The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
Department of Medicine, Division of Infectious Diseases and Immunology
Alzheimer Disease; Amyloid beta-Peptides; Carrier Proteins; Immunity, Innate; Inflammation; Inflammation Mediators
The fibrillar peptide amyloid-beta (A beta) has a chief function in the pathogenesis of Alzheimer's disease. Interleukin 1 beta (IL-1 beta) is a key cytokine in the inflammatory response to A beta. Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in the release of IL-1 beta. Here we identify the NALP3 inflammasome as a sensor of A beta in a process involving the phagocytosis of A beta and subsequent lysosomal damage and release of cathepsin B. Furthermore, the IL-1 beta pathway was essential for the microglial synthesis of proinflammatory and neurotoxic factors, and the inflammasome, caspase-1 and IL-1 beta were critical for the recruitment of microglia to exogenous A beta in the brain. Our findings suggest that activation of the NALP3 inflammasome is important for inflammation and tissue damage in Alzheimer's disease.
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Citation: Nat Immunol. 2008 Aug;9(8):857-65. Epub 2008 Jul 11. Link to article on publisher's site
Halle, Annett; Hornung, Veit; Petzold, Gabor C.; Stewart, Cameron R.; Monks, Brian G.; Reinheckel, Thomas; Fitzgerald, Katherine A.; Latz, Eicke; Moore, Kathryn J.; and Golenbock, Douglas T., "The NALP3 inflammasome is involved in the innate immune response to amyloid-beta" (2008). Infectious Diseases and Immunology Publications and Presentations. 120.