Sorting out Toll signals
Department of Medicine, Division of Infectious Diseases and Immunology
Adaptor Proteins, Signal Transducing; Animals; Humans; Membrane Glycoproteins; Membrane Lipids; Myeloid Differentiation Factor 88; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Protein Transport; Receptors, Interleukin-1; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.
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Citation: Cell. 2006 Jun 2;125(5):834-6. Link to article on publisher's site