GSBS Student Publications


Homeostatic proliferation of B cells

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology; Department of Physiology



Document Type


Medical Subject Headings

Animals; B-Lymphocytes; *Homeostasis; Humans; Immunologic Memory; *Lymphocyte Activation; Mice


Life Sciences | Medicine and Health Sciences


Naive B cells introduced into a lymphopenic host undergo antigen-independent proliferation which is inhibited in a cell dose dependent manner by feedback from mature B cells. Homeostatic proliferation is a generalized lymphocyte property with B cells sharing many of the inductive and regulatory characteristics established for naive and memory CD4+ and CD8+ T cells and NK cells. In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory.

Rights and Permissions

Citation: Semin Immunol. 2005 Jun;17(3):209-17. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal Title

Seminars in immunology

PubMed ID