Integr-ating IL-1 alpha in antiviral host defenses
Department of Medicine, Division of Infectious Diseases and Immunology
Adenoviridae; Animals; Gene Therapy; Genetic Vectors; Immunity, Innate; Inflammation; Integrin beta3; Interleukin-1alpha; Mice
Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.
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Citation: Immunity. 2009 Jul 17;31(1):7-9. Link to article on publisher's site