Title

Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

5-7-2013

Document Type

Article

Subjects

Ecdysone; Steroids; Carrier Proteins; Drosophila; Drosophila Proteins; Immunity, Innate

Abstract

Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. We identify a group of steroid-regulated transcription factors as well as two GATA transcription factors that act as repressors and activators of the immune response and are required for the proper hormonal control of PGRP-LC expression. Together, our results demonstrate that Drosophila use complex mechanisms to modulate innate immune responses, and identify a transcriptional hierarchy that integrates steroid signalling and immunity in animals.

Comments

Citation: EMBO J. 2013 May 7. doi: 10.1038/emboj.2013.100.

Related Resources

Link to article in PubMed

PubMed ID

23652443