GSBS Student Publications

Title

Molecular events that regulate alphabeta versus gammadelta T cell lineage commitment: old suspects, new players and different game plans

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Date

2-13-2007

Document Type

Article

Medical Subject Headings

Animals; Cell Lineage; *Lymphopoiesis; Mice; Multipotent Stem Cells; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Notch; T-Lymphocytes; Thymus Gland

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The divergence of alphabeta and gammadelta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the precise timing of lineage commitment and some clarification on the extent of the involvement of Notch and T-cell receptor signaling in this process. Combined with new insights into the differential regulation of molecular pathways active in alphabeta and gammadelta precursors, these data have led to the generation of a revised model of lineage commitment.

Rights and Permissions

Citation: Curr Opin Immunol. 2007 Apr;19(2):169-75. Epub 2007 Feb 8. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title

Current opinion in immunology

PubMed ID

17291740