Catenin' on to nucleic acid sensing
Department of Medicine, Division of Infectious Diseases and Immunology
Catenins; Humans; Immunity, Innate; Interferon Regulatory Factor-3; Interferon Type I; Listeria monocytogenes; Protein-Serine-Threonine Kinases; RNA-Binding Proteins; Signal Transduction; Vesicular Stomatitis
Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.
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Citation: Nat Immunol. 2010 Jun;11(6):466-8. Link to article on publisher's site