Tec family kinases in T lymphocyte development and function
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Pathology
Medical Subject Headings
Animals; Antigens, CD28; Enzyme Activation; Humans; Mice; Models, Immunological; Molecular Structure; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes
Life Sciences | Medicine and Health Sciences
The Tec family tyrosine kinases are now recognized as important mediators of antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec, are expressed in T cells and activated in response to T cell receptor (TCR) engagement. Although initial studies demonstrated a role for these proteins in TCR-mediated activation of phospholipase C-gamma, recent data indicate that Tec family kinases also regulate actin cytoskeletal reorganization and cellular adhesion following TCR stimulation. In addition, Tec family kinases are activated downstream of G protein-coupled chemokine receptors, where they play parallel roles in the regulation of Rho GTPases, cell polarization, adhesion, and migration. In all these systems, however, Tec family kinases are not essential signaling components, but instead function to modulate or amplify signaling pathways. Although they quantitatively reduce proximal signaling, mutations that eliminate Tec family kinases in T cells nonetheless qualitatively alter T cell development and differentiation.
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Citation: Annu Rev Immunol. 2005;23:549-600. Link to article on publisher's site
Annual review of immunology
Berg, Leslie J.; Finkelstein, Lisa D.; Lucas, Julie Ann; and Schwartzberg, Pamela L., "Tec family kinases in T lymphocyte development and function" (2005). GSBS Student Publications. 96.