UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2011-02-27Keywords
Immunity, InnateReceptors, Pattern Recognition
Herpesviridae
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both on the cell surface and within endosomes and the cytosol. In this article we describe recent advances in our understanding of innate detection of herpesviruses, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate detection to establish persistent infections.Source
Nat Rev Immunol. 2011 Feb;11(2):143-54. Link to article on publisher's siteDOI
10.1038/nri2937Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34879PubMed ID
21267015Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/nri2937