Interferon gene regulation: not all roads lead to Tolls

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type



Animals; Dendritic Cells; *Gene Expression Regulation; Humans; Interferons; RNA Helicases; Signal Transduction; Toll-Like Receptors


Immunology and Infectious Disease


Many infectious agents elicit a type I interferon response but, until recently, the molecular details that coordinate interferon (IFN)-alpha and -beta expression during infection were unknown. Innate immune pattern recognition receptors, including Toll-like receptors and cytoplasmic RNA helicases such as retinoic acid-inducible gene, that sense viral nucleic acids have been discovered. Using distinct mechanisms, these receptors trigger cellular signaling pathways, culminating in the activation of interferon regulatory factors that transcriptionally induce IFN-alpha and IFN-beta genes.

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Citation: Trends Mol Med. 2005 Sep;11(9):403-11. Link to article on publisher's site

Journal/Book/Conference Title

Trends in molecular medicine

Related Resources

Link to Article in PubMed

PubMed ID