Title

Molecular mechanisms involved in inflammasome activation

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

9-1-2009

Document Type

Article

Subjects

Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Caspase 1; Humans; Inflammation; Receptors, G-Protein-Coupled; Signal Transduction

Abstract

Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous products released from damaged or dying cells and trigger innate immunity. In most cases, sensing of these signals is coupled to signal transduction pathways that lead to transcription of immune response genes that combat infection or lead to cell death. Members of the NOD-like receptor (NLR) family assemble into large multiprotein complexes, termed inflammasomes. Inflammasomes do not regulate transcription of immune response genes, but activate caspase-1, a proteolytic enzyme that cleaves and activates the secreted cytokines interleukin-1beta and interleukin-18. Inflammasomes also regulate pyroptosis, a caspase-1-dependent form of cell death that is highly inflammatory. Here, we review exciting recent developments on the role of inflammasome complexes in host defense and the discovery of a new DNA sensing inflammasome, and describe important progress made in our understanding of how inflammasomes are activated. Additionally, we highlight how dysregulation of inflammasomes contributes to human disease.

Rights and Permissions

Citation: Trends Cell Biol. 2009 Sep;19(9):455-64. Epub 2009 Aug 26. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

19716304