The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence
Department of Medicine, Division of Infectious Diseases and Immunology
Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation; *Drosophila Proteins; Forecasting; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Immunity, Innate; Inflammation; Membrane Glycoproteins; Myeloid Differentiation Factor 88; Plant Diseases; Plant Proteins; Receptors, Cell Surface; *Receptors, Immunologic; Receptors, Interleukin-1; Toll-Like Receptors
The IL-1 receptor/Toll-like receptor superfamily comprises a diverse family of cell surface receptors defined by a characteristic conserved sequence in their cytosolic regions, termed the Toll/IL-1 receptor domain, which function in inflammation and host defence against microbial pathogens. Members include receptors for the proinflammatory cytokines IL-1 and IL-18 and Toll-like receptors 2 and 4, which are involved in host responses to Gram-positive and Gram-negative bacteria, respectively. Signalling pathways activated by these receptors are conserved and the superfamily represents a pan-genomic system involved in the host response to infection and injury.
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Citation: Microbes Infect. 2000 Jul;2(8):933-43.