GSBS Student Publications

Title

Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles

UMMS Affiliation

Graduate School of Biomedical Sciences; W. Harry Feinstone Department of Molecular Microbiology and Immunology; Department of Pathology

Date

7-11-2000

Document Type

Article

Medical Subject Headings

Animals; Antibodies, Viral; Drug Administration Routes; Exanthema; Hemagglutinins, Viral; Immunization, Secondary; Macaca mulatta; Measles; Measles Vaccine; Neutralization Tests; Pneumonia; Skin; *Vaccination; Vaccines, Attenuated; Vaccines, DNA; Viral Fusion Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Measles remains a principal cause of worldwide mortality, in part because young infants cannot be immunized effectively. Development of new vaccines has been hindered by previous experience with a formalin-inactivated vaccine that predisposed to a severe form of disease (atypical measles). Here we have developed and tested potential DNA vaccines for immunogenicity, efficacy and safety in a rhesus macaque model of measles. DNA protected from challenge with wild-type measles virus. Protection correlated with levels of neutralizing antibody and not with cytotoxic T lymphocyte activity. There was no evidence in any group, including those receiving hemagglutinin-encoding DNA alone, of 'priming' for atypical measles.

Rights and Permissions

Citation: Nat Med. 2000 Jul;6(7):776-81. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Nature medicine

PubMed ID

10888926