This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2014

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The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35, Chan-Hee Kim, Donggi Paik, Florentina Rus, and Neal S. Silverman

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Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity, Hye Young Kim, Hyun Jun Lee, Ya-Jen Chang, Muriel Pichavant, Stephanie A. Shore, Katherine A. Fitzgerald, Yoichiro Iwakura, Elliot Israel, Kenneth Bolger, John Faul, Rosemarie H. DeKruyff, and Dale T. Umetsu

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The Drosophila IMD pathway in the activation of the humoral immune response, Anni Kleino and Neal S. Silverman

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Optimization of transcription factor binding map accuracy utilizing knockout-mouse models, Wolfgang Krebs, Susanne V. Schmidt, Alon Goren, Dominic De Nardo, Larisa Labzin, Anton Bovier, Thomas Ulas, Heidi Theis, Michael Kraut, Eicke Latz, Marc Beyer, and Joachim L. Schultze

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Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production, Patricia Langjahr, David Diaz-Jimenez, Marjorie De la Fuente, Estefhany Rubio, Douglas T. Golenbock, Francisca C. Bronfman, Rodrigo Quera, Maria-Julieta Gonzalez, and Marcela A. Hermoso

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Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections, Daniel H. Libraty, Lei Zhang, AnaMae Obcena, Job D. Brion, and Rosario Z. Capeding

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Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model, Daniel H. Libraty, Lei Zhang, Marcia Woda, Krisanthi Giaya, Chido Loveness Kathivu, Luz P. Acosta, Veronica Tallo, Edelwisa Segubre-Mercado, Analisa Bautista, AnaMae Obcena, Job D. Brion, and Rosario Z. Capeding

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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection, Peter Liehl, Jennie Chan, Douglas T. Golenbock, Katherine A. Fitzgerald, and Maria M. Mota

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Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome, Jun Li, Yaping Han, Yiping Xing, Shuang Li, Lianhua Kong, Yongxiang Zhang, Lili Zhang, Ning Liu, Qian Wang, Shixia Wang, Shan Lu, and Zuhu Huang

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Prevalence and test characteristics of national health safety network ventilator-associated events, Craig M. Lilly, Karen Landry, Rahul N. Sood, Cheryl H. Dunnington, Richard T. Ellison III, Peter H. Bagley, Stephen P. Baker, Shawn Cody, and Richard S. Irwin

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Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011-2012): genetic characteristics of isolates with reduced sensitivity to ceftriaxone, Sai Li, Xiao-Hong Su, Wen-Jing Le, Fa-Xing Jiang, Bao-Xi Wang, and Peter A. Rice

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The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL, Zhonghan Li, Ti-Chun Chao, Kung-Yen Chang, Nianwei Lin, Veena S. Patil, Chisato Shimizu, Steven R. Head, Jane C. Burns, and Tariq M. Rana

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes, Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan, Qian Yin, Maninjay K. Atianand, Matthijn R. Vos, Gunnar F. Schroder, Katherine A. Fitzgerald, Hao Wu, and Edward H. Egelman

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Dicer's role as an antiviral: still an enigma, Christopher R. MacKay, Jennifer P. Wang, and Evelyn A. Kurt-Jones

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IKKalpha negatively regulates ASC-dependent inflammasome activation, Bradley N. Martin, Chenhui Wang, Katherine A. Fitzgerald, Yinling Hu, and Xiaoxia Li

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Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals, Ryan H. Moy, Beth Gold, Jerome M. Molleston, Veronica Schad, Kilangsungla Yanger, Mary-Virginia Salzano, Yoshimasa Yagi, Katherine A. Fitzgerald, Ben Z. Stanger, Samantha S. Soldan, and Sara Cherry

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TRIM13 is a negative regulator of MDA5-mediated type I interferon production, Kavitha Narayan, Lisa Waggoner, Serena T. Pham, Gabriel L. Hendricks, Stephen N. Waggoner, Joseph E. Conlon, Jennifer P. Wang, Katherine A. Fitzgerald, and Joonso Kang

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Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection, Ribhu Nayar, Elizabeth Schutten, Bianca Bautista, Keith A. Daniels, Amanda L. Prince, Megan E. Enos, Michael A. Brehm, Susan L. Swain, Raymond M. Welsh, and Leslie J. Berg

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Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages, Sebastian Niehus, Terry K. Smith, Nahid Azzouz, Marco A. Campos, Jean-Francois Dubremetz, Ricardo T. Gazzinelli, Ralph T. Schwarz, and Francoise Debierre -Grockiego

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Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue, Samantha G. Palace, Megan K. Proulx, Shan Lu, Richard E. Baker, and Jon D. Goguen

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Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways, Amanda L. Prince, Zachary Kraus, Shannon A. Carty, Caleb Ng, Catherine C. Yin, Martha S. Jordan, Pamela L. Schwartzberg, and Leslie J. Berg

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Innate PLZF+CD4+ alphabeta T cells develop and expand in the absence of Itk, Amanda L. Prince, Levi B. Watkin, Catherine C. Yin, Liisa K. Selin, Joonso Kang, Pamela L. Schwartzberg, and Leslie J. Berg

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Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro, Nicholas Renzette, Daniel R. Caffrey, Konstantin B. Zeldovich, Ping Liu, Glen R. Gallagher, Daniel Aiello, Alyssa J. Porter, Evelyn A. Kurt-Jones, Daniel N. Bolon, Yu-Ping Poh, Jeffrey D. Jensen, Celia A. Schiffer, Timothy F. Kowalik, Robert W. Finberg, and Jennifer P. Wang

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Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways, Charles V. Rosadini, Sanjay Ram, and Brian J. Akerley

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Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation, Christian Schmidt-Lauber, Lukas Bossaller, Hani H. Abujudeh, Gregory I. Vladimer, Anette Christ, Katherine A. Fitzgerald, Eicke Latz, Ellen M. Gravallese, Ann Marshak-Rothstein, and Jonathan Kay

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The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8, Martina Severa, Sabina A. Islam, Stephen N. Waggoner, Zhaozhao Jiang, Nancy D. Kim, Glennice Bowen Ryan, Evelyn A. Kurt-Jones, Israel Charo, Daniel R. Caffrey, Victor L. Boyartchuk, Andrew D. Luster, and Katherine A. Fitzgerald

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Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever, Babs R. Soller, Anon Srikiatkhachorn, Fengmei Zou, Alan L. Rothman, In-Kyu Yoon, Robert V. Gibbons, Siripen Kalayanarooj, Stephen J. Thomas, and Sharone Green

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Interferon gamma-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses, Mikayla R. Thompson, Shrutie Sharma, Maninjay K. Atianand, Soren B. Jensen, Susan B. Carpenter, David M. Knipe, Katherine A. Fitzgerald, and Evelyn A. Kurt-Jones

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A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis, Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, and David A Thorley-Lawson

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HTT-lowering reverses Huntington's disease immune dysfunction caused by NFkappaB pathway dysregulation, Ulrike Trager, Ralph Andre, Nayana Lahiri, Anna Magnusson-Lind, Andreas Weiss, Stephan Grueninger, Chris McKinnon, Eva Sirinathsinghji, Shira Kahlon, Edith L. Pfister, Roger Moser, Holger Hummerich, Michael Antoniou, Gillian P. Bates, Ruth Luthi-Carter, Mark W. Lowdell, Maria Bjorkqvist, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Multifocal Rhizopus microsporus lung infection following brush clearing, Artsiom V. Tsyrkunou, Richard T. Ellison III, Ali Akalin, Nathan Wiederhold, Deanna A. Sutton, Jonathan Lindner, Hongxin Fan, Stuart M. Levitz, and Iva Zivna

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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome, Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian M. Skehan, Katherine A. Fitzgerald, and John M. Leong

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

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TRIL is involved in cytokine production in the brain following Escherichia coli infection, Paulina Wochal, Vijay A. K. Rathinam, Aisling Dunne, Thaddeus Carlson, Wen Kuang, Katherine J. Seidl, J. Perry Hall, Lih-Ling Lin, Mary Collins, Stefan A. Schattgen, Christopher R. MacKay, Caio T. Fagundes, Susan B. Carpenter, Katherine A. Fitzgerald, and Luke A. J. O'Neill

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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors, Seng-Ryong Woo, Mercedes B. Fuertes, Leticia Corrales, Stefani Spranger, Michael J. Furdyna, Michael Y. K. Leung, Ryan Duggan, Ying Wang, Glen N. Barber, Katherine A. Fitzgerald, Maria-Luisa Alegre, and Thomas F. Gajewski

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A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination, Liusong Yin and Lawrence J. Stern

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Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization, Liusong Yin and Lawrence J. Stern

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Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide, Liusong Yin, Peter Trenh, Abigail I. Guce, Marek Wieczorek, Sascha Lange, Jana Sticht, Wei Jiang, Marissa Bylsma, Elizabeth D. Mellins, Christian Freund, and Lawrence J. Stern

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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING, Lu Zhang, Jinyao Mo, Karen V. Swanson, Haitao Wen, Alex Petrucelli, Sean M. Gregory, Zhigang Zhang, Monika Schneider, Yan Jiang, Katherine A. Fitzgerald, Songying Ouyang, Zhi-Jie Liu, Blossom Damania, Hong-Bing Shu, Joseph A. Duncan, and Jenny P-Y Ting

Publications from 2013

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Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome, Ali A. Abdul-Sater, Ivan Tattoli, Lei Jin, Andrzej Grajkowski, Assaf Levi, Beverly H. Koller, Irving C. Allen, Serge L. Beaucage, Katherine A. Fitzgerald, Jenny P-Y. Ting, John C. Cambier, Stephen E. Girardin, and Christian Schindler

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Cross reactivity of serum antibody responses elicited by DNA vaccines expressing HA antigens from H1N1 subtype influenza vaccines in the past 30 years, Iman Almansour, Huaiqing Chen, Shixia Wang, and Shan Lu

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Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice, Warrison A. Andrade, Maria do Carmo Souza, Espiridion Ramos-Martinez, Kamalpreet Nagpal, Miriam S. Dutra, Mariane B. Melo, Daniella C. Bartholomeu, Sankar Ghosh, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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Molecular basis of DNA recognition in the immune system, Maninjay K. Atianand and Katherine A. Fitzgerald

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SnapShot: inflammasomes, Maninjay K. Atianand, Vijay A. K. Rathinam, and Katherine A. Fitzgerald

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Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus, Lukas Bossaller, Vijay A. K. Rathinam, Ramon Bonegio, Ping-I Chang, Patricia Busto, Adam R. Wespiser, Daniel R. Caffrey, Quan-Zhen Li, Chandra Mohan, Katherine A. Fitzgerald, Eicke Latz, and Ann Marshak-Rothstein

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Monoclonal antibody treatments for rheumatoid arthritis, Lukas Bossaller and Achim Rothe

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Innate sensing of chitin and chitosan, Chelsea L. Bueter, Charles A. Specht, and Stuart M. Levitz

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Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy, Rachel Buglione-Corbett, Kimberly Lea Pouliot, Robyn Lynn Marty-Roix, Kim West, Shixia Wang, Egil Lien, and Shan Lu

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A long noncoding RNA mediates both activation and repression of immune response genes, Susan Carpenter, Daniel Aiello, Maninjay K. Atianand, Emiliano P. Ricci, Pallavi Gandhi, Lisa L. Hall, Meg Byron, Brian G. Monks, Meabh Henry-Bezy, Jeanne B. Lawrence, Luke A. J. O'Neill, Melissa J. Moore, Daniel R. Caffrey, and Katherine A. Fitzgerald

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Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-gamma responses before antiretroviral therapy but not higher T-cell responses during therapy, Christina C. Chang, Andrew Lim, Saleha Omarjee, Stuart M. Levitz, Bernadett I. Gosnell, Tim Spelman, Julian H. Elliott, William H. Carr, Mohamed-Yunus S. Moosa, Thumbi Ndung'u, Sharon R. Lewin, and Martyn A. French

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A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design, Yuxin Chen, Michael Vaine, Aaron Wallace, Dong Han, Shengqin Wan, Michael S. Seaman, David C. Montefiori, Shixia Wang, and Shan Lu

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Novel strategies to enhance vaccine immunity against coccidioidomycosis, Garry T. Cole, Chiung-Yu Hung, Sam D. Sanderson, Brady J. Hurtgen, Marcel Wuthrich, Bruce S. Klein, George S. Deepe, Gary R. Ostroff, and Stuart M. Levitz

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Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid, Joseph E. Conlon, Dara Burdette, Shrutie Sharma, Numana Bhat, Mikayla R. Thompson, Zhaozhao Jiang, Vijay A. K. Rathinam, Brian G. Monks, Tengchuan Jin, T. Sam Xiao, Stefanie N. Vogel, Russell E. Vance, and Katherine A. Fitzgerald

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Human papillomavirus E7 induces rereplication in response to DNA damage, Xueli Fan, Yingwang Liu, Susan Ann Heilman, and Jason J. Chen

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East North Central region has the highest prevalence of vancomycin-resistant Enterococcus faecalis in the United States, Sumanth Gandra, Nikolay Braykov, and Ramanan Laxminarayan

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DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus, Anna Gil, Siyuan Shen, Scott Coley, Laura Gibson, Don J. Diamond, Shixia Wang, and Shan Lu

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Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection, Sunita Gulati, Bo Zheng, George W. Reed, Xiaohong Su, Andrew D. Cox, Frank St. Michael, Jacek Stupak, Lisa A. Lewis, Sanjay Ram, and Peter A. Rice

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C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness, John Patrick Haran, Francesca Lynn Beaudoin, Selim Suner, and Shan Lu

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Cytokine markers as predictors of type of respiratory infection in patients during the influenza season, John Patrick Haran, Rachel Buglione-Corbett, and Shan Lu

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Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus, Gabriel L. Hendricks, Kim L. Weirich, Karthik Viswanathan, Jing Li, Zachary H. Shriver, Joseph Ashour, Hidde L. Ploegh, Evelyn A. Kurt-Jones, Deborah K. Fygenson, Robert W. Finberg, James C. Comolli, and Jennifer P. Wang

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Characterization and optimization of the glucan particle-based vaccine platform, Haibin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation, John J. Kaminski III, Stefan A. Schattgen, TeChen Tzeng, Christian Bode, Dennis M. Klinman, and Katherine A. Fitzgerald

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Factor H-Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis, Lisa A. Lewis, David M. Vu, Shreekant Vasudhev, Jutamas Shaughnessy, Dan M. Granoff, and Sanjay Ram

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Breastfeeding During Early Infancy is Associated with a Lower Incidence of Febrile Illnesses, Daniel H. Libraty, Rosario Z. Capeding, Anamae Obcena, Job D. Brion, and Veronica Tallo

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Breastfeeding During Early Infancy is Associated with Higher Weight-Based World Health Organization Anthropometry, Daniel H. Libraty, Rosario Z. Capeding, Anamae Obcena, Job D. Brion, and Veronica Tallo

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Toll-like receptor induced pro-interleukin-1beta and interleukin-6 in monocytes are lower in healthy infants compared to adults, Daniel H. Libraty, Lei Zhang, Marcia Woda, Luz P. Acosta, Anamae Obcena, Job D. Brion, and Rosario Z. Capeding

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Quality measures for critically ill patients: where does ventilator-associated condition fit in, Craig M. Lilly and Richard T. Ellison III

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Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice, Dora Lippai, Shashi Bala, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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The role of MyD88 signaling in heterosubtypic influenza A virus infections, Rachel F. Madera and Daniel H. Libraty

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The genome of Anopheles darlingi, the main neotropical malaria vector, Osvaldo Marinotti, Adam R. Wespiser, Daniel R. Caffrey, Douglas T. Golenbock, and Neal S. Silverman

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(De-) oiling inflammasomes, Robyn Lynn Marty-Roix and Egil Lien

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Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways, Mariane B. Melo, Quynh P. Nguyen, Cynthia Cordeiro, Musa A. Hassan, Ninghan Yang, Renee McKell, Emily E. Rosowski, Lindsay Julien, Vincent Butty, Marie-Laure Darde, Daniel Ajzenberg, Katherine A. Fitzgerald, Lucy H. Young, and Jeroen P. J. Saeij

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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta, Bibhuti B. Mishra, Vijay A. K. Rathinam, Gregory W. Martens, Amanda J. Martinot, Hardy Kornfeld, Katherine A. Fitzgerald, and Christopher M. Sassetti

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Telomere length dynamics in human memory T cells specific for viruses causing acute or latent infections, Joel M. O'Bryan, Marcia Woda, Mary Dawn T. Co, Anuja Mathew, and Alan Rothman

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Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism, Olivia J. O'Connell, Alexander Repik, Jacqueline D. Reeves, Maria Paz Gonzalez-Perez, Briana Quitadamo, Elizabeth D. Anton, Maria J. Duenas-Decamp, Paul J. Peters, Rongheng Lin, Susan Zolla-Pazner, Davide Corti, Aaron Wallace, Shixia Wang, Xiang-Peng Kong, Shan Lu, and Paul R. Clapham

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Dengue virus type 2 modulates endothelial barrier function through CD73, Chinmay Patkar, Krisanthi Giaya, and Daniel H. Libraty

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo

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Effect of Race/Ethnicity and Socioeconomic Status on Pandemic H1N1-Related Outcomes in Massachusetts, Hilary Placzek and Lawrence C. Madoff

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Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection, Nicholas Renzette, Laura L. Gibson, Bornali Bhattacharjee, Donna Fisher, Mark R. Schleiss, Jeffrey D. Jensen, and Timothy F. Kowalik

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Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld

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Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity, Florentina Rus, Thomas Flatt, Mei Tong, Kamna Aggarwal, Kendi Okuda, Anni Kleino, Elisabeth Yates, Marc Tatar, and Neal S. Silverman

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UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major, Bruno Luiz Fonseca Schamber-Reis, Patricia M. Petritus, Braulia C. Caetano, Espiridion R. Martinez, Kendi Okuda, Douglas T. Golenbock, Phillip Scott, and Ricardo T. Gazzinelli

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UPF1 is Crucial for the Infectivity of Human Immunodeficiency Virus type 1 Progeny Virions, Anna Kristina Serquina, Suman R. Das, Elena Popova, Ogooluwa A. Ojelabi, Christian K. Roy, and Heinrich G. Gottlinger

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Epigenetic Modifications Induced by Blimp-1 Regulate CD8(+) T Cell Memory Progression during Acute Virus Infection, Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, and Leslie J. Berg

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Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1beta response and host resistance to Trypanosoma cruzi infection, Grace Kelly Silva, Renata Sesti Costa, Tatiana Nunes Silveira, Braulia C. Caetano, Catarina Veltrini Horta, Fredy Roberto Gutierrez-Salazar, Paulo Marcos da Matta Guedes, Warrison A. Andrade, Mariana De Niz, Ricardo T. Gazzinelli, Dario Simoes Zamboni, and Joao Santana Silva

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RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA, Cherilyn M. Sirois, Tengchuan Jin, Allison L. Miller, Damien Bertheloot, Hirotaka Nakamura, Gabor Horvath, Abubakar Mian, Jiansheng Jiang, Jacob Schrum, Lukas Bossaller, Karin Pelka, Natalio Garbi, Yambasu Brewah, Jane Tian, ChewShun Chang, Partha S. Chowdhury, Gary P. Sims, Roland Kolbeck, Anthony J. Coyle, Alison A. Humbles, T. Sam Xiao, and Eicke Latz

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Cross-reactive human B cell and T cell epitopes between influenza A and B viruses, Masanori Terajima, Jenny Aurielle B. Babon, Mary Dawn T. Co, and Francis A. Ennis

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The N-terminus of vaccinia virus host range protein C7L is essential for function, Masanori Terajima, Stina L. Urban, and Anita M. Leporati

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Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation, Christine Vaine, Milan K. Patel, Jintao Zhu, Eunji Lee, Robert W. Finberg, Ryan C. Hayward, and Evelyn A. Kurt-Jones

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Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien

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Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1), Aaron Wallace, Kim West, Alan L. Rothman, Francis A. Ennis, Shan Lu, and Shixia Wang

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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins, Donghai Wang, Susanne Hoing, Heide Christine Patterson, Umtul M. Ahmad, Vijay A. K. Rathinam, Klaus Rajewsky, Katherine A. Fitzgerald, and Douglas T. Golenbock

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DNA immunization, Shixia Wang and Shan Lu

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Dermatophagoides pteronyssinus Major Allergen 1 Activates the Innate Immune Response of the Fruit Fly Drosophila melanogaster, Christine Warmbold, Karin Uliczka, Florentina Rus, Roland Suck, Arnd Petersen, Neal S. Silverman, Artur J. Ulmer, Holger Heine, and Thomas Roeder

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CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans, Liusong Yin, J. Mauricio Calvo-Calle, John Cruz Jr., Frances K. Newman, Sharon E. Frey, Francis A. Ennis, and Lawrence J. Stern

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Potent monoclonal antibodies against Clostridium difficile toxin A elicited by DNA immunization, Chunhua Zhang, Ke Jin, Yanling Xiao, Ying Cheng, Zuhu Huang, Shixia Wang, and Shan Lu

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Malaria and other Vector-Borne Illnesses, Iva Zivna and Richard T. Ellison III

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Severe Community-Acquired Respiratory Viral Infections, Iva Zivna and Richard T. Ellison III