UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2012-03-19Keywords
AnimalsHumans
Immunity, Innate
Inflammasomes
Signal Transduction
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1beta (IL-1beta), IL-18 and pyroptosis. Inflammasomes recognize microbial products or endogenous molecules released from damaged or dying cells both through direct binding of ligands and indirect mechanisms. The potential of the IL-1 family of cytokines to cause tissue damage and chronic inflammation emphasizes the importance of regulating inflammasomes. Many regulatory mechanisms have been identified that act as checkpoints for attenuating inflammasome signaling at multiple steps. Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance.Source
Nat Immunol. 2012 Mar 19;13(4):333-2. doi: 10.1038/ni.2237. Link to article on publisher's siteDOI
10.1038/ni.2237Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34926PubMed ID
22430786Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/ni.2237