Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence
Department of Psychiatry; Shriver Center; Center for Health Policy and Research
Medical Subject Headings
Adult; African Americans; Cocaine-Related Disorders; Cues; Feasibility Studies; Genotype; Humans; Logistic Models; Male; *Polymorphism, Single Nucleotide; Receptors, GABA-A; Receptors, Opioid, mu; Synaptic Transmission
Genetics and Genomics | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology | Substance Abuse and Addiction
BACKGROUND: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving.
METHODS: Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive.
RESULTS: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03).
CONCLUSIONS: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.
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Citation: Am J Addict. 2012 Sep-Oct;21(5):411-5. doi: 10.1111/j.1521-0391.2012.00253.x. Link to article on publisher's site