Title

UnZIPping mechanisms of effector-triggered immunity in animals

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

4-19-2012

Document Type

Response or Comment

Subjects

Bacterial Toxins; Caenorhabditis elegans; Exotoxins; Protein Biosynthesis; Pseudomonas Infections; Pseudomonas aeruginosa

Abstract

The mechanisms by which epithelial cells distinguish pathogens from commensal microbes have long puzzled us. Now, McEwan et al. (2012) and Dunbar et al. (2012), in this issue of Cell Host and Microbe, demonstrate that in C. elegans, microbial toxin-induced inhibition of host cellular functions, especially blockade of protein translation, activates the effector-triggered immune response dependent on the transcription factor ZIP-2.

Comments

Citation: Cell Host Microbe. 2012 Apr 19;11(4):320-2. doi: 10.1016/j.chom.2012.04.002. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

22520459