GSBS Student Publications

Title

Transient decreases in human T cell proliferative responses following vaccinia immunization

UMMS Affiliation

Graduate School of Biomedical Sciences; Center for Infectious Disease and Vaccine Research

Date

7-20-2000

Document Type

Article

Medical Subject Headings

Antibodies; Antigen-Presenting Cells; Antigens, CD28; Antigens, CD3; Antigens, Viral; Humans; Immunization; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Recombinant Proteins; T-Lymphocytes; Vaccinia virus

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

To further study the immunosuppression associated with virus infections, we analyzed the proliferative responses of serial PBMC samples obtained following vaccinia virus immunization. In four of five volunteers, responses to PHA, anti-CD3, vaccinia virus, and recall antigens were markedly decreased at at least one time point between days 5 and 29 after vaccination. Responses to PHA were restored by the addition of IL-2 or irradiated autologous healthy PBMC in the two volunteers tested, suggesting that the proliferation defect is attributable to accessory cell dysfunction. In one donor, immobilized anti-CD3 failed to induce proliferation, but addition of immobilized anti-CD28 partially restored proliferation. These results indicate that vaccinia virus infection can transiently suppress proliferative responses of PBMC, in part by causing accessory cell dysfunction. Our findings extend the list of viral infections associated with systemic immunologic effects and demonstrate that suppression of proliferation can occur with localized virus infections.

Rights and Permissions

Citation: Clin Immunol. 2000 Aug;96(2):100-7. Link to article on publisher's site

DOI of Published Version

10.1006/clim.2000.4887

Related Resources

Link to article in PubMed

Journal Title

Clinical immunology (Orlando, Fla.)

PubMed ID

10900157