Title
The Chd family of chromatin remodelers
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology
Date
3-14-2007
Document Type
Article
Medical Subject Headings
Adenosine Triphosphate; Animals; Chromatin; Chromatin Assembly and Disassembly; DNA; DNA-Binding Proteins; Drosophila melanogaster; Humans; Models, Genetic; Multigene Family; *Mutation; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins; Transcription, Genetic
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease.
Rights and Permissions
Citation: Mutat Res. 2007 May 1;618(1-2):30-40. Epub 2007 Jan 21. Link to article on publisher's site