Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence
Department of Psychiatry; Shriver Center; Center for Health Policy and Research
Medical Subject Headings
Molecular Epidemiology; Neuropsychiatry
Medical Genetics | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology
The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.
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Citation: Behav Brain Sci. 2012 Oct;35(5):363-4. doi: 10.1017/S0140525X12001392. Link to article on publisher's site