Title

Integr-ating IL-1 alpha in antiviral host defenses

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

7-17-2009

Document Type

Article

Subjects

Adenoviridae; Animals; Gene Therapy; Genetic Vectors; Immunity, Innate; Inflammation; Integrin beta3; Interleukin-1alpha; Mice

Abstract

Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.

Rights and Permissions

Citation: Immunity. 2009 Jul 17;31(1):7-9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

19604487