UnZIPping mechanisms of effector-triggered immunity in animals
Department of Medicine, Division of Infectious Diseases and Immunology
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Bacterial Toxins; Caenorhabditis elegans; Exotoxins; Protein Biosynthesis; Pseudomonas Infections; Pseudomonas aeruginosa
The mechanisms by which epithelial cells distinguish pathogens from commensal microbes have long puzzled us. Now, McEwan et al. (2012) and Dunbar et al. (2012), in this issue of Cell Host and Microbe, demonstrate that in C. elegans, microbial toxin-induced inhibition of host cellular functions, especially blockade of protein translation, activates the effector-triggered immune response dependent on the transcription factor ZIP-2.