Title

Viral defense: it takes two MAVS to Tango

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

5-19-2010

Document Type

Article

Subjects

Adaptor Proteins, Signal Transducing

Disciplines

Immunology and Infectious Disease

Abstract

To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.

Rights and Permissions

Citation: Cell. 2010 May 14;141(4):570-2. Link to article on publisher's site

Journal/Book/Conference Title

Cell

Related Resources

Link to Article in PubMed

PubMed ID

20478250