Title

Peptidoglycan recognition in Drosophila

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

11-23-2007

Document Type

Article

Subjects

Animals; Bacteria; Carrier Proteins; Drosophila; Models, Immunological; Peptidoglycan; Signal Transduction

Disciplines

Immunology and Infectious Disease

Abstract

Drosophila rely primarily on innate immune responses to effectively combat a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of AMPs (antimicrobial peptides) by the fat body, the insect homologue of the mammalian liver. Production of these AMPs is controlled at the level of transcription by two NF-kappaB (nuclear factor kappaB) signalling pathways. The Toll pathway is activated by fungal and many Gram-positive bacterial microbes, whereas the IMD (immune deficiency) pathway responds to Gram-negative bacteria and certain Gram-positive bacilli. In the present review, we discuss the mechanisms involved in bacterial recognition, in particular the differential recognition of various types of bacterial PGN (peptidoglycan) by different members of the PGRP (PGN recognition protein) family of receptors.

Rights and Permissions

Citation: Biochem Soc Trans. 2007 Dec;35(Pt 6):1496-500. Link to article on publisher's site

Journal/Book/Conference Title

Biochemical Society transactions

Related Resources

Link to Article in PubMed

PubMed ID

18031252