Title
Viral defense: it takes two MAVS to Tango
UMMS Affiliation
Department of Medicine, Division of Infectious Diseases and Immunology
Date
5-19-2010
Document Type
Article
Subjects
Adaptor Proteins, Signal Transducing
Abstract
To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.
Rights and Permissions
Citation: Cell. 2010 May 14;141(4):570-2. Link to article on publisher's site
Related Resources
PubMed ID
20478250
COinS