Mechanisms of inflammasome activation: recent advances and novel insights
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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate ImmunityDocument Type
Journal ArticlePublication Date
2015-05-01
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Show full item recordAbstract
Inflammasomes are cytosolic multiprotein platforms assembled in response to invading pathogens and other danger signals. Typically inflammasome complexes contain a sensor protein, an adaptor protein, and a zymogen - procaspase-1. Formation of inflammasome assembly results in processing of inactive procaspase-1 into an active cysteine-protease enzyme, caspase-1, which subsequently activates the proinflammatory cytokines, interleukins IL-1beta and IL-18, and induces pyroptosis, a highly-pyrogenic inflammatory form of cell death. Studies over the past year have unveiled exciting new players and regulatory pathways that are involved in traditional inflammasome signaling, some of them even challenging the existing dogma. This review outlines these new insights in inflammasome research and discusses areas that warrant further exploration.Source
Trends Cell Biol. 2015 May;25(5):308-315. doi: 10.1016/j.tcb.2014.12.009. Link to article on publisher's siteDOI
10.1016/j.tcb.2014.12.009Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34971PubMed ID
25639489Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.tcb.2014.12.009