Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond
Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity
The innate immune system must coordinate elaborate signaling pathways to turn on expression of hundreds of genes to provide protection against pathogens and resolve acute inflammation. Multiple genes within distinct functional categories are coordinately and temporally regulated by transcriptional on and off switches in response to distinct external stimuli. Three classes of transcription factors act together with transcriptional coregulators and chromatin-modifying complexes to control these programs. In addition, newer studies implicate long noncoding RNA (lncRNA) as additional regulators of these responses. LncRNAs promote, fine-tune, and restrain the inflammatory program. In this study, we provide an overview of gene regulation and the emerging importance of lncRNAs in the immune system.
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Citation: J Interferon Cytokine Res. 2014 Sep 24. Link to article on publisher's site
Carpenter, Susan B. and Fitzgerald, Katherine A., "Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond" (2014). Infectious Diseases and Immunology Publications and Presentations. 163.