, Amy G. Hise, Neal S. Silverman, and Katherine A. Fitzgerald

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Innate sensing of malaria parasites, Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald, and Douglas T. Golenbock

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RNA and beta-hemolysin of Group B streptococcus induce IL-1beta by activating NLRP3 inflammasomes in mouse macrophages, Rahul Gupta, Shubhendu Ghosh, Brian G. Monks, Rosane B. DeOliveira, TeChen Tzeng, Parisa Kalantari, Anubhab Nandy, Bornali Bhattacharjee, Jennie Chan, Fabianno Ferreira, Vijay A.K. Rathinam, Shrutie Sharma, Egil Lien, Neal S. Silverman, Katherine A. Fitzgerald, Arnaud Firon, Patrick Trieu-Cuot, Philipp Henneke, and Douglas T. Golenbock

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SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter, Claudia Gurtler, Michael Carty, Jay Kearney, Stefan A. Schattgen, Aihao Ding, Katherine A. Fitzgerald, and Andrew G. Bowie

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Profiles of acute cytokine and antibody responses in patients infected with avian influenza A H7N9, Rui Huang, Lu Zhang, Qin Gu, Yi-Hua Zhou, Yingying Hao, Kui Zhang, Yong Liu, Danjiang Dong, Shixia Wang, Zuhu Huang, Shan Lu, and Chao Wu

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TRIF signaling is essential for TLR4-driven IgE class switching, Erin Janssen, Esra Ozcan, Kyriaki Liadaki, Haifa H. Jabara, John Manis, Sumana Ullas, Shizuo Akira, Katherine A. Fitzgerald, Douglas T. Golenbock, and Raif S. Geha

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A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling beta-glucan microparticles, Magdia De Jesus, Gary R. Ostroff, Stuart M. Levitz, Toni R. Bartling, and Nicholas J. Mantis

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Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria, Parisa Kalantari, Rosane B. DeOliveira, Jennie Chan, Yolanda Corbett, Vijay A. K. Rathinam, Andrea Stutz, Eicke Latz, Ricardo T. Gazzinelli, Douglas T. Golenbock, and Katherine A. Fitzgerald

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Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection, Varun N. Kapoor, HyunMu Shin, Ok Hyun Cho, Leslie J. Berg, Joonsoo Kang, and Raymond M. Welsh

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The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35, Chan-Hee Kim, Donggi Paik, Florentina Rus, and Neal S. Silverman

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Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity, Hye Young Kim, Hyun Jun Lee, Ya-Jen Chang, Muriel Pichavant, Stephanie A. Shore, Katherine A. Fitzgerald, Yoichiro Iwakura, Elliot Israel, Kenneth Bolger, John Faul, Rosemarie H. DeKruyff, and Dale T. Umetsu

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The Drosophila IMD pathway in the activation of the humoral immune response, Anni Kleino and Neal S. Silverman

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Optimization of transcription factor binding map accuracy utilizing knockout-mouse models, Wolfgang Krebs, Susanne V. Schmidt, Alon Goren, Dominic De Nardo, Larisa Labzin, Anton Bovier, Thomas Ulas, Heidi Theis, Michael Kraut, Eicke Latz, Marc Beyer, and Joachim L. Schultze

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Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production, Patricia Langjahr, David Diaz-Jimenez, Marjorie De la Fuente, Estefhany Rubio, Douglas T. Golenbock, Francisca C. Bronfman, Rodrigo Quera, Maria-Julieta Gonzalez, and Marcela A. Hermoso

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Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections, Daniel H. Libraty, Lei Zhang, AnaMae Obcena, Job D. Brion, and Rosario Z. Capeding

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Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model, Daniel H. Libraty, Lei Zhang, Marcia Woda, Krisanthi Giaya, Chido Loveness Kathivu, Luz P. Acosta, Veronica Tallo, Edelwisa Segubre-Mercado, Analisa Bautista, AnaMae Obcena, Job D. Brion, and Rosario Z. Capeding

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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection, Peter Liehl, Jennie Chan, Douglas T. Golenbock, Katherine A. Fitzgerald, and Maria M. Mota

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Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome, Jun Li, Yaping Han, Yiping Xing, Shuang Li, Lianhua Kong, Yongxiang Zhang, Lili Zhang, Ning Liu, Qian Wang, Shixia Wang, Shan Lu, and Zuhu Huang

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Prevalence and test characteristics of national health safety network ventilator-associated events, Craig M. Lilly, Karen Landry, Rahul N. Sood, Cheryl H. Dunnington, Richard T. Ellison III, Peter H. Bagley, Stephen P. Baker, Shawn Cody, and Richard S. Irwin

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Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011-2012): genetic characteristics of isolates with reduced sensitivity to ceftriaxone, Sai Li, Xiao-Hong Su, Wen-Jing Le, Fa-Xing Jiang, Bao-Xi Wang, and Peter A. Rice

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The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL, Zhonghan Li, Ti-Chun Chao, Kung-Yen Chang, Nianwei Lin, Veena S. Patil, Chisato Shimizu, Steven R. Head, Jane C. Burns, and Tariq M. Rana

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes, Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan, Qian Yin, Maninjay K. Atianand, Matthijn R. Vos, Gunnar F. Schroder, Katherine A. Fitzgerald, Hao Wu, and Edward H. Egelman

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Dicer's role as an antiviral: still an enigma, Christopher R. MacKay, Jennifer P. Wang, and Evelyn A. Kurt-Jones

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IKKalpha negatively regulates ASC-dependent inflammasome activation, Bradley N. Martin, Chenhui Wang, Katherine A. Fitzgerald, Yinling Hu, and Xiaoxia Li

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Elucidating the role of T cells in protection against and pathogenesis of dengue virus infections, Anuja Mathew, Elizabeth Townsley, and Francis A. Ennis

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Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals, Ryan H. Moy, Beth Gold, Jerome M. Molleston, Veronica Schad, Kilangsungla Yanger, Mary-Virginia Salzano, Yoshimasa Yagi, Katherine A. Fitzgerald, Ben Z. Stanger, Samantha S. Soldan, and Sara Cherry

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TRIM13 is a negative regulator of MDA5-mediated type I interferon production, Kavitha Narayan, Lisa Waggoner, Serena T. Pham, Gabriel L. Hendricks, Stephen N. Waggoner, Joseph E. Conlon, Jennifer P. Wang, Katherine A. Fitzgerald, and Joonso Kang

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Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection, Ribhu Nayar, Elizabeth Schutten, Bianca Bautista, Keith A. Daniels, Amanda L. Prince, Megan E. Enos, Michael A. Brehm, Susan L. Swain, Raymond M. Welsh, and Leslie J. Berg

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Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages, Sebastian Niehus, Terry K. Smith, Nahid Azzouz, Marco A. Campos, Jean-Francois Dubremetz, Ricardo T. Gazzinelli, Ralph T. Schwarz, and Francoise Debierre -Grockiego

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Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue, Samantha G. Palace, Megan K. Proulx, Shan Lu, Richard E. Baker, and Jon D. Goguen

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Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways, Amanda L. Prince, Zachary Kraus, Shannon A. Carty, Caleb Ng, Catherine C. Yin, Martha S. Jordan, Pamela L. Schwartzberg, and Leslie J. Berg

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Innate PLZF+CD4+ alphabeta T cells develop and expand in the absence of Itk, Amanda L. Prince, Levi B. Watkin, Catherine C. Yin, Liisa K. Selin, Joonso Kang, Pamela L. Schwartzberg, and Leslie J. Berg

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Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro, Nicholas Renzette, Daniel R. Caffrey, Konstantin B. Zeldovich, Ping Liu, Glen R. Gallagher, Daniel Aiello, Alyssa J. Porter, Evelyn A. Kurt-Jones, Daniel N. Bolon, Yu-Ping Poh, Jeffrey D. Jensen, Celia A. Schiffer, Timothy F. Kowalik, Robert W. Finberg, and Jennifer P. Wang

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Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways, Charles V. Rosadini, Sanjay Ram, and Brian J. Akerley

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Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation, Christian Schmidt-Lauber, Lukas Bossaller, Hani H. Abujudeh, Gregory I. Vladimer, Anette Christ, Katherine A. Fitzgerald, Eicke Latz, Ellen M. Gravallese, Ann Marshak-Rothstein, and Jonathan Kay

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The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8, Martina Severa, Sabina A. Islam, Stephen N. Waggoner, Zhaozhao Jiang, Nancy D. Kim, Glennice Bowen Ryan, Evelyn A. Kurt-Jones, Israel Charo, Daniel R. Caffrey, Victor L. Boyartchuk, Andrew D. Luster, and Katherine A. Fitzgerald

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Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever, Babs R. Soller, Anon Srikiatkhachorn, Fengmei Zou, Alan L. Rothman, In-Kyu Yoon, Robert V. Gibbons, Siripen Kalayanarooj, Stephen J. Thomas, and Sharone Green

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Age and different influenza viruses, Masanori Terajima, Mary Dawn T. Co, and Francis A. Ennis

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Interferon gamma-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses, Mikayla R. Thompson, Shrutie Sharma, Maninjay K. Atianand, Soren B. Jensen, Susan B. Carpenter, David M. Knipe, Katherine A. Fitzgerald, and Evelyn A. Kurt-Jones

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A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis, Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, and David A Thorley-Lawson

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HTT-lowering reverses Huntington's disease immune dysfunction caused by NFkappaB pathway dysregulation, Ulrike Trager, Ralph Andre, Nayana Lahiri, Anna Magnusson-Lind, Andreas Weiss, Stephan Grueninger, Chris McKinnon, Eva Sirinathsinghji, Shira Kahlon, Edith L. Pfister, Roger Moser, Holger Hummerich, Michael Antoniou, Gillian P. Bates, Ruth Luthi-Carter, Mark W. Lowdell, Maria Bjorkqvist, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Multifocal Rhizopus microsporus lung infection following brush clearing, Artsiom V. Tsyrkunou, Richard T. Ellison III, Ali Akalin, Nathan Wiederhold, Deanna A. Sutton, Jonathan Lindner, Hongxin Fan, Stuart M. Levitz, and Iva Zivna

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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome, Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian M. Skehan, Katherine A. Fitzgerald, and John M. Leong

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

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TRIL is involved in cytokine production in the brain following Escherichia coli infection, Paulina Wochal, Vijay A. K. Rathinam, Aisling Dunne, Thaddeus Carlson, Wen Kuang, Katherine J. Seidl, J. Perry Hall, Lih-Ling Lin, Mary Collins, Stefan A. Schattgen, Christopher R. MacKay, Caio T. Fagundes, Susan B. Carpenter, Katherine A. Fitzgerald, and Luke A. J. O'Neill