Innate immune sensing of DNA viruses
Department of Medicine, Division of Infectious Diseases and Immunology
Immunity, Innate; DNA Viruses; DNA Virus Infections
DNA viruses are a significant contributor to human morbidity and mortality. The immune system protects against viral infections through coordinated innate and adaptive immune responses. While the antigen-specific adaptive mechanisms have been extensively studied, the critical contributions of innate immunity to anti-viral defenses have only been revealed in the very recent past. Central to these anti-viral defenses is the recognition of viral pathogens by a diverse set of germ-line encoded receptors that survey nearly all cellular compartments for the presence of pathogens. In this review, we discuss the recent advances in the innate immune sensing of DNA viruses and focus on the recognition mechanisms involved.
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Citation: Virology. 2011 Mar 15;411(2):153-62. Epub 2011 Feb 18. Link to article on publisher's site