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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Response or CommentPublication Date
2012-04-19Keywords
Bacterial ToxinsCaenorhabditis elegans
Exotoxins
Protein Biosynthesis
Pseudomonas Infections
Pseudomonas aeruginosa
Immunology and Infectious Disease
Microbiology
Metadata
Show full item recordAbstract
The mechanisms by which epithelial cells distinguish pathogens from commensal microbes have long puzzled us. Now, McEwan et al. (2012) and Dunbar et al. (2012), in this issue of Cell Host and Microbe, demonstrate that in C. elegans, microbial toxin-induced inhibition of host cellular functions, especially blockade of protein translation, activates the effector-triggered immune response dependent on the transcription factor ZIP-2.Source
Cell Host Microbe. 2012 Apr 19;11(4):320-2. doi: 10.1016/j.chom.2012.04.002. Link to article on publisher's site
DOI
10.1016/j.chom.2012.04.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34929PubMed ID
22520459Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.chom.2012.04.002