Title

Sorting out Toll signals

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

6-6-2006

Document Type

Article

Subjects

Adaptor Proteins, Signal Transducing; Animals; Humans; Membrane Glycoproteins; Membrane Lipids; Myeloid Differentiation Factor 88; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Protein Transport; Receptors, Interleukin-1; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors

Disciplines

Immunology and Infectious Disease

Abstract

Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

Rights and Permissions

Citation: Cell. 2006 Jun 2;125(5):834-6. Link to article on publisher's site

Journal/Book/Conference Title

Cell

Related Resources

Link to Article in PubMed

PubMed ID

16751092