This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Department of Medicine's Division of Infectious Diseases and Immunology.

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Publications from 2017

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Immunobiology of Long Noncoding RNAs, Maninjay K. Atianand, Daniel R. Caffrey, and Katherine A. Fitzgerald

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BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV, Anne K. Barasa, Peng Ye, Meredith Phelps, Ganapathiram T. Arivudainambi, Timelia Tison, and Javier Gordon Ogembo

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STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice, Rebecca Baum, Shrutie Sharma, Jason M. Organ, Christopher Jakobs, Veit Hornung, David B. Burr, Ann Marshak-Rothstein, Katherine A. Fitzgerald, and Ellen M. Gravallese

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HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins, Damien Bertheloot and Eicke Latz

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Soluble Uric Acid Activates the NLRP3 Inflammasome, Tarcio Teodoro Braga, Maria Fernanda Forni, Matheus Correa-Costa, Rodrigo Nalio Ramos, Jose Alexandre Barbuto, Paola Branco, Angela Castoldi, Meire Ioshie Hiyane, Mariana Rodrigues Davanso, Eicke Latz, Bernardo S. Franklin, Alicia J. Kowaltowski, and Niels Olsen Saraiva Camara

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Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor, Srinjoy Chakraborti

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Implementing a Fee-for-Service Cervical Cancer Screening and Treatment Program in Cameroon: Challenges and Opportunities, Geneva A. DeGregorio, Simon Manga, Edith Kiyang, Florence Manjuh, Leslie Bradford, Preetam Cholli, Richard Wamai, Rebecca Kemunto Ogembo, Zacharie Sando, Yuxin Liu, Lisa Kennedy Sheldon, Kathleen Nulah, Thomas Welty, Edith Welty, and Javier Gordon Ogembo

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A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events, Nathaniel Erskine, Hoang Tran, Len L. Levin, Christine M. Ulbricht, Joyce D. Fingeroth, Catarina I. Kiefe, Robert J. Goldberg, and Sonal Singh

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The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans, Don B. Gammon, Takao Ishidate, Lichao Li, Weifeng Gu, Neal S. Silverman, and Craig C. Mello

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Different Journeys, Same Destination: Exploring the Role of a PYHIN Protein and Involvement of Caspase-8 in the Regulation and Activation of Inflammasomes, Sreya Ghosh

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Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma, Evelyn V. Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, and Stuart M. Levitz

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Development of a Reporter System for In Vivo Monitoring of gamma-Secretase Activity in Drosophila, Young Gi Hong, Seyun Roh, Donggi Paik, and Sangyun Jeong

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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN), Parisa Kalantari, Omid F. Harandi, Sarika Agarwal, Florentina Rus, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Daniel R. Caffrey, and Douglas T. Golenbock

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The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis, Kyung J. Kwon-Chung and Stuart M. Levitz

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The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis, Kyung J. Kwon-Chung, Stuart M. Levitz, and Arturo Casadevall

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Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension, Yeong Hann Ling, Shalini M. Krishnan, Christopher T. Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K. Kemp-Harper, Chrishan S. Samuel, Timothy D. Hewitson, Eicke Latz, Ashley Mansell, Christopher G. Sobey, and Grant R. Drummond

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Investigating the Role of PIR1 and CD200R1 in the Innate Immune Response to Viral Pathogens, Christopher R. MacKay

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Screening of TNFalpha, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study, Angelica Mera-Ramirez, Andres Castillo, Yenifer Orobio, Maria Adelaida. Gomez, and Carolina Gallego-Marin

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Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent, Sudesh Pawaria, Shrutie Sharma, Rebecca Baum, Kerstin Nundel, Patricia Busto, Ellen M. Gravallese, Katherine A. Fitzgerald, and Ann Marshak-Rothstein

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Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice, Elizabeth M. Perez, Joslyn Foley, Timelia Tison, Rute Silva, and Javier Gordon Ogembo

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Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum, Jacob E. Schrum

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Interleukin-17: Why the Worms Squirm, Noah J. Silverstein and Jun R. Huh

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Drosophilosophical: Re-thinking Adaptive Immunity in the Fly, Cara C. West and Neal S. Silverman

Publications from 2016

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Incidence of Dengue Virus Infection in Adults and Children in a Prospective Longitudinal Cohort in the Philippines, Maria Theresa Alera, Anon Srikiatkhachorn, John Mark Velasco, Ilya A. Tac-An, Catherine B. Lago, Hannah Clapham, Stefan Fernandez, Jens W. Levy, Butsaya Thaisomboonsuk, Chonticha Klungthong, Louis R. Macareo, Ananda Nisalak, Laura L. Hermann, Daisy Villa, and In-Kyu Yoon

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Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4, Warrison A. Andrade, Sarika Agarwal, Shunyan Mo, Scott A. Shaffer, Joseph P. Dillard, Tobias Schmidt, Veit Hornung, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Douglas T. Golenbock

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Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production, Warrison A. Andrade, Arnaud Firon, Tobias Schmidt, Veit Hornung, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, Patrick Trieu-Cuot, Douglas T. Golenbock, and Pierre-Alexandre Kaminski

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Immunology. An RNA twist to T(H)17 cells, Maninjay K. Atianand and Katherine A. Fitzgerald

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A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation, Maninjay K. Atianand, Emiliano P. Ricci, Ankit Bhatta, Stefan A. Schattgen, Jason D. McGowan, Juliana Blin, Joerg E. Braun, Pallavi Gandhi, Melissa J. Moore, Daniel R. Caffrey, and Katherine A. Fitzgerald

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Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity, Franck J. Barrat, Keith B. Elkon, and Katherine A. Fitzgerald

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Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice, Rebecca Baum, Kerstin Nundel, Sudesh Pawaria, Shrutie Sharma, Patricia Busto, Katherine A. Fitzgerald, Ellen M. Gravallese, and Ann Marshak-Rothstein

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A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, and Samuel M. Behar

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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons, Elizabeth C. Carroll, Katherine A. Fitzgerald, and Ed C. Lavelle

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Phase-Variable Heptose I Glycan Extensions Modulate Efficacy of 2C7 Vaccine Antibody Directed against Neisseria gonorrhoeae Lipooligosaccharide, Srinjoy Chakraborti, Lisa A. Lewis, Andrew D. Cox, Frank St. Michael, Jianjun Li, Peter A. Rice, and Sanjay Ram

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Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease, John R. Chancellor, Sriranjani P. Padmanabhan, Thomas C. Greenough, Richard Sacra, Richard T. Ellison III, Lawrence C. Madoff, Rebecca Droms, David Hinkle, George K. Asdourian, Robert W. Finberg, Ute Stroher, Timothy M. Uyeki, and Olga M. Cerón

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Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans, Hilary K. Cheesman, Rhonda Feinbaum, Jose Thekkiniath, Robert H. Dowen, Annie L. Conery, and Read Pukkila-Worley

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The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring, Gloria B. Choi, Yeong S. Yim, Helen Wong, Sangdoo Kim, Hyunju Kim, Sangwon V. Kim, Charles A. Hoeffer, Dan R. Littman, and Jun R. Huh

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Long-term activation of the innate immune system in atherosclerosis, Anette Christ, Siroon Bekkering, Eicke Latz, and Niels P. Riksen

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Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection, Hannah Clapham and Sharone Green

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Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001, Matthew R. Costa, Justin Pollara, Regina Whitney Edwards, Michael S. Seaman, Miroslaw K. Gorny, David C. Montefiori, Hua-Xin Liao, Guido Ferrari, Shan Lu, and Shixia Wang

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Prevalence, Predictors, and Same Day Treatment of Positive VIA Enhanced by Digital Cervicography and Histopathology Results in a Cervical Cancer Prevention Program in Cameroon, Geneva A. DeGregorio, Leslie Bradford, Rebecca Kemunto Ogembo, Yuxin Liu, and Javier Gordon Ogembo

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Performance of the G4 Xpert(R) MTB/RIF assay for the detection of Mycobacterium tuberculosis and rifampin resistance: a retrospective case-control study of analytical and clinical samples from high- and low-tuberculosis prevalence settings, Nila J. Dharan, Robert Blakemore, Alexander Sloutsky, Devinder Kaur, Richard C. Alexander, Minoo Ghajar, Kimberlee A. Musser, Vincent E. Escuyer, Marie-Claire Rowlinson, Susanne Crowe, Rafael Laniado-Laborin, Eloise Valli, Pamela Nabeta, Pamela Johnson, and David Alland

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Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression, Roland Elling, Jennie Chan, and Katherine A. Fitzgerald

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Complete Genome Sequences of Zika Virus Strains Isolated from the Blood of Patients in Thailand in 2014 and the Philippines in 2012, D. W. Ellison and Anon Srikiatkhachorn

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The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi, Jonatan Ersching, Jose Ronnie Vasconcelos, Camila P. Ferreira, Braulia C. Caetano, Alexandre Vieira Machado, Oscar Bruna-Romero, Monique A. Baron, Ludmila R.P. Ferreira, Edecio Cunha-Neto, Kenneth L. Rock, Ricardo T. Gazzinelli, and Mauricio Martins Rodrigues

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Genomic insights into the Ixodes scapularis tick vector of Lyme disease, Monika Gulia-Nuss,; Daniel R. Caffrey; Neal S. Silverman; Adam R. Wespiser; and Catherine A. Hill

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The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection, Kelly N. Hallstrom and Beth A. McCormick

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Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria, Isabella C. Hirako, Marco Antonio Ataide, Lucas Faustino, Patricia A. Assis, Elizabeth W. Sorensen, Hisashi Ueta, Natalia M. Araujo, Gustavo B. Menezes, Andrew D. Luster, and Ricardo T. Gazzinelli

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The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury, Bo Hu, Katherine A. Fitzgerald, and Richard A. Flavell

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Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation, Hai Hu, Joyce D. Fingeroth, and Gerburg M. Wulf

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Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via Stimulator of Interferon Genes., Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Abhishek Satishchandran, Patrick Lowe, Karen Kodys, Donna Catalano, Charles D. Calenda, Evelyn A. Kurt-Jones, Kate A. Fitzgerald, and Gyongyi Szabo

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A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina L. Prachanronarong, L. Safak Yilmaz, Daniel R. Caffrey, Konstantin B. Zeldovich, Celia A. Schiffer, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, and Daniel N. Bolon

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Control of the innate immune response by the mevalonate pathway, Zhaozhao Jiang, Celia E. Foster, Annie S. Li, Xiaoman Zhang, Ruth M. Gavin, Sorcha D. Forde, Gail Germain, Susan B. Carpenter, Neal S. Silverman, Ellen M. Gravallese, Katherine A. Fitzgerald, Douglas T. Golenbock, and Donghai Wang

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A Model to Explain How the Bacille Calmette Guerin (BCG) Vaccine Drives Interleukin-12 Production in Neonates, Chido Loveness Kathivu and Daniel H. Libraty

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Highlights from the 6th International Meeting on Emerging Diseases and Surveillance (IMED 2016) Vienna, Austria from Nov 3 to 7, 2016, Britta Lassmann and Lawrence C. Madoff

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Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila, Bo Liu, Yonggang Zheng, Feng Yin, Jianzhong Yu, Neal S. Silverman, and Duojia Pan

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DNA immunization as a technology platform for monoclonal antibody induction, Shuying Liu, Shixia Wang, and Shan Lu

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ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation, Amanda J. Monahan, Anni Kleino, and Neal S. Silverman

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Apontic regulates somatic stem cell numbers in Drosophila testes, Amanda J. Monahan and Michelle Starz-Gaiano

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Dental Calculus Stimulates Interleukin-1beta Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes, Jorge Luis Montenegro Raudales, Atsutoshi Yoshimura, Ziauddin Sm, Takashi Kaneko, Yukio Ozaki, Takashi Ukai, Toshihiro Miyazaki, Eicke Latz, and Yoshitaka Hara

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State-of-the-art monitoring in treatment of dengue shock syndrome: a case series, Steven L. Moulton, Jane Mulligan, Anon Srikiatkhachorn, Siripen Kalanarooj, Greg Z. Grudic, Sharone Green, Robert V. Gibbons, Gary W. Muniz, Carmen Hinojosa-Laborde, Alan L. Rothman, Stephen J. Thomas, and Victor A. Convertino

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A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling, Clíona Ní Cheallaigh, Jinhee Lee, Kim West, Nuria Martinez, Hardy Kornfeld, Douglas T. Golenbock, and Ed C. Lavelle

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Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation, Kendi Okuda, Mei Tong, Brian Dempsey, Kathryn J. Moore, Ricardo T. Gazzinelli, and Neal S. Silverman

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How Would Children Register Their Own Births? Insights from a Survey of Students Regarding Birth Registration Knowledge and Policy Suggestions in Kenya, Matthew Pelowski, Richard G. Wamai, Joseph Wangombe, Hellen Nyakundi, Geofrey O. Oduwo, Benjamin K. Ngugi, and Javier Gordon Ogembo

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Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI, Susanne Pfeiler, Eicke Latz, and Bernd Engelmann

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Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans, Read Pukkila-Worley

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CpG Improves Influenza Vaccine Efficacy in Young Adult but Not Aged Mice, Alejandor Ramirez, Mary Dawn T. Co, and Anuja Mathew

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Inflammasome Complexes: Emerging Mechanisms and Effector Functions, Vijay A.K. Rathinam and Katherine A. Fitzgerald

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The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation, Dmitry Ratner, M. Pontus A. Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, and Egil Lien

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Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS, Line S. Reinert, Katarina Lopusna, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vaegter, Jens R. Nyengaard, Katherine A. Fitzgerald, and Soren R. Paludan

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Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission, Henrik Salje and Anon Srikiatkhachorn

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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics, George Savidis, William M. McDougall, Paul Meraner, Jill Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, and Abraham L. Brass

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The IFITMs Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, and Abraham L. Brass

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Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2, Stefan A. Schattgen, Guangping Gao, Evelyn A. Kurt-Jones, and Katherine A. Fitzgerald

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A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines, John Suschak, Shixia Wang, Katherine A. Fitzgerald, and Shan Lu

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Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition, Michelle D. Tate, James D.H. Ong, Jennifer K. Dowling, Julie L. McAuley, Avril B. Robertson, Eicke Latz, Grant R. Drummond, Matthew A. Cooper, Paul J. Hertzog, and Ashley Mansell

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Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells, Elizabeth Townsley, G. O'Connor, C. Cosgrove, Marcia Woda, Mary Dawn T. Co, S. J. Thomas, Siripen Kalayanarooj, In-Kyu Yoon, Ananda Nisalak, Anon Srikiatkhachorn, Sharone Green, H. A. F. Stephens, Emma Gostick, David A. Price, M. Carrington, Galit Alter, D. W. McVicar, Alan L. Rothman, and Anuja Mathew

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Properdin Levels in Individuals with Chemotherapy-Induced Neutropenia, Artsiom Tsyrkunou, Sarika Agarwal, Bibek Koirala, Robert W. Finberg, Rajneesh Nath, Bruce A. Barton, Stuart M. Levitz, Jennifer P. Wang, and Sanjay Ram

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A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, and Douglas T. Golenbock

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Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans, Rajendra Upadhya, Woei C. Lam, Brian Maybruck, Charles A. Specht, Stuart M. Levitz, and Jennifer K. Lodge

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S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3, Fuan Wang, Zhaozhao Jiang, Katherine A. Fitzgerald, and Brian D. Lichty

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Dynamics of dengue virus-specific B cells in the response to dengue virus-1 infections using flow cytometry with labeled virions, Marcia Woda, Heather Friberg, Jeffrey R. Currier, Anon Srikiatkhachorn, Louis R. Macareo, Sharone Green, Richard G. Jarman, Alan L. Rothman, and Anuja Mathew

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Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae, Sandy M. Wong, Jutamas Shaughnessy, Sanjay Ram, and Brian J. Akerley

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Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming, Sebastian Zimmer and Eicke Latz

Publications from 2015

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Cutting Edge: AIM2 and Endosomal TLRs Differentially Regulate Arthritis and Autoantibody Production in DNase II-Deficient Mice, Rebecca Baum, Shrutie Sharma, Susan Carpenter, Quan-Zhen Li, Patricia Busto, Katherine A. Fitzgerald, Ann Marshak-Rothstein, and Ellen M. Gravallese

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Sequential dengue virus infections detected in active and passive surveillance programs in Thailand, 1994-2010, Piraya Bhoomiboonchoo, Ananda Nisalak, Natkamol Chansatiporn, In-Kyu Yoon, Siripen Kalayanarooj, Mathuros Thipayamongkolgul, Timothy Endy, Alan L. Rothman, Sharone Green, Anon Srikiatkhachorn, Darunee Buddhari, Mammen P. Mammen, and Robert V. Gibbons

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Perspective: The RNA exosome, cytokine gene regulation and links to autoimmunity, Juliana Blin and Katherine A. Fitzgerald

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Electronic control device prongs: a growing cause of bloodborne pathogen exposure?, Susan L. Bradbury, Martin A. Reznek, Susan Sullivan, Philip Adamo, Deborah Ann Mack, and Richard T. Ellison III

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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage, Denise N. Bronner, Basel H. Abuaita, Xiaoyun Chen, Katherine A. Fitzgerald, Gabriel Nunez, Yongqun He, Xiao-Ming Yin, and Mary X. O'Riordan D

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Cutting Edge: A Natural Antisense Transcript, AS-IL1alpha, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1alpha, Jennie Chan, Maninjay K. Atianand, Zhaozhao Jiang, Susan B. Carpenter, Daniel Aiello, Roland Elling, Katherine A. Fitzgerald, and Daniel R. Caffrey

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Regulatory T cells resist virus infection-induced apoptosis, Jenny Wun-Yue Che, Anke R.M. Kraft, Liisa K. Selin, and Raymond M. Welsh

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Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease, Sameer S. Chopra, Ignaty Leshchiner, Hatice Duzkale, Heather McLaughlin, Monica Giovanni, Chengsheng Zhang, Nathan Stitziel, Joyce D. Fingeroth, Robin M. Joyce, Matthew Lebo, Heidi Rehm, Dana Vuzman, Richard Maas, Shamil R. Sunyaev, Michael Murray, and Christopher A. Cassa

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Epidemiology of Infant Dengue Cases Illuminates Serotype-Specificity in the Interaction between Immunity and Disease, and Changes in Transmission Dynamics, Hannah Clapham, Derek A. Cummings, Ananda Nisalak, Siripen Kalayanarooj, Butsaya Thaisomboonsuk, Chonticha Klungthong, Stefan Fernandez, Anon Srikiatkhachorn, Louis R. Macareo, Justin Lessler, Julia Reiser, and In-Kyu Yoon

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Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin, Yolanda Corbett, Silvia Parapini, Sarah D'Alessandro, Diletta Scaccabarozzi, Bruno C. Rocha, Timothy J. Egan, Aneesa Omar, Laura Galastri, Katherine A. Fitzgerald, Douglas T. Golenbock, Donatella Taramelli, and Nicoletta Basilico

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A Prospective Controlled Trial of an Electronic Hand Hygiene Reminder System, Richard T. Ellison III, Constance Barysauskas, Elke A. Rundensteiner, Di Wang, and Bruce A. Barton

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Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors, David Ermert, Jutamas Shaughnessy, Thorsten Joeris, Jakub Kaplan, Catherine J. Pang, Evelyn A. Kurt-Jones, Peter A. Rice, Sanjay Ram, and Anna M. Blom

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GBPs take AIM at Francisella, Katherine A. Fitzgerald and Vijay A. K. Rathinam

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Family Outbreaks of Nontyphoidal Salmonellosis following a Meal of Guinea Pigs, John B. Fournier, Kimberly Knox, Maureen Harris, and Michael Newstein

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Viral infection of engrafted human islets leads to diabetes, Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, and Jennifer P. Wang

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Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection, Laura L. Gibson, Constance Barysauskas, Margaret M. McManus, Sheryl Dooley, Daniele Lilleri, Donna Fisher, Tumul Srivastava, Don J. Diamond, and Katherine Ruiz De Luzuriaga

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Vaccination and heterologous immunity: educating the immune system, Anna Gil, Laurie L. Kenney, Rabinarayan Mishra, Levi B. Watkin, Nuray Aslan, and Liisa K. Selin