GSBS Student Publications

Title

New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

UMMS Affiliation

Graduate School of Biomedical Sciences; Gaa; Program in Immunology and Virology; Department of Pathology

Date

4-26-2002

Document Type

Article

Medical Subject Headings

1-Phosphatidylinositol 3-Kinase; Animals; Apoptosis; Cell Differentiation; Enzyme Activation; Humans; Isoenzymes; Lymphocytes; Mice; Phospholipase C gamma; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Type C Phospholipases; src Homology Domains

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.

Rights and Permissions

Citation: Curr Opin Immunol. 2002 Jun;14(3):331-40.

Related Resources

Link to article in PubMed

Journal Title

Current opinion in immunology

PubMed ID

11973131