Title

Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity

Publication Date

9-24-2014

Document Type

Article

Disciplines

Genetic Processes | Genetic Structures | Immunity | Molecular Genetics

Abstract

The innate immune system must coordinate elaborate signaling pathways to turn on expression of hundreds of genes to provide protection against pathogens and resolve acute inflammation. Multiple genes within distinct functional categories are coordinately and temporally regulated by transcriptional on and off switches in response to distinct external stimuli. Three classes of transcription factors act together with transcriptional coregulators and chromatin-modifying complexes to control these programs. In addition, newer studies implicate long noncoding RNA (lncRNA) as additional regulators of these responses. LncRNAs promote, fine-tune, and restrain the inflammatory program. In this study, we provide an overview of gene regulation and the emerging importance of lncRNAs in the immune system.

Rights and Permissions

Citation: J Interferon Cytokine Res. 2014 Sep 24. Link to article on publisher's site

Journal/Book/Conference Title

Journal of interferon and cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Related Resources

Link to Article in PubMed

PubMed ID

25250698