GSBS Student Publications

Title

BLyS and B cell homeostasis

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology; Department of Physiology

Date

8-26-2006

Document Type

Article

Medical Subject Headings

Alternative Splicing; Animals; Apoptosis; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocyte Subsets; Cell Survival; Homeostasis; Humans; Immunoglobulin Class Switching; Lymphoma, B-Cell; Mice; Mice, Inbred A; Models, Immunological; Neoplasm Proteins; Protein Kinases; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transfection; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.

Rights and Permissions

Citation: Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22. Link to article on publisher's site

DOI of Published Version

10.1016/j.smim.2006.06.001

Related Resources

Link to Article in PubMed

Journal Title

Seminars in immunology

PubMed ID

16931037