Title

Interferon gene regulation: not all roads lead to Tolls

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

8-13-2005

Document Type

Article

Subjects

Animals; Dendritic Cells; *Gene Expression Regulation; Humans; Interferons; RNA Helicases; Signal Transduction; Toll-Like Receptors

Disciplines

Immunology and Infectious Disease

Abstract

Many infectious agents elicit a type I interferon response but, until recently, the molecular details that coordinate interferon (IFN)-alpha and -beta expression during infection were unknown. Innate immune pattern recognition receptors, including Toll-like receptors and cytoplasmic RNA helicases such as retinoic acid-inducible gene, that sense viral nucleic acids have been discovered. Using distinct mechanisms, these receptors trigger cellular signaling pathways, culminating in the activation of interferon regulatory factors that transcriptionally induce IFN-alpha and IFN-beta genes.

Rights and Permissions

Citation: Trends Mol Med. 2005 Sep;11(9):403-11. Link to article on publisher's site

Journal/Book/Conference Title

Trends in molecular medicine

Related Resources

Link to Article in PubMed

PubMed ID

16095970