Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
Graduate School of Biomedical Sciences; Department of Pathology
Medical Subject Headings
Animals; Antigens, CD4; Autoantigens; Cell Line; Cell Lineage; Cell Proliferation; Embryonic Development; Gene Expression Profiling; Gene Expression Regulation; Gene Rearrangement, T-Lymphocyte; High Mobility Group Proteins; Humans; *Lymphopoiesis; Mice; Mice, Transgenic; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Signal Transduction; T Cell Transcription Factor 1; T-Lymphocyte Subsets; Wnt Proteins
Life Sciences | Medicine and Health Sciences
alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
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Citation: Science. 2007 Jan 12;315(5809):230-3. Link to article on publisher's site
Science (New York, N.Y.)
Melichar, Heather J.; Narayan, Kavitha; Der, Sandy D.; Hiraoka, Yoshiki; Gardiol, Noemie; Jeannet, Gregoire; Held, Werner; Chambers, Cynthia A.; and Kang, Joonsoo, "Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13" (2007). GSBS Student Publications. 849.