Title

Long non-coding RNAs and control of gene expression in the immune system

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity

Publication Date

11-2014

Document Type

Article

Disciplines

Genetic Processes | Immunity | Immunology and Infectious Disease | Immunology of Infectious Disease | Infectious Disease | Molecular Biology | Molecular Genetics

Abstract

All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.

Rights and Permissions

Citation: Trends Mol Med. 2014 Nov;20(11):623-631. doi: 10.1016/j.molmed.2014.09.002. Epub 2014 Sep 25. Link to article on publisher's site

Journal/Book/Conference Title

Trends in molecular medicine

Related Resources

Link to Article in PubMed

PubMed ID

25262537