Title
Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence
UMMS Affiliation
Department of Psychiatry; Shriver Center; Center for Health Policy and Research
Date
10-2012
Document Type
Article
Medical Subject Headings
Molecular Epidemiology; Neuropsychiatry
Disciplines
Medical Genetics | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology
Abstract
The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.
Rights and Permissions
Citation: Behav Brain Sci. 2012 Oct;35(5):363-4. doi: 10.1017/S0140525X12001392. Link to article on publisher's site