New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
Graduate School of Biomedical Sciences; Gaa; Program in Immunology and Virology; Department of Pathology
Medical Subject Headings
1-Phosphatidylinositol 3-Kinase; Animals; Apoptosis; Cell Differentiation; Enzyme Activation; Humans; Isoenzymes; Lymphocytes; Mice; Phospholipase C gamma; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Type C Phospholipases; src Homology Domains
Life Sciences | Medicine and Health Sciences
The Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.
Rights and Permissions
Citation: Curr Opin Immunol. 2002 Jun;14(3):331-40.
Current opinion in immunology
Miller, Andrew Todd and Berg, Leslie J., "New insights into the regulation and functions of Tec family tyrosine kinases in the immune system" (2002). GSBS Student Publications. 866.