Long non-coding RNAs and control of gene expression in the immune system
Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity
All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.
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Citation: Trends Mol Med. 2014 Nov;20(11):623-631. doi: 10.1016/j.molmed.2014.09.002. Epub 2014 Sep 25. Link to article on publisher's site
Atianand, Maninjay K. and Fitzgerald, Katherine A., "Long non-coding RNAs and control of gene expression in the immune system" (2014). Infectious Diseases and Immunology Publications and Presentations. 164.