An architectural perspective of vitamin D responsiveness
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Active Transport, Cell Nucleus; Animals; Cell Nucleus; Gene Expression Regulation; Humans; Receptors, Calcitriol; Signal Transduction; Vitamin D
Life Sciences | Medicine and Health Sciences
Vitamin D serves as a principal modulator of skeletal gene transcription, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiological responsiveness requires combinatorial control where coregulatory proteins determine the specificity of biological responsiveness to physiological cues. It is becoming increasingly evident that the regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.
Rights and Permissions
Citation: Arch Biochem Biophys. 2007 Apr 15;460(2):293-9. Epub 2007 Jan 8. Link to article on publisher's site