TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2007-11-01Keywords
AnimalsHumans
Interferon Regulatory Factors
Interferon Type I
Toll-Like Receptors
Virus Diseases
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Toll-like receptors (TLRs) are crucially important in the sensing of viral infections and viral nucleic acids. TLR triggering leads to the induction of specific intracellular signaling cascades that result in the activation of two major families of transcription factors; the IFN-regulatory factors (IRFs) and nuclear factor-kappa B (NF-kappaB). IRFs and NF-kappaB work together to trigger the production of type I interferons (IFNalpha/beta) or inflammatory cytokines leading to the maturation of dendritic cells and the establishment of antiviral immunity. This review will focus on the most recent findings relating to the regulation of IRF activity by TLRs, highlighting the increasing complexity of TLR-mediated signaling pathways.Source
Curr Top Microbiol Immunol. 2007;316:167-92. DOI: 10.1007/978-3-540-71329-6DOI
10.1007/978-3-540-71329-6Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34895PubMed ID
17969448Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/978-3-540-71329-6