GSBS Student Publications


Evolution of the CD8 T-cell repertoire during infections

UMMS Affiliation

Graduate School of Biomedical Sciences; The Department of Pathology and Program in Immunology and Virology



Document Type


Medical Subject Headings

Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Flow Cytometry; Herpesvirus 4, Human; Interferon Type II; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Antigen, T-Cell, alpha-beta; Spleen; T-Lymphocyte Subsets; Virus Latency


Life Sciences | Medicine and Health Sciences


CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.

Rights and Permissions

Citation: Microbes Infect. 2000 Jul;2(9):1025-39.

Related Resources

Link to article in PubMed

Journal Title

Microbes and infection / Institut Pasteur

PubMed ID