Common principles in protein folding and antigen presentation
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Pharmacology
Medical Subject Headings
Amino Acid Sequence; Antigens; Consensus Sequence; Epitopes; Molecular Sequence Data; Protein Conformation; Proteins; T-Lymphocytes
Life Sciences | Medicine and Health Sciences
The regular recurrence of hydrophobic amino acid residues along a peptide sequence determines the formation of a longitudinal hydrophobic strip when the peptide forms an alpha-helix. An understanding of the ways this may affect both folding of nascent proteins and antigen presentation should facilitate vaccine and therapeutics design.
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Citation: Trends Biotechnol. 1991 Jul;9(7):238-42.
Trends in biotechnology
Lu, Shan; Reyes, Victor E.; Torgerson, Rochelle R.; Lew, Robert A.; and Humphreys, Robert E., "Common principles in protein folding and antigen presentation" (1991). GSBS Student Publications. 788.