Title

Catenin' on to nucleic acid sensing

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

5-21-2010

Document Type

Article

Subjects

Catenins; Humans; Immunity, Innate; Interferon Regulatory Factor-3; Interferon Type I; Listeria monocytogenes; Protein-Serine-Threonine Kinases; RNA-Binding Proteins; Signal Transduction; Vesicular Stomatitis

Abstract

Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.

Rights and Permissions

Citation: Nat Immunol. 2010 Jun;11(6):466-8. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

20485273