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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2005-08-13Keywords
AnimalsDendritic Cells
*Gene Expression Regulation
Humans
Interferons
RNA Helicases
Signal Transduction
Toll-Like Receptors
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Many infectious agents elicit a type I interferon response but, until recently, the molecular details that coordinate interferon (IFN)-alpha and -beta expression during infection were unknown. Innate immune pattern recognition receptors, including Toll-like receptors and cytoplasmic RNA helicases such as retinoic acid-inducible gene, that sense viral nucleic acids have been discovered. Using distinct mechanisms, these receptors trigger cellular signaling pathways, culminating in the activation of interferon regulatory factors that transcriptionally induce IFN-alpha and IFN-beta genes.Source
Trends Mol Med. 2005 Sep;11(9):403-11. Link to article on publisher's siteDOI
10.1016/j.molmed.2005.07.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35255PubMed ID
16095970Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.molmed.2005.07.006