Translational Science

 

The Translational Science program is an academic program of the /">Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. A major goal of biological research is to acquire insight and tools to solve problems in medicine. The new program in Translational Science was developed to address this goal and train graduate students to bring the power of cutting-edge biological tools to bear upon clinical problems. Program faculty members possess broad expertise in both basic and clinical research. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Translational Science students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2017

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Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease, Shashi Bala, Timea Csak, Karen Kodys, Donna Catalano, Aditya Ambade, Istvan Furi, Patrick Lowe, Yeonhee Cho, Arvin Iracheta-Vellve, and Gyongyi Szabo

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Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Shashi Bala, Timea Csak, Karen Kodys, and Gyongyi Szabo

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Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice, Patrick Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V. Ward, and Gyongyi Szabo

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Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development and craniofacial morphogenesis., Zachary J. Milstone, Grace Lawson, and Chinmay M. Trivedi

Publications from 2016

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Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice, Terence N. Bukong, Arvin Iracheta-Vellve, Benedek Gyongyosi, Aditya Ambade, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease, Terence N. Bukong, Arvin Iracheta-Vellve, Banishree Saha, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via Stimulator of Interferon Genes., Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Abhishek Satishchandran, Patrick Lowe, Karen Kodys, Donna Catalano, Charles D. Calenda, Evelyn A. Kurt-Jones, Kate A. Fitzgerald, and Gyongyi Szabo

Publications from 2015

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MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Karen Kodys, Donna Catalano, Arvin Iracheta-Vellve, and Gyongyi Szabo

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Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Abhishek Satishchandran, Benedek Gyongyosi, Banishree Saha, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Histone deacetylase 3 coordinates deacetylase-independent epigenetic silencing of TGFβ1 to orchestrate second heart field development, Sara L. Lewandowski, Harish P. Janardhan, and Chinmay M. Trivedi

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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Banishree Saha, Abhishek Satishchandran, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis, Gyongyi Szabo and Arvin Iracheta-Vellve

Publications from 2014

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Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells, Stefan Bohr, Suraj J. Patel, Radovan Vasko, Keyue Shen, Arvin Iracheta-Vellve, Jungwoo Lee, Shyam Sundhar Bale, Nilay Chakraborty, Michael Brines, Anthony Cerami, Francois Berthiaume, and Martin L. Yarmush

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Histone Deacetylase 3 Modulates Tbx5 Activity to Regulate Early Cardiogenesis, Sara L. Lewandowski, Harish P. Janardhan, Kevin M. Smee, Marcos Bachman, Zheng Sun, Mitchell A. Lazar, and Chinmay M. Trivedi

Publications from 2013

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo