Homeostatic proliferation of B cells
Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology; Department of Physiology
Medical Subject Headings
Animals; B-Lymphocytes; *Homeostasis; Humans; Immunologic Memory; *Lymphocyte Activation; Mice
Life Sciences | Medicine and Health Sciences
Naive B cells introduced into a lymphopenic host undergo antigen-independent proliferation which is inhibited in a cell dose dependent manner by feedback from mature B cells. Homeostatic proliferation is a generalized lymphocyte property with B cells sharing many of the inductive and regulatory characteristics established for naive and memory CD4+ and CD8+ T cells and NK cells. In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory.
Rights and Permissions
Citation: Semin Immunol. 2005 Jun;17(3):209-17. Link to article on publisher's site
Seminars in immunology
Woodland, Robert T. and Schmidt, Madelyn R., "Homeostatic proliferation of B cells" (2005). GSBS Student Publications. 941.