Viral defense: it takes two MAVS to Tango
Department of Medicine, Division of Infectious Diseases and Immunology
Adaptor Proteins, Signal Transducing
To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.
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Citation: Cell. 2010 May 14;141(4):570-2. Link to article on publisher's site