BLyS and B cell homeostasis
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology; Department of Physiology
Medical Subject Headings
Alternative Splicing; Animals; Apoptosis; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocyte Subsets; Cell Survival; Homeostasis; Humans; Immunoglobulin Class Switching; Lymphoma, B-Cell; Mice; Mice, Inbred A; Models, Immunological; Neoplasm Proteins; Protein Kinases; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transfection; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13
Life Sciences | Medicine and Health Sciences
Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
Rights and Permissions
Citation: Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22. Link to article on publisher's site
Seminars in immunology
Woodland, Robert T.; Schmidt, Madelyn R.; and Thompson, Craig B., "BLyS and B cell homeostasis" (2006). GSBS Student Publications. 944.