Dengue in the early febrile phase: viremia and antibody responses
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology
A multicenter effort was begun in 1994 to characterize the pathophysiology of dengue using a study design that minimized patient selection bias by offering enrollment to all children with undifferentiated fever for < 72 h. In the first year, 189 children were enrolled (age range, 8 months to 14 years). Thirty-two percent of these children had dengue infections (60 volunteers). The percentage of children with a secondary dengue infection was 93%, with only 4 (7%) having a primary dengue infection. The virus isolation rate from the plasma of children with dengue was 98%. Viremia correlated highly with temperature. All four dengue virus serotypes were isolated at both study sites. This study demonstrates that all four serotypes of dengue virus can cause dengue hemorrhagic fever, that all dengue patients as defined by serology experience viremia during the febrile phase, and that as fever subsides, so does viremia.
J Infect Dis. 1997 Aug;176(2):322-30. DOI: 10.1086/514048
Vaughn, David W.; Green, Sharone; Kalayanarooj, Siripen; Innis, B. L.; Nimmannitaya, Suchitra; Suntayakorn, Saroj; Rothman, Alan L.; Ennis, Francis A.; and Nisalak, Ananda, "Dengue in the early febrile phase: viremia and antibody responses" (1997). Infectious Diseases and Immunology Publications and Presentations. 304.