Center for Health Policy and Research (CHPR) Publications

Title

Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence

UMMS Affiliation

Department of Psychiatry; Shriver Center; Center for Health Policy and Research

Date

10-2012

Document Type

Article

Medical Subject Headings

Molecular Epidemiology; Neuropsychiatry

Disciplines

Medical Genetics | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology

Abstract

The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.

Comments

Citation: Behav Brain Sci. 2012 Oct;35(5):363-4. doi: 10.1017/S0140525X12001392. Link to article on publisher's site

Related Resources

Link to Article in PubMed