Title

Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Gene Function and Expression

Date

2-14-2006

Document Type

Article

Medical Subject Headings

*Apoptosis; Autoimmunity; Diabetes Mellitus; Endoplasmic Reticulum; Humans; Insulin-Secreting Cells

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and type 2 diabetes. Recent observations indicate that ER stress signaling participates in maintaining the ER homeostasis of pancreatic beta-cells. Either a high level of ER stress or defective ER stress signaling in beta-cells may cause an imbalance in ER homeostasis and lead to beta-cell apoptosis and autoimmune response. In addition, it has been suggested that ER stress attributes to insulin resistance in patients with type 2 diabetes. It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance.

Rights and Permissions

Citation: Curr Mol Med. 2006 Feb;6(1):71-7.

Related Resources

Link to article in PubMed