Immunologic responses to vaccinia vaccines administered by different parenteral routes
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification. Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions. Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses.
J Infect Dis. 1997 Apr;175(4):756-63. DOI: 10.1086/513968
McClain, David J.; Harrison, Shannon; Yeager, Curtis L.; Cruz, John; Ennis, Francis A.; Gibbs, Paul; Wright, Michael S.; Summers, Peter L.; Arthur, James D.; and Graham, Jess A., "Immunologic responses to vaccinia vaccines administered by different parenteral routes" (1997). Infectious Diseases and Immunology Publications and Presentations. 307.