GSBS Student Publications

Title

Common principles in protein folding and antigen presentation

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pharmacology

Date

7-1-1991

Document Type

Article

Medical Subject Headings

Amino Acid Sequence; Antigens; Consensus Sequence; Epitopes; Molecular Sequence Data; Protein Conformation; Proteins; T-Lymphocytes

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The regular recurrence of hydrophobic amino acid residues along a peptide sequence determines the formation of a longitudinal hydrophobic strip when the peptide forms an alpha-helix. An understanding of the ways this may affect both folding of nascent proteins and antigen presentation should facilitate vaccine and therapeutics design.

Rights and Permissions

Citation: Trends Biotechnol. 1991 Jul;9(7):238-42.

Related Resources

Link to article in PubMed

Journal Title

Trends in biotechnology

PubMed ID

1370048