This collection showcases the journal articles and other publications authored by researchers in the Imbalzano Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2014

Link

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin, L. Damiano, K. M. Stewart, Nathalie Cohet, J. K. Mouw, J. N. Lakins, J. Debnath, D. Reisman, Jeffrey A. Nickerson, Anthony N. Imbalzano, and V. M. Weaver (Oncogene)

PDF

The PPARgamma locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner, Scott E. LeBlanc, Qiong Wu, A. Rasim Barutcu, Hengyi Xiao, Yasuyuki Ohkawa, and Anthony N. Imbalzano (PloS one)

Submissions from 2013

PDF

The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state, J. Manuel Hernandez-Hernandez, Chandrashekara Mallappa, Brian T. Nasipak, Steffi Oesterreich, and Anthony N. Imbalzano (Nucleic acids research)

PDF

Prmt7 is dispensable in tissue culture models for adipogenic differentiation, Yu-Jie Hu, Said Sif, and Anthony N. Imbalzano (F1000Research)

PDF

BRG1, a SWI/SNF chromatin remodeling enzyme ATPase, is required for maintenance of nuclear shape and integrity, Anthony N. Imbalzano, Karen M. Imbalzano, and Jeffrey A. Nickerson (Communicative and integrative biology)

PDF

Nuclear Shape Changes Are Induced by Knockdown of the SWI/SNF ATPase BRG1 and Are Independent of Cytoskeletal Connections, Karen M. Imbalzano, Nathalie Cohet, Qiong Wu, Jean M. Underwood, Anthony N. Imbalzano, and Jeffrey A. Nickerson (PloS one)

Link

Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice, Giovane G. Tortelote, Jose Manuel Hernandez, Alexandre J. C. Quaresma, Jeffrey A. Nickerson, Anthony N. Imbalzano, and Jaime A. Rivera-Perez (Developmental biology)

Submissions from 2012

Link

Chd2 interacts with H3.3 to determine myogenic cell fate, Akihito Harada, Seiji Okada, Daijiro Konno, Jun Odawara, Tomohiko Yoshimi, Saori Yoshimura, Hiromi Kumamaru, Hirokazu Saiwai, Toshiaki Tsubota, Hitoshi Kurumizaka, Koichi Akashi, Taro Tachibana, Anthony N. Imbalzano, and Yasuyuki Ohkawa (The EMBO journal)

Link

Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase delta Catalytic Subunit Gene, POLD1, Vrajesh Karkhanis, Li Wang, Sookil Tae, Yu-Jie Hu, Anthony N. Imbalzano, and Said Sif (The Journal of biological chemistry)

Link

Protein Arginine Methyltransferase 5 (Prmt5) Promotes Gene Expression of Peroxisome Proliferator-Activated Receptor gamma2 (PPARgamma2) and Its Target Genes during Adipogenesis, Scott E. LeBlanc, Silvana Konda, Qiong Wu, Yu-Jie Hu, Christine M. Oslowski, Said Sif, and Anthony N. Imbalzano (Molecular endocrinology (Baltimore, Md.))

Link

An Improved Restriction Enzyme Accessibility Assay for Analyzing Changes in Chromatin Structure in Samples of Limited Cell Number, Yasuyuki Ohkawa, Chandrashekara Mallappa, Caroline S. Dacwag Vallaster, and Anthony N. Imbalzano (Methods in molecular biology (Clifton, N.J.))

Link

Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays, Yasuyuki Ohkawa, Chandrashekara Mallappa, Caroline S. Dacwag Vallaster, and Anthony N. Imbalzano (Methods in molecular biology (Clifton, N.J.))

Submissions from 2011

Link

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos, Ok Hyun Cho, Jaime A. Rivera-Perez, and Anthony N. Imbalzano (Journal of visualized experiments : JoVE)

Link

Versatility of PRMT5-induced methylation in growth control and development, Vrajesh Karkhanis, Yu-Jie Hu, Robert A. Baiocchi, Anthony N. Imbalzano, and Said Sif (Trends in biochemical sciences)

PDF

The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4, Chandrashekara Mallappa, Yu-Jie Hu, Priscilla Shamulailatpam, Sookil Tae, Said Sif, and Anthony N. Imbalzano (Nucleic acids research)

Link

Dicer is required for the formation of white but not brown adipose tissue, Rajini R. Mudhasani, Vishwajeet Puri, Kathleen Hoover, Michael P. Czech, Anthony N. Imbalzano, and Stephen N. Jones (Journal of cellular physiology)

Link

Chromatin accessibility and transcription factor binding at the PPARgamma2 promoter during adipogenesis is protein kinase a-dependent, Hengyi Xiao, Scott E. LeBlanc, Qiong Wu, Silvana Konda, Nunciada Salma, Concetta G. A. Marfella, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Journal of cellular physiology)

Submissions from 2010

Link

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells, Nathalie Cohet, Kathleen M. Stewart, Rajini R. Mudhasani, Ananthi J. Asirvatham, Chandrashekara Mallappa, Karen M. Imbalzano, Valerie M. Weaver, Anthony N. Imbalzano, and Jeffrey A. Nickerson (Journal of cellular physiology)

Link

Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function, Chandrashekara Mallappa, Brian T. Nasipak, Letitiah Etheridge, Elliot J. Androphy, Stephen N. Jones, Charles G. Sagerstrom, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Molecular and cellular biology)

Link

An essential role for Dicer in adipocyte differentiation, Rajini R. Mudhasani, Anthony N. Imbalzano, and Stephen N. Jones (Journal of cellular biochemistry)

Submissions from 2009

Link

Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation, Caroline S. Dacwag, Mark T. Bedford, Said Sif, and Anthony N. Imbalzano (Molecular and cellular biology)

PDF

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture, Karen M. Imbalzano, Iva Tatarkova, Anthony N. Imbalzano, and Jeffrey A. Nickerson (Cancer cell international)

Link

Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression, Jitesh Pratap, Karen M. Imbalzano, Jean. M. Underwood, Nathalie Cohet, Karthiga Devi Gokul, Jacqueline Akech, Andre J. Van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Jeffrey A. Nickerson, Jane B. Lian, and Gary S. Stein (Cancer research)

Submissions from 2008

Link

Phenotypic transcription factors epigenetically mediate cell growth control, Syed A. Ali, Sayyed K. Zaidi, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, A. Rauf Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein (Proceedings of the National Academy of Sciences of the United States of America)

Link

A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype, Concetta G. A. Marfella, Nils Henninger, Scott E. LeBlanc, Namrata Krishnan, David S. Garlick, Lawrence B. Holzman, and Anthony N. Imbalzano (Kidney and blood pressure research)

PDF

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells, Rajini R. Mudhasani, Zhiqing Zhu, Gyorgy Hutvagner, Christine M. Eischen, Stephen Lyle, Lisa L. Hall, Jeanne B. Lawrence, Anthony N. Imbalzano, and Stephen N. Jones (The Journal of cell biology)

PDF

Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte stress 1 gene promoter, Samir Ounzain, Caroline S. Dacwag, Nilesh J. Samani, Anthony N. Imbalzano, and Nelson W. Chong (BMC molecular biology)

Submissions from 2007

PDF

The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling, Caroline S. Dacwag, Yasuyuki Ohkawa, Sharmistha Pal, Said Sif, and Anthony N. Imbalzano (Molecular and cellular biology)

Link

The Chd family of chromatin remodelers, Concetta G. A. Marfella and Anthony N. Imbalzano (Mutation research)

Link

Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis, Yasuyuki Ohkawa, Saori Yoshimura, Chiduru Higashi, Concetta G. A. Marfella, Caroline S. Dacwag, Taro Tachibana, and Anthony N. Imbalzano (The Journal of biological chemistry)

Submissions from 2006

Link

The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes, Ivana L. de la Serna, Yasuyuki Ohkawa, Chiduru Higashi, Chaitali Dutta, Jules Osias, Naveen Kommajosyula, Taro Tachibana, and Anthony N. Imbalzano (The Journal of biological chemistry)

Link

Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers, Ivana L. de la Serna, Yasuyuki Ohkawa, and Anthony N. Imbalzano (Nature reviews. Genetics)

PDF

Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis, Cynthia J. Guidi, Rajini R. Mudhasani, Kathleen Hoover, Andrew Koff, Irwin Leav, Anthony N. Imbalzano, and Stephen N. Jones (Cancer research)

Link

HMGN1 is dispensable for myogenesis and adipogenesis, David A. Hill and Anthony N. Imbalzano (Gene)

Link

Mutation of the SNF2 family member Chd2 affects mouse development and survival, Concetta G. A. Marfella, Ohkawa Yasuyuki, Andrew H. Coles, David S. Garlick, Stephen N. Jones, and Anthony N. Imbalzano (Journal of cellular physiology)

Link

Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1, Yasuyuki Ohkawa, Concetta G. A. Marfella, and Anthony N. Imbalzano (The EMBO journal)

Link

Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo, Nunciada Salma, Hengyi Xiao, and Anthony N. Imbalzano (Journal of molecular endocrinology)

Link

The ultrastructure of MCF-10A acini, Jean. M. Underwood, Karen M. Imbalzano, Valerie M. Weaver, Andrew H. Fischer, Anthony N. Imbalzano, and Jeffrey A. Nickerson (Journal of cellular physiology)

Submissions from 2005

PDF

MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex, Ivana L. de la Serna, Yasuyuki Ohkawa, Charlotte A. Berkes, Donald A. Bergstrom, Caroline S. Dacwag, Stephen J. Tapscott, and Anthony N. Imbalzano (Molecular and cellular biology)

Link

Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling, David A. Hill, Craig L. Peterson, and Anthony N. Imbalzano (The Journal of biological chemistry)

Link

Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability, Anthony N. Imbalzano and Stephen N. Jones (Cancer cell)

Submissions from 2004

Link

Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes, Diem N. Doan, Timothy M. Veal, Zhijiang Yan, Weidong Wang, Stephen N. Jones, and Anthony N. Imbalzano (Oncogene)

Link

Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor, Cynthia J. Guidi, Timothy M. Veal, Stephen N. Jones, and Anthony N. Imbalzano (The Journal of biological chemistry)

PDF

Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme, David A. Hill, Simion I. Chiosea, Saha Jamaluddin, Kanaklata Roy, Andrew H. Fischer, Douglas D. Boyd, Jeffrey A. Nickerson, and Anthony N. Imbalzano (Journal of cell science)

Link

Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor, Nunciada Salma, Hengyi Xiao, Elisabetta Mueller, and Anthony N. Imbalzano (Molecular and cellular biology)

Submissions from 2002

Link

The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture, Kanaklata Roy, Ivana L. de la Serna, and Anthony N. Imbalzano (The Journal of biological chemistry)

Submissions from 2001

Link

Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation, Ivana L. de la Serna, Kerri A. Carlson, and Anthony N. Imbalzano (Nature genetics)

Link

MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes, Ivana L. de la Serna, Kanaklata Roy, Kerri A. Carlson, and Anthony N. Imbalzano (The Journal of biological chemistry)

PDF

Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Cynthia J. Guidi, Arthur T. Sands, Brian P. Zambrowicz, Tod K. Turner, Delia A. Demers, William Webster, Thomas W. Smith, Anthony N. Imbalzano, and Stephen N. Jones (Molecular and cellular biology)

Submissions from 2000

PDF

Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene, Ivana L. de la Serna, Kerri A. Carlson, David A. Hill, Cynthia J. Guidi, Ryan O. Stephenson, Said Sif, Robert E. Kingston, and Anthony N. Imbalzano (Molecular and cellular biology)

Link

Human SWI/SNF nucleosome remodeling activity is partially inhibited by linker histone H1, David A. Hill and Anthony N. Imbalzano (Biochemistry)