Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear
UMass Chan Affiliations
Intellectual and Developmental Disabilities Research CenterCenter for Health Policy and Research
Department of Psychiatry
Shriver Center
Document Type
Journal ArticlePublication Date
2011-01-04Keywords
AnimalsBody Patterning
Chick Embryo
Cycloheximide
Ear, Inner
Gene Expression Regulation, Developmental
In Situ Hybridization
Mice
Microspheres
Signal Transduction
T-Box Domain Proteins
Tretinoin
beta-Galactosidase
Cell and Developmental Biology
Developmental Biology
Metadata
Show full item recordAbstract
Vertebrate hearing and balance are based in complex asymmetries of inner ear structure. Here, we identify retinoic acid (RA) as an extrinsic signal that acts directly on the ear rudiment to affect its compartmentalization along the anterior-posterior axis. A rostrocaudal wave of RA activity, generated by tissues surrounding the nascent ear, induces distinct responses from anterior and posterior halves of the inner ear rudiment. Prolonged response to RA by posterior otic tissue correlates with Tbx1 transcription and formation of mostly nonsensory inner ear structures. By contrast, anterior otic tissue displays only a brief response to RA and forms neuronal elements and most sensory structures of the inner ear.Source
Bok J, Raft S, Kong KA, Koo SK, Dräger UC, Wu DK. Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):161-6. doi: 10.1073/pnas.1010547108. Epub 2010 Dec 20. PubMed PMID: 21173260; PubMed Central PMCID: PMC3017143. Link to article on publisher's siteDOI
10.1073/pnas.1010547108Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34595Related Resources
Link to Article in PubMedRights
Publisher PDF posted as allowed by the publisher's author rights policy at http://www.pnas.org/site/aboutpnas/authorfaq.xhtml.
ae974a485f413a2113503eed53cd6c53
10.1073/pnas.1010547108