Title
Regulation of inflammasome signaling
UMMS Affiliation
Department of Medicine, Division of Infectious Diseases and Immunology
Date
3-19-2012
Document Type
Article
Subjects
Animals; Humans; Immunity, Innate; Inflammasomes; Signal Transduction
Abstract
Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1beta (IL-1beta), IL-18 and pyroptosis. Inflammasomes recognize microbial products or endogenous molecules released from damaged or dying cells both through direct binding of ligands and indirect mechanisms. The potential of the IL-1 family of cytokines to cause tissue damage and chronic inflammation emphasizes the importance of regulating inflammasomes. Many regulatory mechanisms have been identified that act as checkpoints for attenuating inflammasome signaling at multiple steps. Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance.
Related Resources
PubMed ID
22430786
Comments
Citation: Nat Immunol. 2012 Mar 19;13(4):333-2. doi: 10.1038/ni.2237. Link to article on publisher's site