Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: examining evidence for the schizo-obsessive subtype
Department of Psychiatry; Shriver Center; Center for Health Policy and Research
Medical Subject Headings
Adult; Cognition Disorders; Craniofacial Abnormalities; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; *Phenotype; Psychotic Disorders; Schizophrenia; *Schizophrenic Psychology
Psychiatry | Psychiatry and Psychology
Obsessive-compulsive symptoms or obsessive-compulsive disorder (OCD) is estimated to occur in up to 30% of patients with schizophrenia. Whether this subgroup of patients is cognitively, affectively, or physiologically distinct remains unclear. 204 schizophrenia patients, 15 who also met criteria for a diagnosis of OCD, and 147 healthy controls were examined on several intermediate phenotypes. The patient groups did not differ from each other except that the co-morbid group exhibited an elevated rate of eye-tracking dysfunction. Results suggest that OCD-co-morbid patients did not comprise a distinct subgroup based on the measures studied here, although systematic assessment of larger cohorts is warranted.
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Citation: Schizophr Res. 2012 Sep;140(1-3):83-6. doi: 10.1016/j.schres.2012.06.033. Link to article on publisher's site
Docherty, Anna R.; Coleman, Michael J.; Tu, Xiawei; Deutsch, Curtis K.; Mendell, Nancy R.; and Levy, Deborah L., "Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: examining evidence for the schizo-obsessive subtype" (2012). Center for Health Policy and Research (CHPR) Publications. 99.