Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
Department of Medicine, Division of Infectious Diseases and Immunology
Animals; Antigens, Bacterial; Drosophila; *Drosophila Proteins; Gene Expression Regulation; I-kappa B Kinase; Immunity, Natural; Insect Proteins; Membrane Glycoproteins; Protein-Serine-Threonine Kinases; *Receptors, Cell Surface; Signal Transduction; Toll-Like Receptors; Transcription Factors
We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila.
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Citation: Nat Immunol. 2000 Oct;1(4):342-7. Link to article on publisher's site