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Authors
Montecino, Martin A.Stein, Gary S.
Cruzat, Fernando
Marcellini, Sylvain
Stein, Janet L.
Lian, Jane B.
Van Wijnen, Andre J.
Arriagada, Gloria
Document Type
Journal ArticlePublication Date
2007-02-10Keywords
Active Transport, Cell Nucleus; Animals; Cell Nucleus; Gene Expression Regulation; Humans; Receptors, Calcitriol; Signal Transduction; Vitamin DLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Vitamin D serves as a principal modulator of skeletal gene transcription, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiological responsiveness requires combinatorial control where coregulatory proteins determine the specificity of biological responsiveness to physiological cues. It is becoming increasingly evident that the regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.Source
Arch Biochem Biophys. 2007 Apr 15;460(2):293-9. Epub 2007 Jan 8. Link to article on publisher's siteDOI
10.1016/j.abb.2006.12.015Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34221PubMed ID
17288986Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.abb.2006.12.015